Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

(2016) Thi Hoang Duong Nguyen et al.   NATURE

Molecular architecture of the human U4/U6.U5 tri-snRNP

(2016) D. E. Agafonov et al.   SCIENCE

The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

(2016) R. Wan et al.   SCIENCE

Structure of a yeast activated spliceosome at 3.5 A resolution

(2016) C. Yan et al.   SCIENCE

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

(2016) Samar Alsafadi et al.   Nature Communications

113Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p

(2015) Anne-Marie M. van Roon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation

(2015) Eva Absmeier et al.   GENES & DEVELOPMENT

The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome

(2015) Zbigniew Warkocki et al.   GENES & DEVELOPMENT

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

(2015) Thi Hoang Duong Nguyen et al.   NATURE

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

(2015) Ashwin Chari et al.   NATURE METHODS

Structural basis of pre-mRNA splicing

(2015) Jing Hang et al.   SCIENCE

Structure of a yeast spliceosome at 3.6-angstrom resolution

(2015) Chuangye Yan et al.   SCIENCE

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

(2015) Rachel B. Darman et al.   Cell Reports

Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes

(2015) Cornelius Schneider et al.   PLoS Genetics

A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein

(2015) Eva Absmeier et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex

(2014) Piotr Wysoczański et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence for a group II intron–like catalytic triplex in the spliceosome

(2014) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome

(2014) A. M. Wlodaver et al.   RNA

A Weak Spliceosome-Binding Domain of Yju2 Functions in the First Step and Bypasses Prp16 in the Second Step of Splicing

(2013) Ting-Wei Chiang et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystal structure of Prp8 reveals active site cavity of the spliceosome

(2013) Wojciech P. Galej et al.   NATURE

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

(2013) G. Buchwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

(2013) Thi Hoang Duong Nguyen et al.   STRUCTURE

Visualizing Group II Intron Catalysis through the Stages of Splicing

(2012) Marco Marcia et al.   CELL

Structure and assembly of the SF3a splicing factor complex of U2 snRNP

(2012) Pei-Chun Lin et al.   EMBO JOURNAL

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

The Interaction of Prp2 with a Defined Region of the Intron Is Required for the First Splicing Reaction

(2012) H.-L. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

The spliceosome as a target of novel antitumour drugs

(2012) Sophie Bonnal et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of a group II intron in the pre-catalytic state

(2012) Russell T Chan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS

(2012) T. Ohrt et al.   RNA

CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly

(2012) Anna-Lena Steckelberg et al.   Cell Reports

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

(2011) Akira Yokoi et al.   FEBS Journal

Semiquantitative Proteomic Analysis of the Human Spliceosome via a Novel Two-Dimensional Gel Electrophoresis Method

(2011) D. E. Agafonov et al.   MOLECULAR AND CELLULAR BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An Unusual Hydrophobic Core Confers Extreme Flexibility to HEAT Repeat Proteins

(2010) Christian Kappel et al.   BIOPHYSICAL JOURNAL

Nuclear export complexes in the frame

(2010) Atlanta G Cook et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Prp43p contains a processive helicase structural architecture with a specific regulatory domain

(2010) Hélène Walbott et al.   EMBO JOURNAL

Splicing Factor Cwc22 Is Required for the Function of Prp2 and for the Spliceosome To Escape from a Futile Pathway

(2010) T.-C. Yeh et al.   MOLECULAR AND CELLULAR BIOLOGY

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

(2010) R. M. Lardelli et al.   RNA

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

(2010) S. Bessonov et al.   RNA

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

(2009) Patrizia Fabrizio et al.   MOLECULAR CELL

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A structural analysis of the group II intron active site and implications for the spliceosome

(2009) K. S. Keating et al.   RNA

Crystal Structure of the Pml1p Subunit of the Yeast Precursor mRNA Retention and Splicing Complex

(2008) Simon Trowitzsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the yeast Pml1 splicing factor and its integration into the RES complex

(2008) Mark A. Brooks et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of a Self-Spliced Group II Intron

(2008) N. Toor et al.   SCIENCE