Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling

(2016) Yuyani Xiong et al.   Aging-US

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity

(2014) Yi Yu et al.   Cardiovascular Diabetology

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

(2014) Charles D. Mills et al.   Journal of Innate Immunity

Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems

(2013) Mireille Ouimet   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil

(2013) Chunyun Liu et al.   PLoS One

Transcriptional regulation of macrophage arginase 1 expression and its role in atherosclerosis

(2013) Benoit Pourcet et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability

(2013) Yuyan Xiong et al.   Journal of the American Heart Association

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation

(2013) Zhihong Yang et al.   Frontiers in Immunology

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

(2012) Gautham Yepuri et al.   AGING CELL

Protein Tyrosine Phosphatase SHP2 Mediates Chronic Insulin-Induced Endothelial Inflammation

(2012) Hemant Giri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice

(2012) Woosung Shin et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

(2012) Jan Van den Bossche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Translational evidence that impaired autophagy contributes to arterial ageing

(2012) Thomas J. LaRocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Arginase Deficiency With New Phenotype and a Novel Mutation: Contemporary Summary

(2012) Jane Pui Ki Tsang et al.   PEDIATRIC NEUROLOGY

Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice

(2012) Boris L. Vaisman et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

(2012) Xiu‐Fen Ming et al.   Journal of the American Heart Association

Immunohistochemical study of arginase 1 and 2 in various tissues of rats

(2011) Sungyoung Choi et al.   ACTA HISTOCHEMICA

Autophagy in Atherosclerosis

(2011) Dorien M. Schrijvers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arginase I Attenuates Inflammatory Cytokine Secretion Induced by Lipopolysaccharide in Vascular Smooth Muscle Cells

(2011) Xu-ping Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

(2011) Anna E. Stanhewicz et al.   JOURNAL OF APPLIED PHYSIOLOGY

To Give or Not to Give? Lessons from the Arginine Paradox

(2011) Francesco Saverio Dioguardi   Journal of Nutrigenetics and Nutrigenomics

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

(2011) Angana G. Rajapakse et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

New Role for L-Arginine in Regulation of Inducible Nitric-Oxide-Synthase-Derived Superoxide Anion Production in Raw 264.7 Macrophages

(2011) Michaela Pekarova et al.   TheScientificWorldJOURNAL

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling

(2010) Sungwoo Ryoo et al.   ATHEROSCLEROSIS

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Xanthine Oxidoreductase Promotes the Inflammatory State of Mononuclear Phagocytes through Effects on Chemokine Expression, Peroxisome Proliferator-activated Receptor-γ Sumoylation, and HIF-1α

(2010) Sophie Gibbings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 Mitogen-Activated Protein Kinase (MAPK) Increases Arginase Activity and Contributes to Endothelial Dysfunction in Corpora Cavernosa from Angiotensin-II-Treated Mice

(2010) Haroldo A. Toque et al.   Journal of Sexual Medicine

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Thrombin induces endothelial arginase through AP-1 activation

(2009) Weifei Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

(2009) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Paradoxical effect of l-arginine: Acceleration of endothelial cell senescence

(2009) Fortunato Scalera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia

(2009) Sowndramalingam Sankaralingam et al.   CARDIOVASCULAR RESEARCH

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis

(2009) C. Antoniades et al.   EUROPEAN HEART JOURNAL

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

(2009) Jae Hyung Kim et al.   JOURNAL OF APPLIED PHYSIOLOGY

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Interferon-γ priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages

(2008) Miriam V. Liscovsky et al.   IMMUNOLOGY

Arginase and vascular aging

(2008) Lakshmi Santhanam et al.   JOURNAL OF APPLIED PHYSIOLOGY

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY

Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis

(2008) Ingrid Müller et al.   PLoS Neglected Tropical Diseases

Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

(2007) Maritza J. Romero et al.   CIRCULATION RESEARCH