Approaches for the rapid identification of drug metabolites in early clinical studies

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC–ESI-QTOFMS-based metabolomics

(2010) Fei Li et al.   BIOCHEMICAL PHARMACOLOGY

Metabolites in Safety Testing: “MIST” for the Clinical Pharmacologist

(2010) C B Frederick et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Use of the Entero-Test, a Novel Approach for the Noninvasive Capture of Biliary Metabolites in Dogs

(2010) W. J. Guiney et al.   DRUG METABOLISM AND DISPOSITION

Operation of a 500 MHz high temperature superconducting NMR: Towards an NMR spectrometer operating beyond 1 GHz

(2010) Y. Yanagisawa et al.   JOURNAL OF MAGNETIC RESONANCE

Use of an Atmospheric Solids Analysis Probe (ASAP) for High Throughput Screening of Biological Fluids: Preliminary Applications on Urine and Bile

(2010) Marian Twohig et al.   JOURNAL OF PROTEOME RESEARCH

Targeted projection NMR spectroscopy for unambiguous metabolic profiling of complex mixtures

(2010) Clément Pontoizeau et al.   MAGNETIC RESONANCE IN CHEMISTRY

Chemistry: Breaking the billion-hertz barrier

(2010) Ananyo Bhattacharya   NATURE

Sites of metabolic substitution: investigating metabolite structures utilising ion mobility and molecular modelling

(2010) Gordon J. Dear et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen

(2010) E. Neirinckx et al.   RESEARCH IN VETERINARY SCIENCE

Utility of multivariate analysis in support ofin vitrometabolite identification studies: retrospective analysis using the antidepressant drug nefazodone

(2010) R. P. Schneider et al.   XENOBIOTICA

Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis

(2010) Angus NR Nedderman et al.   Bioanalysis

Ultrasound-enhanced enzymatic hydrolysis of conjugated female steroids as pretreatment for their analysis by LC–MS/MS in urine

(2009) B. Álvarez-Sánchez et al.   ANALYST

Hydrolysis of 3,4-methylenedioxymethamphetamine (MDMA) metabolite conjugates in human, squirrel monkey, and rat plasma

(2009) Melanie Mueller et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Rapid LC-MS Drug Metabolite Profiling Using Microsomal Enzyme Bioreactors in a Parallel Processing Format

(2009) Besnik Bajrami et al.   ANALYTICAL CHEMISTRY

Direct Quantitative Bioanalysis of Drugs in Dried Blood Spot Samples Using a Thin-Layer Chromatography Mass Spectrometer Interface

(2009) Paul Abu-Rabie et al.   ANALYTICAL CHEMISTRY

An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data

(2009) Peijuan Zhu et al.   ANALYTICAL CHEMISTRY

Dried Blood Spots as a Sample Collection Technique for the Determination of Pharmacokinetics in Clinical Studies: Considerations for the Validation of a Quantitative Bioanalytical Method

(2009) Neil Spooner et al.   ANALYTICAL CHEMISTRY

Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations

(2009) Mingshe Zhu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Metabolites in safety testing: metabolite identification strategies in discovery and development

(2009) Angus N. R. Nedderman   BIOPHARMACEUTICS & DRUG DISPOSITION

Human radiolabeled mass balance studies: objectives, utilities and limitations

(2009) Natalia Penner et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450

(2009) Jianjun Chen et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

(2009) Laurent Leclercq et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Interpretation and Considerations on the Safety Evaluation of Human Drug Metabolites

(2009) Aisar H. Atrakchi   CHEMICAL RESEARCH IN TOXICOLOGY

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

(2009) Don Walker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A microscale protein NMR sample screening pipeline

(2009) Paolo Rossi et al.   JOURNAL OF BIOMOLECULAR NMR

NMR Quantitation of Natural Products at the Nanomole Scale

(2009) Doralyn S. Dalisay et al.   JOURNAL OF NATURAL PRODUCTS

Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: Ion mobility mass spectrometry and modeling

(2009) Jonathan P. Williams et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Quantitative-qualitative data acquisition using a benchtop orbitrap mass spectrometer

(2009) Kevin P. Bateman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A microfluidic chip for electrochemical conversions in drug metabolism studies

(2009) M. Odijk et al.   LAB ON A CHIP

Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters

(2009) Russell J. Mortishire-Smith et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer

(2009) R. W. Adams et al.   SCIENCE

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development

(2008) Filip Cuyckens et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Unique/Major Human Metabolites: Why, How, and When to Test for Safety in Animals

(2008) Debra Luffer-Atlas   DRUG METABOLISM REVIEWS

The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies

(2008) Bente Gammelgaard et al.   Expert Opinion on Drug Metabolism & Toxicology

Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies

(2008) Gregory S Walker et al.   Expert Opinion on Drug Metabolism & Toxicology

Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

(2008) Graham Lappin et al.   Expert Opinion on Drug Metabolism & Toxicology

Optimized liquid chromatography–mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance

(2008) Gaetan Glauser et al.   JOURNAL OF CHROMATOGRAPHY A

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies

(2008) Matt Barfield et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Automated Modular Preparative HPLC-MS Purification Laboratory with Enhanced Efficiency

(2008) Oliver Guth et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

(2008) Bo Ma et al.   LAB ON A CHIP

Parahydrogen induced polarization of barbituric acid derivatives:1H hyperpolarization studies

(2008) Meike Roth et al.   MAGNETIC RESONANCE IN CHEMISTRY

Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies

(2008) Philip R. Tiller et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection

(2008) Haiying Zhang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Ionisation in the absence of high voltage using supercritical fluid chromatography: a possible route to increased signal

(2008) Mohini A. Thite et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration

(2008) Filip Cuyckens et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Analysis of human urine metabolites using SPE and NMR spectroscopy

(2008) WeiJin Yang et al.   Science in China. Series B, Chemistry

An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection

(2007) Qian Ruan et al.   JOURNAL OF MASS SPECTROMETRY