- Home
- Publications
- Publication Search
- Publication Details
Title
New Developments in Genetic rat models of Parkinson's Disease
Authors
Keywords
-
Journal
MOVEMENT DISORDERS
Volume 33, Issue 5, Pages 717-729
Publisher
Wiley
Online
2018-02-08
DOI
10.1002/mds.27296
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies
- (2018) Chao Peng et al. NEUROBIOLOGY OF DISEASE
- Toxic effects of human and rodent variants of alpha-synucleinin vivo
- (2017) Natalie Landeck et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats
- (2017) Ezia Guatteo et al. EXPERIMENTAL NEUROLOGY
- Animal models of α-synucleinopathy for Parkinson disease drug development
- (2017) James B. Koprich et al. NATURE REVIEWS NEUROSCIENCE
- α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
- (2017) Hisham Abdelmotilib et al. NEUROBIOLOGY OF DISEASE
- Emotional memory impairments induced by AAV-mediated overexpression of human α-synuclein in dopaminergic neurons of the ventral tegmental area
- (2016) A. Alvarsson et al. BEHAVIOURAL BRAIN RESEARCH
- Ade novocompound targeting α-synuclein improves deficits in models of Parkinson’s disease
- (2016) Wolfgang Wrasidlo et al. BRAIN
- LRRK2BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function
- (2016) Max Sloan et al. HUMAN MOLECULAR GENETICS
- How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?
- (2016) Laura A. Volpicelli-Daley et al. JOURNAL OF NEUROCHEMISTRY
- -Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals
- (2016) J. Xu et al. JOURNAL OF NEUROSCIENCE
- First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
- (2016) Dale B. Schenk et al. MOVEMENT DISORDERS
- Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease
- (2016) Zacharias Kohl et al. NEUROBIOLOGY OF DISEASE
- Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons
- (2016) Zhenyi Liu et al. PLoS One
- Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease
- (2016) Mohamed-Bilal Fares et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deciphering the Molecular Signals of PINK1/Parkin Mitophagy
- (2016) Thanh N. Nguyen et al. TRENDS IN CELL BIOLOGY
- Defining neurodegeneration on Guam by targeted genomic sequencing
- (2015) John C. Steele et al. ANNALS OF NEUROLOGY
- Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease
- (2015) Aurelija Jucaite et al. BRAIN
- Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons
- (2015) D. Caudal et al. EXPERIMENTAL NEUROLOGY
- Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
- (2015) João P. L. Daher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evidence for early and progressive ultrasonic vocalization and oromotor deficits in aPINK1gene knockout rat model of Parkinson's disease
- (2015) Laura M. Grant et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease
- (2015) Qing He et al. MOLECULAR NEUROBIOLOGY
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors
- (2015) Anke Van der Perren et al. NEUROBIOLOGY OF AGING
- Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats
- (2015) Jang-Won Lee et al. NEUROBIOLOGY OF AGING
- FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease
- (2015) Anke Van der Perren et al. NEUROBIOLOGY OF AGING
- α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)
- (2015) Guillaume Daniel et al. NEUROBIOLOGY OF DISEASE
- Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
- (2015) Katrina L. Paumier et al. NEUROBIOLOGY OF DISEASE
- Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
- (2015) Emily M. Rocha et al. NEUROBIOLOGY OF DISEASE
- Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease
- (2015) Elpida Tsika et al. NEUROBIOLOGY OF DISEASE
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- STEP61is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease
- (2015) Pradeep K. Kurup et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases
- (2015) Ronald Melki Journal of Parkinsons Disease
- TransgenicLRRK2R1441Grats–a model for Parkinson disease?
- (2015) Komal T. Shaikh et al. PeerJ
- Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
- (2015) Mathieu Bourdenx et al. Acta Neuropathologica Communications
- PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease
- (2014) Agne Kazlauskaite et al. FEBS Journal
- Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents
- (2014) Andrew B. West et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Early Expression of Parkinson’s Disease-Related Mitochondrial Abnormalities in PINK1 Knockout Rats
- (2014) Lance M. Villeneuve et al. MOLECULAR NEUROBIOLOGY
- Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease
- (2014) Kuldip D. Dave et al. NEUROBIOLOGY OF DISEASE
- The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease
- (2014) Lorraine Iacovitti et al. PLoS One
- Abrogation of -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
- (2014) J. P. L. Daher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
- (2013) Silke Nuber et al. BRAIN
- Heat Shock Protein 70 Reduces α-Synuclein-Induced Predegenerative Neuronal Dystrophy in the α-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease
- (2013) Teresa C. Moloney et al. CNS Neuroscience & Therapeutics
- Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model
- (2013) Fabia Febbraro et al. EXPERIMENTAL NEUROLOGY
- Modeling dyskinesia in animal models of Parkinson disease
- (2013) Nicolas Morin et al. EXPERIMENTAL NEUROLOGY
- Parkin disease and the Lewy body conundrum
- (2013) Karen M. Doherty et al. MOVEMENT DISORDERS
- Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
- (2013) Fabia Febbraro et al. NEUROBIOLOGY OF DISEASE
- Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease
- (2013) Meghan R. Hennis et al. NEUROBIOLOGY OF DISEASE
- Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis
- (2013) Daniel Ness et al. PLoS One
- Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain
- (2013) Dominik F. Aschauer et al. PLoS One
- Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System
- (2013) Sara E. Gombash et al. PLoS One
- Behavioral and Neurotransmitter Abnormalities in Mice Deficient for Parkin, DJ-1 and Superoxide Dismutase
- (2013) Meghan R. Hennis et al. PLoS One
- Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs
- (2013) Marco A. S. Baptista et al. PLoS One
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- A Guide to Neurotoxic Animal Models of Parkinson's Disease
- (2013) K. Tieu Cold Spring Harbor Perspectives in Medicine
- Genetics of Parkinson's Disease
- (2013) C. Klein et al. Cold Spring Harbor Perspectives in Medicine
- Animal Models of Parkinson's Disease: Vertebrate Genetics
- (2013) Y. Lee et al. Cold Spring Harbor Perspectives in Medicine
- Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
- (2012) Meret Nora Gaugler et al. ACTA NEUROPATHOLOGICA
- Do alpha-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?
- (2012) Hanna S. Lindgren et al. EXPERIMENTAL NEUROLOGY
- Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease
- (2012) M. Decressac et al. EXPERIMENTAL NEUROLOGY
- Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment
- (2012) Jason R. Cannon et al. EXPERIMENTAL NEUROLOGY
- Animal models of Parkinson’s disease
- (2012) Fabio Blandini et al. FEBS Journal
- GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
- (2012) A. Biosa et al. HUMAN MOLECULAR GENETICS
- Temporal Expression of Mutant LRRK2 in Adult Rats Impairs Dopamine Reuptake
- (2012) Hongxia Zhou et al. International Journal of Biological Sciences
- Animal models of l-DOPA–induced dyskinesia: an update on the current options
- (2012) H. Iderberg et al. NEUROSCIENCE
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
- (2011) Grit Taschenberger et al. ACTA NEUROPATHOLOGICA
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
- (2011) Philip J. Webber et al. JOURNAL OF MOLECULAR BIOLOGY
- A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
- (2011) J. Dusonchet et al. JOURNAL OF NEUROSCIENCE
- Parkinson’s disease mouse models in translational research
- (2011) Paul M. A. Antony et al. MAMMALIAN GENOME
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Behavioral phenotyping of mouse models of Parkinson's disease
- (2010) Tonya N. Taylor et al. BEHAVIOURAL BRAIN RESEARCH
- PINK1-linked parkinsonism is associated with Lewy body pathology
- (2010) Lluís Samaranch et al. BRAIN
- Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra
- (2010) Jason R. Cannon et al. EXPERIMENTAL NEUROLOGY
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
- (2010) Noriyuki Matsuda et al. JOURNAL OF CELL BIOLOGY
- α-Synuclein Expression in Rat Substantia Nigra Suppresses Phospholipase D2 Toxicity and Nigral Neurodegeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Threonine 53 in α-synuclein is conserved in long-living non-primate animals
- (2009) Knud Larsen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
- (2009) Tohru Kitada et al. JOURNAL OF NEUROCHEMISTRY
- Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant -Synuclein
- (2009) X.-H. Lu et al. JOURNAL OF NEUROSCIENCE
- Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
- (2009) Stéphanie Baulac et al. Molecular Neurodegeneration
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
- (2009) Malú G. Tansey et al. NEUROBIOLOGY OF DISEASE
- Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
- (2009) Suzana Gispert et al. PLoS One
- Genomic investigation of α-synuclein multiplication and parkinsonism
- (2008) Owen A. Ross et al. ANNALS OF NEUROLOGY
- Value of genetic models in understanding the cause and mechanisms of Parkinson’s disease
- (2008) Darren J. Moore et al. Current Neurology and Neuroscience Reports
- Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration
- (2008) T. C. Frank-Cannon et al. JOURNAL OF NEUROSCIENCE
- Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection
- (2008) Nirit Lev et al. NEUROTOXICOLOGY
- The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration in a rat model of Parkinson disease
- (2008) O. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tropism and toxicity of adeno-associated viral vector serotypes 1, 2, 5, 6, 7, 8, and 9 in rat neurons and glia in vitro
- (2007) Douglas B. Howard et al. VIROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation