GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
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Title
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
Authors
Keywords
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Journal
HUMAN MOLECULAR GENETICS
Volume 22, Issue 6, Pages 1140-1156
Publisher
Oxford University Press (OUP)
Online
2012-12-15
DOI
10.1093/hmg/dds522
References
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Related references
Note: Only part of the references are listed.- The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation
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- GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1
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- Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons
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- Structure-Function Relationships of the G Domain, a Canonical Switch Motif
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- Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form
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- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
- (2011) Philip J. Webber et al. JOURNAL OF MOLECULAR BIOLOGY
- A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
- (2011) J. Dusonchet et al. JOURNAL OF NEUROSCIENCE
- LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
- (2011) Jean-Marc Taymans et al. PLoS One
- Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation
- (2010) Zdenek Berger et al. BIOCHEMISTRY
- Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2
- (2010) Christian Johannes Gloeckner et al. JOURNAL OF PROTEOME RESEARCH
- GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
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- The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
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- (2009) Saurabh Sen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
- (2009) L. Parisiadou et al. JOURNAL OF NEUROSCIENCE
- It takes two to tango: regulation of G proteins by dimerization
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- The Roco protein family: a functional perspective
- (2008) Ignacio Marín et al. FASEB JOURNAL
- The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
- (2008) Elisa Greggio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
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