Present and future therapies of hepatitis B: From discovery to cure
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Present and future therapies of hepatitis B: From discovery to cure
Authors
Keywords
-
Journal
HEPATOLOGY
Volume 62, Issue 6, Pages 1893-1908
Publisher
Wiley
Online
2015-08-04
DOI
10.1002/hep.28025
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Re-evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells
- (2015) Thomas Vanwolleghem et al. HEPATOLOGY
- Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na+-taurocholate cotransporting polypeptide knockout mice
- (2015) Davor Slijepcevic et al. HEPATOLOGY
- Adding pegylated interferon to entecavir for hepatitis B e antigen-positive chronic hepatitis B: A multicenter randomized trial (ARES study)
- (2015) Willem Pieter Brouwer et al. HEPATOLOGY
- Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient
- (2015) Waseem Qasim et al. JOURNAL OF HEPATOLOGY
- The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection
- (2015) Edward J. Gane et al. JOURNAL OF HEPATOLOGY
- In vitro stimulation with HBV therapeutic vaccine candidate Nasvac activates B and T cells from chronic hepatitis B patients and healthy donors
- (2015) Yadira Lobaina et al. MOLECULAR IMMUNOLOGY
- STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus
- (2014) Fang Guo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Dissecting the dendritic cell controversy in chronic hepatitis B virus infection
- (2014) Adam J. Gehring et al. Cellular & Molecular Immunology
- A Randomized, Open-Label Clinical Study of Combined Pegylated Interferon Alfa-2a (40KD) and Entecavir Treatment for Hepatitis B "e" Antigen-Positive Chronic Hepatitis B
- (2014) Q. Xie et al. CLINICAL INFECTIOUS DISEASES
- Strategies to eliminate HBV infection
- (2014) Rama Kapoor et al. Future Virology
- Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes
- (2014) Stephan Urban et al. GASTROENTEROLOGY
- Effects of Tenofovir Disoproxil Fumarate in Hepatitis B e Antigen-Positive Patients With Normal Levels of Alanine Aminotransferase and High Levels of Hepatitis B Virus DNA
- (2014) Henry L.Y. Chan et al. GASTROENTEROLOGY
- Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial—ANRS HB02 VAC-ADN
- (2014) H Fontaine et al. GUT
- Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype
- (2014) Frédéric M. Vaz et al. HEPATOLOGY
- Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies
- (2014) Saar Gill et al. IMMUNOLOGICAL REVIEWS
- Hepatitis B Reactivation in Patients With Previous Hepatitis B Virus Exposure Undergoing Rituximab-Containing Chemotherapy for Lymphoma: A Prospective Study
- (2014) Wai-Kay Seto et al. JOURNAL OF CLINICAL ONCOLOGY
- Switching from entecavir to PegIFN alfa-2a in patients with HBeAg-positive chronic hepatitis B: A randomised open-label trial (OSST trial)
- (2014) Qin Ning et al. JOURNAL OF HEPATOLOGY
- Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation
- (2014) Bertram Bengsch et al. JOURNAL OF HEPATOLOGY
- O113 COMBINATION THERAPY WITH PEGINTERFERON ALFA-2a AND A NUCLEOS(T)IDE ANALOGUE FOR HBeAg-POSITIVE CHRONIC HEPATITIS B PATIENTS: RESULTS OF A LARGE, RANDOMISED, MULTICENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
- (2014) W.-W. Su et al. JOURNAL OF HEPATOLOGY
- Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice
- (2014) Seung Kew Yoon et al. LIVER INTERNATIONAL
- AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
- (2014) Nicholas D. Weber et al. PLoS One
- Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
- (2014) Christian Königer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
- (2014) J. Lucifora et al. SCIENCE
- Safety, tolerability and immunogenicity of GS-4774, a hepatitis B virus-specific therapeutic vaccine, in healthy subjects: A randomized study
- (2014) Anuj Gaggar et al. VACCINE
- Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance
- (2014) Luis Menéndez-Arias et al. Current Opinion in Virology
- Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly
- (2013) Guoyi Wu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Entry inhibitors and their use in the treatment of HIV-1 infection
- (2013) Aiman A. Haqqani et al. ANTIVIRAL RESEARCH
- Management of Hepatitis B: Our Practice and How It Relates to the Guidelines
- (2013) Suna Yapali et al. Clinical Gastroenterology and Hepatology
- Targeting Innate Immunity: A New Step in the Development of Combination Therapy for Chronic Hepatitis B
- (2013) Fabien Zoulim et al. GASTROENTEROLOGY
- T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice
- (2013) Karin Krebs et al. GASTROENTEROLOGY
- GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees
- (2013) Robert E. Lanford et al. GASTROENTEROLOGY
- Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes
- (2013) Yi Ni et al. GASTROENTEROLOGY
- Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts
- (2013) Alexa Schieck et al. HEPATOLOGY
- Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)
- (2013) Koichi Watashi et al. HEPATOLOGY
- Toll-like receptor agonists: current status and future perspective on their utility as adjuvants in improving antic ancer vaccination strategies
- (2013) Constantin N Baxevanis et al. Immunotherapy
- Mobilizing monocytes to cross-present circulating viral antigen in chronic infection
- (2013) Adam J. Gehring et al. JOURNAL OF CLINICAL INVESTIGATION
- Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings
- (2013) Dao-Zhen Xu et al. JOURNAL OF HEPATOLOGY
- Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor
- (2013) Shirin Nkongolo et al. JOURNAL OF HEPATOLOGY
- Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide
- (2013) H. Yan et al. JOURNAL OF VIROLOGY
- Sulfamoylbenzamide Derivatives Inhibit the Assembly of Hepatitis B Virus Nucleocapsids
- (2013) M. R. Campagna et al. JOURNAL OF VIROLOGY
- Emerging Antiviral Strategies to Interfere with Influenza Virus Entry
- (2013) Evelien Vanderlinden et al. MEDICINAL RESEARCH REVIEWS
- An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases
- (2013) Jieliang Chen et al. MOLECULAR THERAPY
- RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
- (2013) G. Liang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Assembly-Directed Antivirals Differentially Bind Quasiequivalent Pockets to Modify Hepatitis B Virus Capsid Tertiary and Quaternary Structure
- (2013) Sarah P. Katen et al. STRUCTURE
- Immune Therapeutic Strategies in Chronic Hepatitis B Virus Infection: Virus or Inflammation Control?
- (2013) Antonio Bertoletti et al. PLoS Pathogens
- Combination of DNA Prime – Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model
- (2013) Anna D. Kosinska et al. PLoS Pathogens
- Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes
- (2013) Fei Liu et al. PLoS Pathogens
- The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes
- (2013) John E. Tavis et al. PLoS Pathogens
- A Practical Approach to Immunotherapy of Hepatocellular Carcinoma Using T Cells Redirected Against Hepatitis B Virus
- (2013) Sarene Koh et al. Molecular Therapy-Nucleic Acids
- Identification of Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation
- (2012) Dawei Cai et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes
- (2012) Julie Lucifora et al. ANTIVIRAL RESEARCH
- Efficacy of Entecavir With or Without Tenofovir Disoproxil Fumarate for Nucleos(t)ide-Naïve Patients With Chronic Hepatitis B
- (2012) Anna S. Lok et al. GASTROENTEROLOGY
- Preserved T-Cell Function in Children and Young Adults With Immune-Tolerant Chronic Hepatitis B
- (2012) Patrick T.F. Kennedy et al. GASTROENTEROLOGY
- IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
- (2012) Laura Belloni et al. JOURNAL OF CLINICAL INVESTIGATION
- Dissecting the divergent effects of interferon-alpha on immune cells: Time to rethink combination therapy in chronic hepatitis B?
- (2012) Robert Thimme et al. JOURNAL OF HEPATOLOGY
- Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B
- (2012) Lorenzo Micco et al. JOURNAL OF HEPATOLOGY
- Inhibition of Alpha Interferon (IFN- )-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN-
- (2012) J. Hao et al. JOURNAL OF VIROLOGY
- Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis
- (2012) H.-C. Huang et al. JOURNAL OF VIROLOGY
- Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study
- (2012) Patrick Marcellin et al. LANCET
- Host factors involved in hepatitis B virus maturation, assembly, and egress
- (2012) Reinhild Prange MEDICAL MICROBIOLOGY AND IMMUNOLOGY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- PD-1 Blockage Reverses Immune Dysfunction and Hepatitis B Viral Persistence in a Mouse Animal Model
- (2012) Horng-Tay Tzeng et al. PLoS One
- Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity
- (2012) J.J. Ott et al. VACCINE
- Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
- (2012) Huan Yan et al. eLife
- The main Hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication
- (2011) Gaëtan Billioud et al. ANTIVIRAL RESEARCH
- Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
- (2011) Antonio Bertoletti et al. GUT
- Reasons to consider earlier treatment of chronic HBV infections
- (2011) Fabien Zoulim et al. GUT
- EASL Clinical Practice Guidelines: Management of hepatitis C virus infection
- (2011) JOURNAL OF HEPATOLOGY
- Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
- (2011) Julie Lucifora et al. JOURNAL OF HEPATOLOGY
- Roles of the Envelope Proteins in the Amplification of Covalently Closed Circular DNA and Completion of Synthesis of the Plus-Strand DNA in Hepatitis B Virus
- (2011) T. B. Lentz et al. JOURNAL OF VIROLOGY
- Hepatitis B prevention, diagnosis, treatment and care: a review
- (2011) E. J. Aspinall et al. OCCUPATIONAL MEDICINE-OXFORD
- The host–pathogen interaction during HBV infection: immunological controversies
- (2010) Antonio Bertoletti et al. ANTIVIRAL THERAPY
- Hepatitis B Immunology for Clinicians
- (2010) Kyong-Mi Chang Clinics in Liver Disease
- The natural history of chronic hepatitis B virus infection
- (2010) Brian J. McMahon HEPATOLOGY
- Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks
- (2010) Pamela A. Norton et al. HEPATOLOGY
- Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B
- (2010) Watcharasak Chotiyaputta et al. JOURNAL OF HEPATOLOGY
- APOBEC1 and APOBEC3 Cytidine Deaminases as Restriction Factors for Hepadnaviral Genomes in Non-Humans In Vivo
- (2010) Myrtille Renard et al. JOURNAL OF MOLECULAR BIOLOGY
- Interferons Accelerate Decay of Replication-Competent Nucleocapsids of Hepatitis B Virus
- (2010) C. Xu et al. JOURNAL OF VIROLOGY
- APOBEC3 proteins mediate the clearance of foreign DNA from human cells
- (2010) Mark D Stenglein et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer
- (2010) Ivan Hirsch et al. TRENDS IN IMMUNOLOGY
- Nucleoporin 153 Arrests the Nuclear Import of Hepatitis B Virus Capsids in the Nuclear Basket
- (2010) André Schmitz et al. PLoS Pathogens
- Chronic hepatitis B: Update 2009
- (2009) Anna S. F. Lok et al. HEPATOLOGY
- A Function Essential to Viral Entry Underlies the Hepatitis B Virus "a" Determinant
- (2009) J. Salisse et al. JOURNAL OF VIROLOGY
- Hepatitis B Virus Requires Intact Caveolin-1 Function for Productive Infection in HepaRG Cells
- (2009) A. Macovei et al. JOURNAL OF VIROLOGY
- Management and prevention of drug resistance in chronic hepatitis B
- (2009) Fabien Zoulim et al. LIVER INTERNATIONAL
- HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells
- (2009) Yongfen Xu et al. MOLECULAR IMMUNOLOGY
- Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
- (2009) L. Belloni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
- (2009) Nobuhiro Nakamoto et al. PLoS Pathogens
- T Cells Redirected Against Hepatitis B Virus Surface Proteins Eliminate Infected Hepatocytes
- (2008) Felix Bohne et al. GASTROENTEROLOGY
- Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update
- (2008) Yun-Fan Liaw et al. Hepatology International
- DNA vaccines: developing new strategies to enhance immune responses
- (2008) Shaheed A. Abdulhaqq et al. IMMUNOLOGIC RESEARCH
- Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection
- (2008) A. Ross Lopes et al. JOURNAL OF CLINICAL INVESTIGATION
- Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
- (2008) Abhishek Das et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Amount of Hepatocyte Turnover That Occurred during Resolution of Transient Hepadnavirus Infections Was Lower When Virus Replication Was Inhibited with Entecavir
- (2008) W. S. Mason et al. JOURNAL OF VIROLOGY
- Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
- (2008) Joerg Petersen et al. NATURE BIOTECHNOLOGY
- A Randomized Controlled Phase IIb Trial of Antigen-Antibody Immunogenic Complex Therapeutic Vaccine in Chronic Hepatitis B Patients
- (2008) Dao-Zhen Xu et al. PLoS One
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started