Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once

(2014) Susan E. Tsutakawa et al.   DNA REPAIR

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

(2014) Benu Brata Das et al.   NUCLEIC ACIDS RESEARCH

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

Generation of assays and antibodies to facilitate the study of human 5′-tyrosyl DNA phosphodiesterase

(2013) Graeme Thomson et al.   ANALYTICAL BIOCHEMISTRY

New Mechanistic and Functional Insights into DNA Topoisomerases

(2013) Stefanie Hartman Chen et al.   Annual Review of Biochemistry

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

Large-Scale Production and Structural and Biophysical Characterizations of the Human Hepatitis B Virus Polymerase

(2013) J. Voros et al.   JOURNAL OF VIROLOGY

Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

(2013) Y. Maede et al.   MOLECULAR CANCER THERAPEUTICS

A direct role for small non-coding RNAs in DNA damage response

(2013) Fabrizio d’Adda di Fagagna   TRENDS IN CELL BIOLOGY

Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver

(2013) Georget Y. Reaiche-Miller et al.   VIROLOGY

Tdp2: A Means to Fixing the Ends

(2013) John L. Nitiss et al.   PLoS Genetics

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Effectiveness of Hepatitis B Treatment in Clinical Practice

(2012) Steven J. Scaglione et al.   GASTROENTEROLOGY

Biochemical Characterization of Human Tyrosyl-DNA Phosphodiesterase 2 (TDP2/TTRAP)

(2012) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

(2012) Junko Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host-targeting agents for prevention and treatment of chronic hepatitis C – Perspectives and challenges

(2012) Mirjam B. Zeisel et al.   JOURNAL OF HEPATOLOGY

Long-term hepatitis B surface antigen (HBsAg) kinetics during nucleoside/nucleotide analogue therapy: Finite treatment duration unlikely

(2012) Stéphane Chevaliez et al.   JOURNAL OF HEPATOLOGY

Protein-Primed Terminal Transferase Activity of Hepatitis B Virus Polymerase

(2012) S. A. Jones et al.   JOURNAL OF VIROLOGY

In Vitro Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase

(2012) S. A. Jones et al.   JOURNAL OF VIROLOGY

Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose

(2012) Keith W. Caldecott   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2

(2012) Matthew J Schellenberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2

(2012) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

(2012) Zhihong Zeng et al.   NUCLEIC ACIDS RESEARCH

An RNA virus hijacks an incognito function of a DNA repair enzyme

(2012) R. Virgen-Slane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity

(2012) J.J. Ott et al.   VACCINE

Development of a novel assay for human tyrosyl DNA phosphodiesterase 2

(2011) Sanjay Adhikari et al.   ANALYTICAL BIOCHEMISTRY

Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1

(2011) Heidrun Interthal et al.   BIOCHEMICAL JOURNAL

Pleiotropic functions of EAPII/TTRAP/TDP2

(2011) Chunyang Li et al.   CELL CYCLE

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

(2011) Shar-yin N Huang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Oncogenic role of EAPII in lung cancer development and its activation of the MAPK–ERK pathway

(2011) C Li et al.   ONCOGENE

Genomes in Conflict: Maintaining Genome Integrity During Virus Infection

(2010) Matthew D. Weitzman et al.   Annual Review of Microbiology

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites

(2010) Dianxing Sun et al.   JOURNAL OF HEPATOLOGY

Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

(2010) Kyoko Nakamura et al.   PLoS Genetics

Generation of Covalently Closed Circular DNA of Hepatitis B Viruses via Intracellular Recycling Is Regulated in a Virus Specific Manner

(2010) Josef Köck et al.   PLoS Pathogens

Hepatitis B Virus Resistance to Nucleos(t)ide Analogues

(2009) Fabien Zoulim et al.   GASTROENTEROLOGY

Control of cccDNA function in hepatitis B virus infection

(2009) Massimo Levrero et al.   JOURNAL OF HEPATOLOGY

Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA

(2009) Edgar Hartsuiker et al.   MOLECULAR CELL

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations

(2008) S Zucchelli et al.   CELL DEATH AND DIFFERENTIATION

Hepatitis B viruses: Reverse transcription a different way

(2008) Michael Nassal   VIRUS RESEARCH

Uses and misuses of progress curve analysis in enzyme kinetics

(2008) Natalia Nikolova et al.   Open Life Sciences