Regulation of Sensing, Transportation, and Catabolism of Nitrogen Sources in Saccharomyces cerevisiae

Novel tRNA function in amino acid sensing of yeast Tor complex1

(2017) Yoshiaki Kamada   GENES TO CELLS

Mutant Potential Ubiquitination Sites in Dur3p Enhance the Urea and Ethyl Carbamate Reduction in a Model Rice Wine System

(2017) Peng Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation inSaccharomyces cerevisiae

(2017) Wenjie Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae

(2017) Kyle Mohler et al.   NUCLEIC ACIDS RESEARCH

Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells

(2016) Vitor Teixeira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Target of rapamycin signaling mediates vacuolar fragmentation

(2016) Bobbiejane Stauffer et al.   CURRENT GENETICS

General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization

(2016) Jennifer J. Tate et al.   GENETICS

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae

(2016) Seda Yerlikaya et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2

(2016) Shintaro Kira et al.   MOLECULAR BIOLOGY OF THE CELL

Steady-state and dynamic gene expression programs in Saccharomyces cerevisiae in response to variation in environmental nitrogen

(2016) Edoardo M. Airoldi et al.   MOLECULAR BIOLOGY OF THE CELL

General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization

(2016) Jennifer J. Tate et al.   GENETICS

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

(2016) Katie Powis et al.   Cell Discovery

Genome-wide mapping of nucleosome positions in Saccharomyces cerevisiae in response to different nitrogen conditions

(2016) Peng Zhang et al.   Scientific Reports

Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes

(2015) Naoko Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Post-translational modifications on yeast carbon metabolism: Regulatory mechanisms beyond transcriptional control

(2015) Farida Tripodi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

(2015) Katie Powis et al.   CELL RESEARCH

Nuclear Gln3 Import Is Regulated by Nitrogen Catabolite Repression Whereas Export Is Specifically Regulated by Glutamine

(2015) R. Rai et al.   GENETICS

ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors

(2015) Stephan R. Starick et al.   GENOME RESEARCH

CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins

(2015) Daniel Savic et al.   GENOME RESEARCH

Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation

(2015) Hongfang Qiu et al.   GENOME RESEARCH

Membrane Trafficking in the Yeast Saccharomyces cerevisiae Model

(2015) Serge Feyder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of nitrogen catabolite repression-related amino acids on the flavour of rice wine

(2015) Xinrui Zhao et al.   JOURNAL OF THE INSTITUTE OF BREWING

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2

(2015) Christl Gaubitz et al.   MOLECULAR CELL

Theoretical estimates of exposure timescales of protein binding sites on DNA regulated by nucleosome kinetics

(2015) Jyotsana J. Parmar et al.   NUCLEIC ACIDS RESEARCH

Premature termination ofGAT1transcription explains paradoxical negative correlation between nitrogen-responsive mRNA, but constitutive low-level protein production

(2015) Georis Isabelle et al.   RNA Biology

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

(2015) Marie-Pierre Péli-Gulli et al.   Cell Reports

GATA Factor Regulation in Excess Nitrogen Occurs Independently of Gtr-Ego Complex-Dependent TorC1 Activation

(2015) Jennifer J. Tate et al.   G3-Genes Genomes Genetics

An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma

(2015) Pattaya Seeree et al.   International Journal of Genomics

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

(2014) Shintaro Kira et al.   Autophagy

Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2

(2014) Yuki Usami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Glucose- and nitrogen sensing and regulatory mechanisms inSaccharomyces cerevisiae

(2014) Steven V. Rødkaer et al.   FEMS YEAST RESEARCH

Nitrogen Starvation and TorC1 Inhibition Differentially Affect Nuclear Localization of the Gln3 and Gat1 Transcription Factors Through the Rare Glutamine tRNA CUG in Saccharomyces cerevisiae

(2014) Jennifer J. Tate et al.   GENETICS

Stress Conditions Promote Yeast Gap1 Permease Ubiquitylation and Down-regulation via the Arrestin-like Bul and Aly Proteins

(2014) Myriam Crapeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative proteomic analysis of Saccharomyces cerevisiae under different nitrogen sources

(2014) Shaohui Zhao et al.   Journal of Proteomics

Substrate-Induced Ubiquitylation and Endocytosis of Yeast Amino Acid Permeases

(2014) K. Ghaddar et al.   MOLECULAR AND CELLULAR BIOLOGY

Accumulation of a Threonine Biosynthetic Intermediate Attenuates General Amino Acid Control by Accelerating Degradation of Gcn4 via Pho85 and Cdk8

(2014) Yashpal Rawal et al.   PLoS Genetics

Metabolic Engineering of the Regulators in Nitrogen Catabolite Repression To Reduce the Production of Ethyl Carbamate in a Model Rice Wine System

(2013) Xinrui Zhao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

(2013) Benjamin M. Sutter et al.   CELL

SEACing the GAP that nEGOCiates TORC1 activation

(2013) Nicolas Panchaud et al.   CELL CYCLE

Genetic Manipulation of the Fusarium fujikuroi Fusarin Gene Cluster Yields Insight into the Complex Regulation and Fusarin Biosynthetic Pathway

(2013) Eva-Maria Niehaus et al.   CHEMISTRY & BIOLOGY

Validation (in-house and collaboratory) of the quantification method for ethyl carbamate in alcoholic beverages and soy sauce by GC–MS

(2013) Zhu Huang et al.   FOOD CHEMISTRY

Disruption of the nitrogen regulatory gene AcareA in Acremonium chrysogenum leads to reduction of cephalosporin production and repression of nitrogen metabolism

(2013) Jinyang Li et al.   FUNGAL GENETICS AND BIOLOGY

Phosphorylation of a conserved Thr357 in yeast Nedd4-like ubiquitin ligase Rsp5 is involved in down-regulation of the general amino acid permease Gap1

(2013) Toshiya Sasaki et al.   GENES TO CELLS

Constitutive and Nitrogen Catabolite Repression-sensitive Production of Gat1 Isoforms

(2013) Rajendra Rai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

A simple procedure for protein ubiquitination detection in Saccharomyces cerevisiae: Gap1p as an example

(2013) Yongkun Lv et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Rts1-protein phosphatase 2A antagonizes Ptr3-mediated activation of the signaling protease Ssy5 by casein kinase I

(2013) Deike J. Omnus et al.   MOLECULAR BIOLOGY OF THE CELL

The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae

(2013) Erwin Swinnen et al.   MOLECULAR BIOLOGY OF THE CELL

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Progress in preventing the accumulation of ethyl carbamate in alcoholic beverages

(2013) Xinrui Zhao et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Nitrogen regulation involved in the accumulation of urea inSaccharomyces cerevisiae

(2013) Xinrui Zhao et al.   YEAST

Glutamate: a truly functional amino acid

(2012) John T. Brosnan et al.   AMINO ACIDS

Biosynthesis of Fusarubins Accounts for Pigmentation of Fusarium fujikuroi Perithecia

(2012) Lena Studt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?

(2012) Belém Sampaio-Marques et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

ARF1 and ARF3 Are Required for the Integrity of Recycling Endosomes and the Recycling Pathway

(2012) Yumika Kondo et al.   CELL STRUCTURE AND FUNCTION

A comparative study of structures and structural transitions of secondary transporters with the LeuT fold

(2012) Gunnar Jeschke   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae

(2012) P. O. Ljungdahl et al.   GENETICS

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

Crystal Structure of the Gtr1pGTP-Gtr2pGDPProtein Complex Reveals Large Structural Rearrangements Triggered by GTP-to-GDP Conversion

(2012) Jae-Hee Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations in the Ure2 αCap Domain Elicit Different GATA Factor Responses to Rapamycin Treatment and Nitrogen Limitation

(2012) Andre Feller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

gln3Mutations Dissociate Responses to Nitrogen Limitation (Nitrogen Catabolite Repression) and Rapamycin Inhibition of TorC1

(2012) Rajendra Rai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast

(2012) N. Valbuena et al.   JOURNAL OF CELL SCIENCE

The Amino Acid-Polyamine-Organocation Superfamily

(2012) Foon H. Wong et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Interplay between the transcription factors acting on the GATA- and GABA-responsive elements of Saccharomyces cerevisiae UGA promoters

(2012) S. B. Cardillo et al.   MICROBIOLOGY-SGM

Internal Amino Acids Promote Gap1 Permease Ubiquitylation via TORC1/Npr1/14-3-3-Dependent Control of the Bul Arrestin-Like Adaptors

(2012) A. Merhi et al.   MOLECULAR AND CELLULAR BIOLOGY

The TOR Complex 1 Is a Direct Target of Rho1 GTPase

(2012) Gonghong Yan et al.   MOLECULAR CELL

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

Amino Acid Signaling in TOR Activation

(2011) Joungmok Kim et al.   Annual Review of Biochemistry

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation

(2011) R. Gong et al.   GENES & DEVELOPMENT

Transcriptional Regulation inSaccharomyces cerevisiae: Transcription Factor Regulation and Function, Mechanisms of Initiation, and Roles of Activators and Coactivators

(2011) Steven Hahn et al.   GENETICS

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Nitrogen-responsive Regulation of GATA Protein Family Activators Gln3 and Gat1 Occurs by Two Distinct Pathways, One Inhibited by Rapamycin and the Other by Methionine Sulfoximine

(2011) Isabelle Georis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transport activity–dependent intracellular sorting of the yeast general amino acid permease

(2011) Natalie E. Cain et al.   MOLECULAR BIOLOGY OF THE CELL

A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5

(2011) Deike J. Omnus et al.   MOLECULAR BIOLOGY OF THE CELL

Constructing and decoding unconventional ubiquitin chains

(2011) Christian Behrends et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2  (eIF2 ) restricts phosphorylation of Ser51

(2011) M. Dey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

E2s: structurally economical and functionally replete

(2010) Dawn M. Wenzel et al.   BIOCHEMICAL JOURNAL

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

(2010) Bart Smets et al.   CURRENT GENETICS

Converging views of endocytosis in yeast and mammals

(2010) Elizabeth Conibear   CURRENT OPINION IN CELL BIOLOGY

Differential Regulation of Transcription Factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 Amino Acid Sensing Pathway

(2010) Sylvester Tumusiime et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Phosphatase Requirements and GATA Factor Responses to Nitrogen Catabolite Repression and Rapamycin Treatment inSaccharomyces cerevisiae

(2010) Jennifer J. Tate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast

(2010) Kirk A. Staschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Prodomain of Ssy5 Protease Controls Receptor-Activated Proteolysis of Transcription Factor Stp1

(2010) T. Pfirrmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2

(2010) R. Hatakeyama et al.   MOLECULAR AND CELLULAR BIOLOGY

α-Arrestins Aly1 and Aly2 Regulate Intracellular Trafficking in Response to Nutrient Signaling

(2010) Allyson F. O'Donnell et al.   MOLECULAR BIOLOGY OF THE CELL

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ubiquitin code of yeast permease trafficking

(2010) Elsa Lauwers et al.   TRENDS IN CELL BIOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Amino-acid-induced signalling via the SPS-sensing pathway in yeast

(2009) Per O. Ljungdahl   BIOCHEMICAL SOCIETY TRANSACTIONS

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

(2009) Vanja Nagy et al.   BIOLOGICAL CHEMISTRY

Transcriptional regulation of nonfermentable carbon utilization in budding yeast

(2009) Bernard Turcotte et al.   FEMS YEAST RESEARCH

Amino Acid Signaling in Yeast: Post-genome Duplication Divergence of the Stp1 and Stp2 Transcription Factors

(2009) Kevin Wielemans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Recognition of the Palmitoylation Substrate Vac8 by Its Palmitoyltransferase Pfa3

(2009) Marissa J. Nadolski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

(2009) Elsa Lauwers et al.   JOURNAL OF CELL BIOLOGY

The Yeast GATA Factor Gat1 Occupies a Central Position in Nitrogen Catabolite Repression-Sensitive Gene Activation

(2009) I. Georis et al.   MOLECULAR AND CELLULAR BIOLOGY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Biosynthesis of the red pigment bikaverin inFusarium fujikuroi: genes, their function and regulation

(2009) Philipp Wiemann et al.   MOLECULAR MICROBIOLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arrestin-Mediated Endocytosis of Yeast Plasma Membrane Transporters

(2009) Elina Nikko et al.   TRAFFIC

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

(2009) Taavi K. Neklesa et al.   PLoS Genetics

HowSaccharomycesResponds to Nutrients

(2008) Shadia Zaman et al.   Annual Review of Genetics

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

Ethyl carbamate in foods and beverages: a review

(2008) J. V. Weber et al.   Environmental Chemistry Letters

TOR1 and TOR2 Have Distinct Locations in Live Cells

(2008) Thomas W. Sturgill et al.   EUKARYOTIC CELL

Involvement of Nitrogen Regulation in Bacillus subtilis degU Expression

(2008) A. Yasumura et al.   JOURNAL OF BACTERIOLOGY

Tor Pathway Control of the Nitrogen-responsiveDAL5Gene Bifurcates at the Level of Gln3 and Gat1 Regulation inSaccharomyces cerevisiae

(2008) Isabelle Georis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor

(2008) Peter Poulsen et al.   MOLECULAR MEMBRANE BIOLOGY

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae

(2008) R. Puria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE