Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

(2015) Katie Powis et al.   CELL RESEARCH

The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

(2015) J. Numrich et al.   JOURNAL OF CELL SCIENCE

Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins

(2015) Y. Katoh et al.   JOURNAL OF CELL SCIENCE

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

(2014) Shintaro Kira et al.   Autophagy

Amino acid residues required for Gtr1p-Gtr2p complex formation and its interactions with the Ego1p-Ego3p complex and TORC1 components in yeast

(2014) Takeshi Sekiguchi et al.   GENES TO CELLS

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

(2014) Daniele Stracka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles for PI(3,5)P2 in nutrient sensing through TORC1

(2014) Natsuko Jin et al.   MOLECULAR BIOLOGY OF THE CELL

SEACing the GAP that nEGOCiates TORC1 activation

(2013) Nicolas Panchaud et al.   CELL CYCLE

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis

(2012) Hitoshi Nakatogawa et al.   Autophagy

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Crystal Structure of the Gtr1pGTP-Gtr2pGDPProtein Complex Reveals Large Structural Rearrangements Triggered by GTP-to-GDP Conversion

(2012) Jae-Hee Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1

(2012) Tianlong Zhang et al.   STRUCTURE

Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation

(2011) R. Gong et al.   GENES & DEVELOPMENT

Seamless Gene Tagging by Endonuclease-Driven Homologous Recombination

(2011) Anton Khmelinskii et al.   PLoS One

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

(2010) Marta H. Kubala et al.   PROTEIN SCIENCE

Amino-acid-induced signalling via the SPS-sensing pathway in yeast

(2009) Per O. Ljungdahl   BIOCHEMICAL SOCIETY TRANSACTIONS

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation

(2008) Tomoko Kawamata et al.   MOLECULAR BIOLOGY OF THE CELL

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE