The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan

(2013) Jun Liu et al.   AGING CELL

Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase

(2013) Robert L. Lester et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification of C18:1-Phytoceramide as the Candidate Lipid Mediator for Hydroxyurea Resistance in Yeast

(2013) Nabil Matmati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis

(2013) Mitsugu Shimobayashi et al.   MOLECULAR BIOLOGY OF THE CELL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast

(2012) M. Liu et al.   JOURNAL OF CELL SCIENCE

Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast

(2012) Kentaro Kajiwara et al.   MOLECULAR MICROBIOLOGY

Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics

(2012) Christian Klose et al.   PLoS One

Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism

(2012) António Rego et al.   PLoS One

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

(2012) Xinhe Huang et al.   PLoS Genetics

Ceramide triggers metacaspase-independent mitochondrial cell death in yeast

(2011) Didac Carmona-Gutierrez et al.   CELL CYCLE

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Yeast 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Orthologs Pkh1–3 Differentially Regulate Phosphorylation of Protein Kinase A (PKA) and the Protein Kinase B (PKB)/S6K Ortholog Sch9

(2011) Karin Voordeckers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramides as modulators of cellular and whole-body metabolism

(2011) Benjamin T. Bikman et al.   JOURNAL OF CLINICAL INVESTIGATION

Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells

(2011) António Daniel Barbosa et al.   MOLECULAR MICROBIOLOGY

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

(2010) Bart Smets et al.   CURRENT GENETICS

Membranes in Balance: Mechanisms of Sphingolipid Homeostasis

(2010) David K. Breslow et al.   MOLECULAR CELL

Revealing a signaling role of phytosphingosine-1-phosphate in yeast

(2010) L Ashley Cowart et al.   Molecular Systems Biology

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skn1 and Ipt1 negatively regulate autophagy inSaccharomyces cerevisiae

(2009) Karin Thevissen et al.   FEMS MICROBIOLOGY LETTERS

Stress-induced Ceramide-activated Protein Phosphatase Can Compensate for Loss of Amphiphysin-like Activity InSaccharomyces cerevisiaeand Functions to Reinitiate Endocytosis

(2009) Paula C. McCourt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ISC1-dependent Metabolic Adaptation Reveals an Indispensable Role for Mitochondria in Induction of Nuclear Genes during the Diauxic Shift inSaccharomyces cerevisiae

(2009) Hiroshi Kitagaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

(2009) Min Wei et al.   PLoS Genetics

Increased Respiration in thesch9ΔMutant Is Required for Increasing Chronological Life Span but Not Replicative Life Span

(2008) Hugo Lavoie et al.   EUKARYOTIC CELL

Genome-wide expression analysis reveals TORC1-dependent and -independent functions of Sch9

(2008) Bart Smets et al.   FEMS YEAST RESEARCH

Thematic Review Series: Sphingolipids. ISC1(inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases

(2008) Nabil Matmati et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Sphingolipids.New insights into sphingolipid metabolism and function in budding yeast

(2008) Robert C. Dickson   JOURNAL OF LIPID RESEARCH

Isc1p Plays a Key Role in Hydrogen Peroxide Resistance and Chronological Lifespan through Modulation of Iron Levels and Apoptosis

(2007) Teresa Almeida et al.   MOLECULAR BIOLOGY OF THE CELL