Translational control of aberrant stress responses as a hallmark of cancer

The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

(2017) Nicholas Burwick et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

(2017) Zhen Shi et al.   MOLECULAR CELL

Codon optimality, bias and usage in translation and mRNA decay

(2017) Gavin Hanson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA modifications and structures cooperate to guide RNA–protein interactions

(2017) Cole J.T. Lewis et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

(2017) Ian R. Mackenzie et al.   NEURON

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation

(2017) Andrew M. Bogorad et al.   NUCLEIC ACIDS RESEARCH

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance

(2017) Moiez Ali et al.   Nature Communications

The RNA Modification N 6 -methyladenosine and Its Implications in Human Disease

(2017) Pedro J. Batista   GENOMICS PROTEOMICS & BIOINFORMATICS

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

(2016) Asad Jan et al.   ACTA NEUROPATHOLOGICA

Eukaryotic elongation factor 2 kinase as a drug target in cancer and in cardiovascular and neurodegenerative diseases

(2016) Rui Liu et al.   ACTA PHARMACOLOGICA SINICA

Targeting MYC in cancer therapy: RNA processing offers new opportunities

(2016) Cheryl M. Koh et al.   BIOESSAYS

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

(2016) Iok In Christine Chio et al.   CELL

Ribosome Footprint Profiling of Translation throughout the Genome

(2016) Nicholas T. Ingolia   CELL

Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression

(2016) Hani Goodarzi et al.   CELL

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy

(2016) Claire E.J. Moore et al.   CELLULAR SIGNALLING

Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer

(2016) A.G. Duffy et al.   INTERNATIONAL JOURNAL OF CANCER

Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

(2016) Nancy Kedersha et al.   JOURNAL OF CELL BIOLOGY

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

(2016) Shintaro Iwasaki et al.   NATURE

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis

(2016) John R.P. Knight et al.   RNA

Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation

(2016) Witold Szaflarski et al.   Oncotarget

Synergistic antitumor activity of the combination of salubrinal and rapamycin against human cholangiocarcinoma cells

(2016) Xiaofang Zhao et al.   Oncotarget

The double-edged sword of AMPK signaling in cancer and its therapeutic implications

(2015) Sang-Min Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

(2015) John R. P. Knight et al.   BIOCHEMICAL JOURNAL

Regulation and roles of elongation factor 2 kinase

(2015) Christopher G. Proud   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting the eIF4A RNA helicase as an anti-neoplastic approach

(2015) Jennifer Chu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Stress-mediated translational control in cancer cells

(2015) Gabriel Leprivier et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

(2015) Amal M. El-Naggar et al.   CANCER CELL

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

(2015) Y. Feng et al.   CANCER RESEARCH

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function

(2015) Z. Okray et al.   EMBO Molecular Medicine

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

(2015) Syam Prakash Somasekharan et al.   JOURNAL OF CELL BIOLOGY

Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons

(2015) Justin W. Kenney et al.   JOURNAL OF NEUROCHEMISTRY

Codon Bias as a Means to Fine-Tune Gene Expression

(2015) Tessa E.F. Quax et al.   MOLECULAR CELL

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1

(2015) Naotaka Sekiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF4AII is dispensable for miRNA-mediated gene silencing

(2015) Gabriela Galicia-Vázquez et al.   RNA

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) L R Palam et al.   Cell Death & Disease

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

Targeting Mnks for Cancer Therapy

(2015) Jinqiang Hou et al.   Oncotarget

4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis

(2015) Tingfang Yi et al.   Oncotarget

Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

(2015) Yikun Li et al.   NEOPLASIA

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

(2014) Hila Gingold et al.   CELL

Discovery of 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation

(2014) Sarah Diab et al.   ChemMedChem

Germline Quality Control: eEF2K Stands Guard to Eliminate Defective Oocytes

(2014) Hsueh-Ping Chu et al.   DEVELOPMENTAL CELL

A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E

(2014) S. Assouline et al.   HAEMATOLOGICA

A Conserved Loop in the Catalytic Domain of Eukaryotic Elongation Factor 2 Kinase Plays a Key Role in Its Substrate Specificity

(2014) C. E. Moore et al.   MOLECULAR AND CELLULAR BIOLOGY

Eukaryotic Elongation Factor 2 Kinase Activity Is Controlled by Multiple Inputs from Oncogenic Signaling

(2014) X. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Ribosome profiling: new views of translation, from single codons to genome scale

(2014) Nicholas T. Ingolia   NATURE REVIEWS GENETICS

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

(2014) Angelo Gismondi et al.   NUCLEIC ACIDS RESEARCH

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

(2014) Rui Liu et al.   NUCLEIC ACIDS RESEARCH

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK

(2014) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents

(2013) Woon-Kai Low et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

(2013) J. K. Altman et al.   BLOOD

AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors

(2013) M. Rios et al.   CANCER RESEARCH

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

(2013) Rossella Lucá et al.   EMBO Molecular Medicine

Post-transcriptional regulatory networks in immunity

(2013) Pavel Ivanov et al.   IMMUNOLOGICAL REVIEWS

mRNA cycles through hypoxia-induced stress granules in live Drosophila embryonic muscles

(2013) Annelies M.A. van der Laan et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

MEK and the inhibitors: from bench to bedside

(2013) Akintunde Akinleye et al.   Journal of Hematology & Oncology

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation

(2013) Chaomin Sun et al.   NUCLEIC ACIDS RESEARCH

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

(2013) Cristina Barbosa et al.   PLoS Genetics

Regulation of stress granules and P-bodies during RNA virus infection

(2013) Richard E. Lloyd   Wiley Interdisciplinary Reviews-RNA

Ribosome profiling: a Hi-Def monitor for protein synthesis at the genome-wide scale

(2013) Audrey M. Michel et al.   Wiley Interdisciplinary Reviews-RNA

Translational reprogramming in cellular stress response

(2013) Botao Liu et al.   Wiley Interdisciplinary Reviews-RNA

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

mTOR inhibitors in cancer therapy

(2012) Yekaterina Y. Zaytseva et al.   CANCER LETTERS

Translation Regulation as a Therapeutic Target in Cancer: Figure 1.

(2012) Michal Grzmil et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress

(2012) B. Kim et al.   DEVELOPMENT

Small heat shock proteins in cancer therapy and prognosis

(2012) Amina Zoubeidi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production

(2012) M. Takahashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Transient Sequestration of TORC1 into Stress Granules during Heat Stress

(2012) Terunao Takahara et al.   MOLECULAR CELL

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupled Activation and Degradation of eEF2K Regulates Protein Synthesis in Response to Genotoxic Stress

(2012) F. Kruiswijk et al.   Science Signaling

On translational regulation and EMT

(2012) Valentina Evdokimova et al.   SEMINARS IN CANCER BIOLOGY

Translational Control in Cancer Etiology

(2012) D. Ruggero   Cold Spring Harbor Perspectives in Biology

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

(2012) D. Walsh et al.   Cold Spring Harbor Perspectives in Biology

Regulation of mRNA Translation by Signaling Pathways

(2012) P. P. Roux et al.   Cold Spring Harbor Perspectives in Biology

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response

(2012) G. D. Pavitt et al.   Cold Spring Harbor Perspectives in Biology

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation

(2012) Biljana Culjkovic-Kraljacic et al.   Cell Reports

Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis

(2012) Chen-Ju Lin et al.   Cell Reports

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

Reduced proliferation and enhanced migration: Two sides of the same coin? Molecular mechanisms of metastatic progression by YB-1

(2011) Valentina Evdokimova et al.   CELL CYCLE

Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication

(2011) R. Cencic et al.   JOURNAL OF VIROLOGY

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

(2011) Ting Chen et al.   Nature Chemical Biology

Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)

(2011) C. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

The role of IREStrans-acting factors in regulating translation initiation

(2010) Helen A. King et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The chemotherapeutic agent bortezomib induces the formation of stress granules

(2010) Marie-Josée Fournier et al.   Cancer Cell International

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

(2010) C. Lagier-Tourenne et al.   HUMAN MOLECULAR GENETICS

5′-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat

(2010) Taichang Jang et al.   INTERNATIONAL JOURNAL OF CANCER

Translational Regulation of Gene Expression during Conditions of Cell Stress

(2010) Keith A. Spriggs et al.   MOLECULAR CELL

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

(2010) R. Cencic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

(2010) L. Furic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

(2009) Valentina Evdokimova et al.   CANCER CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Stress granules

(2009) Paul Anderson et al.   CURRENT BIOLOGY

PI3K and mTOR inhibitors—a new generation of targeted anticancer agents

(2009) Saskia Brachmann et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase

(2009) Y. Gao et al.   MOLECULAR CANCER THERAPEUTICS

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

A new concept for cancer therapy: out-competing the aggressor

(2008) Thomas S Deisboeck et al.   Cancer Cell International

Reprogramming mRNA translation during stress

(2008) Satoshi Yamasaki et al.   CURRENT OPINION IN CELL BIOLOGY

The RSK factors of activating the Ras/MAPK signaling cascade

(2008) Audrey Carriere   Frontiers in Bioscience-Landmark

Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism

(2008) Regina M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Codependent Functions of RSK2 and the Apoptosis-Promoting Factor TIA-1 in Stress Granule Assembly and Cell Survival

(2008) T.S. Karin Eisinger-Mathason et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY

Splicing mediates the activity of four putative cellular internal ribosome entry sites

(2008) B. T. Baranick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global analysis of cellular protein translation by pulsed SILAC

(2008) Björn Schwanhäusser et al.   PROTEOMICS

Invasion emerges from cancer cell adaptation to competitive microenvironments: Quantitative predictions from multiscale mathematical models

(2008) Vito Quaranta et al.   SEMINARS IN CANCER BIOLOGY