The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma

(2017) Nicholas Burwick et al.   LEUKEMIA RESEARCH

Translation from unconventional 5′ start sites drives tumour initiation

(2017) Ataman Sendoel et al.   NATURE

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

(2016) Mohammad Zarei et al.   DIABETES

Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells

(2016)   MOLECULES AND CELLS

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons

(2016) Eva Ramos-Fernández et al.   Oncotarget

Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival

(2016) Svetlana Saveljeva et al.   Oncotarget

Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis

(2015) Gerard ILL-Raga et al.   ANTIOXIDANTS & REDOX SIGNALING

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)

(2015) Adrian L. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress

(2015) K Rajesh et al.   Cell Death & Disease

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

(2015) Sharon W. Way et al.   Nature Communications

Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

(2015) Bertal H. Aktas et al.   Oncotarget

Tumor suppression by small molecule inhibitors of translation initiation

(2015) Limo Chen et al.   Oncotarget

Small-molecule targeting of translation initiation for cancer therapy

(2015) Bertal H. Aktas et al.   Oncotarget

Translational control by heme-regulated eIF2α kinase during erythropoiesis

(2014) Jane-Jane Chen   CURRENT OPINION IN HEMATOLOGY

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

(2014) Shan Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells

(2014) Y Teng et al.   Cell Death & Disease

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Eukaryotic initiation factor 2  phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism

(2013) C. K. Hahn et al.   BLOOD

Eukaryotic translation initiation factors in cancer development and progression

(2013) Rita Spilka et al.   CANCER LETTERS

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K–Akt signaling and tumor treatment

(2013) Antonis E Koromilas et al.   Future Oncology

Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase

(2013) Ting Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

A New PERKspective on Neurodegeneration

(2013) W. Scheper et al.   Science Translational Medicine

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

(2013) Jeffrey M. Axten et al.   ACS Medicinal Chemistry Letters

Pharmacological targeting of endoplasmic reticulum stress signaling in cancer

(2012) Axel H. Schönthal   BIOCHEMICAL PHARMACOLOGY

Heme-regulated eIF2  kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

(2012) R. N. V. S. Suragani et al.   BLOOD

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

(2012) Mimi A. Trinh et al.   Cell Reports

Identification of new inhibitors of protein kinase R guided by statistical modeling

(2011) Ruslana Bryk et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

(2011) Dharminder Chauhan et al.   CLINICAL CANCER RESEARCH

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants Controlling NMDA Receptor Synaptic Incorporation

(2011) G. P. Storey et al.   JOURNAL OF NEUROSCIENCE

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

(2011) Ting Chen et al.   Nature Chemical Biology

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of PKR/eIF2α Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer

(2011) Yong He et al.   PLoS One

Akt Determines Cell Fate Through Inhibition of the PERK-eIF2  Phosphorylation Pathway

(2011) Z. Mounir et al.   Science Signaling

Akt inhibitors in clinical development for the treatment of cancer

(2010) Sumanta Kumar Pal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Investigation of the eIF2α phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells

(2010) Azmi Yerlikaya et al.   MOLECULAR BIOLOGY

Hepatic Heme-Regulated Inhibitor (HRI) Eukaryotic Initiation Factor 2  Kinase: A Protagonist of Heme-Mediated Translational Control of CYP2B Enzymes and a Modulator of Basal Endoplasmic Reticulum Stress Tone

(2010) P. Acharya et al.   MOLECULAR PHARMACOLOGY

Inhibition of eIF2α Dephosphorylation Maximizes Bortezomib Efficiency and Eliminates Quiescent Multiple Myeloma Cells Surviving Proteasome Inhibitor Therapy

(2009) Denis M. Schewe et al.   CANCER RESEARCH

Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2  Phosphorylation Pathway

(2009) Z. Mounir et al.   Science Signaling

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase

(2008) Azmi Yerlikaya et al.   BIOCHEMICAL JOURNAL