eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response
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Title
eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response
Authors
Keywords
eEF2K, Alzheimer’s disease, Aβ oligomers, mRNA translation, Oxidative stress, NRF2
Journal
ACTA NEUROPATHOLOGICA
Volume 133, Issue 1, Pages 101-119
Publisher
Springer Nature
Online
2016-10-17
DOI
10.1007/s00401-016-1634-1
References
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- (2014) Christopher Heise et al. Frontiers in Cellular Neuroscience
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- Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-βVaccine
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- (2011) Zehan Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Guo-li Ming et al. NEURON
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