Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation

The unfolded protein response: mechanisms and therapy of neurodegeneration

(2016) Heather L. Smith et al.   BRAIN

Crystal structure of eukaryotic translation initiation factor 2B

(2016) Kazuhiro Kashiwagi et al.   NATURE

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Visualizing transient dark states by NMR spectroscopy

(2015) Nicholas J. Anthis et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

(2015) M Halliday et al.   Cell Death & Disease

eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics

(2015) Victoria Beilsten-Edmands et al.   Cell Discovery

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Insights into the Architecture of the eIF2Bα/β/δ Regulatory Subcomplex

(2014) Andrew M. Bogorad et al.   BIOCHEMISTRY

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation

(2014) Noel C. Wortham et al.   FASEB JOURNAL

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation

(2013) M. D. Jennings et al.   GENES & DEVELOPMENT

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Dynamic, Ligand-dependent Conformational Change Triggers Reaction of Ribose-1,5-bisphosphate Isomerase fromThermococcus kodakarensisKOD1

(2012) Akira Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the ternary initiation complex aIF2–GDPNP–methionylated initiator tRNA

(2012) Emmanuelle Schmitt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2  (eIF2 ) restricts phosphorylation of Ser51

(2011) M. Dey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukoencephalopathy With Vanishing White Matter: A Review

(2010) Marianna Bugiani et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The  /Gcd7 Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2B), a Guanine Nucleotide Exchange Factor, Is Crucial for Binding eIF2 In Vivo

(2010) K. Dev et al.   MOLECULAR AND CELLULAR BIOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of the C-terminal domain of the ɛ subunit of human translation initiation factor eIF2B

(2010) Jia Wei et al.   Protein & Cell