Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption

Changes in motor function, cognition, and emotion-related behavior after right hemispheric intracerebral hemorrhage in various brain regions of mouse

(2018) Wei Zhu et al.   BRAIN BEHAVIOR AND IMMUNITY

20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis

(2018) Xiaoning Han et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice

(2017) Qian Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Genetic Deletion of Krüppel-Like Factor 11 Aggravates Ischemic Brain Injury

(2017) Xuelian Tang et al.   MOLECULAR NEUROBIOLOGY

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia

(2017) Qiang Li et al.   NEUROBIOLOGY OF DISEASE

Effects of crenolanib, a nonselective inhibitor of PDGFR, in a mouse model of transient middle cerebral artery occlusion

(2017) Jianping Wang et al.   NEUROSCIENCE

Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

(2017) Connor Stonesifer et al.   PROGRESS IN NEUROBIOLOGY

Renoprotective Effects of Carbon Monoxide–Releasing Molecule 3 in Ischemia-Reperfusion Injury and Cisplatin-Induced Toxicity

(2017) Y.E. Yoon et al.   TRANSPLANTATION PROCEEDINGS

Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone

(2017) Jianping Wang et al.   Translational Stroke Research

Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke

(2017) Atsushi Mizuma et al.   Frontiers in Neurology

CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression

(2017) Ming-Horng Tsai et al.   Redox Biology

Multimodality MRI assessment of grey and white matter injury and blood-brain barrier disruption after intracerebral haemorrhage in mice

(2017) Jie Yang et al.   Scientific Reports

Examining the antimicrobial activity and toxicity to animal cells of different types of CO-releasing molecules

(2016) Lígia S. Nobre et al.   DALTON TRANSACTIONS

Cerebroprotection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways

(2016) Tian Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice

(2016) Zhen Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice

(2016) He Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

(2016) Zhen Zhang et al.   MOLECULAR NEUROBIOLOGY

Progesterone Changes VEGF and BDNF Expression and Promotes Neurogenesis After Ischemic Stroke

(2016) Chao Jiang et al.   MOLECULAR NEUROBIOLOGY

Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury

(2016) Yoon Kyung Choi et al.   NATURE MEDICINE

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Interleukin-1 in Stroke

(2016) Oluwaseun A. Sobowale et al.   STROKE

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

CXCR4+CD45− BMMNC subpopulation is superior to unfractionated BMMNCs for protection after ischemic stroke in mice

(2015) Jianping Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

(2015) Md Jamal Uddin et al.   Cellular & Molecular Immunology

A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO

(2015) João D. Seixas et al.   DALTON TRANSACTIONS

Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury

(2015) Xiaoning Han et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke

(2015) Ming-Hsiu Wu et al.   MOLECULAR NEUROBIOLOGY

Gasotransmitters in cancer: from pathophysiology to experimental therapy

(2015) Csaba Szabo   NATURE REVIEWS DRUG DISCOVERY

Origin of Microglia: Current Concepts and Past Controversies

(2015) Florent Ginhoux et al.   Cold Spring Harbor Perspectives in Biology

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

(2015) Miguel Angel Burguillos et al.   Cell Reports

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Carbon monoxide and the CNS: challenges and achievements

(2014) Cláudia S F Queiroga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel lead structures and activation mechanisms for CO-releasing molecules (CORMs)

(2014) U Schatzschneider   BRITISH JOURNAL OF PHARMACOLOGY

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Carbon Monoxide, Hydrogen Sulfide, and Nitric Oxide as Signaling Molecules in the Gastrointestinal Tract

(2014) Gianrico Farrugia et al.   GASTROENTEROLOGY

Carbon monoxide potently prevents ischemia-induced high-mobility group box 1 translocation and release and protects against lethal renal ischemia–reperfusion injury

(2014) Yongle Ruan et al.   KIDNEY INTERNATIONAL

Hemorrhagic Transformation after Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke: Mechanisms, Models, and Biomarkers

(2014) Wei Wang et al.   MOLECULAR NEUROBIOLOGY

Astrocytic Toll-Like Receptor 3 Is Associated with Ischemic Preconditioning- Induced Protection against Brain Ischemia in Rodents

(2014) Lin-na Pan et al.   PLoS One

Hyperlipidemia Attenuates Vascular Endothelial Growth Factor–Induced Angiogenesis, Impairs Cerebral Blood Flow, and Disturbs Stroke Recovery via Decreased Pericyte Coverage of Brain Endothelial Cells

(2013) Anil Zechariah et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

p21-Dependent Protective Effects of a Carbon Monoxide–Releasing Molecule-3 in Pulmonary Hypertension

(2013) Shariq Abid et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MMP-9 Inhibition: a Therapeutic Strategy in Ischemic Stroke

(2013) Mayank Chaturvedi et al.   MOLECULAR NEUROBIOLOGY

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke*

(2011) Andriy Yabluchanskiy et al.   CRITICAL CARE MEDICINE

Retro-orbital injections in mice

(2011) Tal Yardeni et al.   LAB ANIMAL

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Carbon Monoxide–Activated Nrf2 Pathway Leads to Protection Against Permanent Focal Cerebral Ischemia

(2011) Bing Wang et al.   STROKE

Iron Toxicity in Mice with Collagenase-Induced Intracerebral Hemorrhage

(2010) He Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

Low Doses of Carbon Monoxide Protect Against Experimental Focal Brain Ischemia

(2009) Emil Zeynalov et al.   NEUROTOXICITY RESEARCH

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL