Gasotransmitters in cancer: from pathophysiology to experimental therapy

A Focus on Heme Oxygenase-1 (HO-1) Inhibitors

(2016) V. Pittalà et al.   CURRENT MEDICINAL CHEMISTRY

The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer

(2015) Mark R. Hellmich et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor

(2015) Kenji Tsukigawa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S–Nampt

(2015) Elena A. Ostrakhovitch et al.   EXPERIMENTAL CELL RESEARCH

Role of cystathionine β-synthase in human breast Cancer

(2015) Suvajit Sen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tu1975 H2S Inhibition of Cystathionine-β-Synthase (CBS) Using Novel Prodrug Decreases Colorectal Cancer Xenograft Growth With Less Toxicity Than Aminooxyacetic Acid (AOAA)

(2015) John R. Zatarain et al.   GASTROENTEROLOGY

Hydrogen sulfide in lung adenocarcinoma: A tumor cell survival factor, an enhancer of mitochondrial DNA repair and a cellular bioenergetic stimulator

(2015) Bartosz Szczesny et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

H2S-releasing drugs: Anti-inflammatory, cytoprotective and chemopreventative potential

(2015) Burcu Gemici et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

(2014) Anna Lisa Furfaro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity

(2014) Hongzhuan Yin et al.   BMC CANCER

Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance

(2014) Z-W Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2

(2014) E. Lopez-Rivera et al.   CANCER RESEARCH

Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer

(2014) Kun Fan et al.   CELLULAR SIGNALLING

Antiproliferative effects of carbon monoxide on pancreatic cancer

(2014) Libor Vítek et al.   DIGESTIVE AND LIVER DISEASE

Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis

(2014) Naoharu Takano et al.   MOLECULAR CANCER RESEARCH

Site-directed delivery of nitric oxide to cancers

(2014) Kavita Sharma et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer

(2014) Wagdi Elsheikh et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

P19 Cysthionine-β-synthetase inhibition in combination with standard-chemotherapy decreases colorectal cancer metastasis to the liver

(2014) Celia Chao et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Role of the cystathionineγlyase/hydrogen sulfide pathway in human melanoma progression

(2014) Elisabetta Panza et al.   Pigment Cell & Melanoma Research

A H2S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells

(2014) Reiko Sanokawa-Akakura et al.   PLoS One

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

(2014) J. L. Heinecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase II study. Concurrent chemotherapy and radiotherapy with nitroglycerin in locally advanced non-small cell lung cancer

(2014) Oscar Arrieta et al.   RADIOTHERAPY AND ONCOLOGY

Is Nitric Oxide (NO) the Last Word in Radiosensitization? A Review

(2014) Bryan T. Oronsky et al.   Translational Oncology

Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation

(2014) E. Stamellou et al.   Redox Biology

Applications for nitric oxide in halting proliferation of tumor cells

(2013) Melissa M. Reynolds et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CORM-3, a water soluble CO-releasing molecule, uncouples mitochondrial respiration via interaction with the phosphate carrier

(2013) Romain Long et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

(2013) Antonia Asimakopoulou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

(2013) Csaba Szabo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

(2013) B. Wegiel et al.   CANCER RESEARCH

Fractionated radiation-induced nitric oxide promotes expansion of glioma stem-like cells

(2013) Rae-Kwon Kim et al.   CANCER SCIENCE

The yin and yang of nitric oxide in cancer progression

(2013) A. J. Burke et al.   CARCINOGENESIS

Hydrogen Sulfide Inhibits Abnormal Proliferation of Lymphocytes via AKT/GSK3� Signal Pathway in Systemic Lupus Erythematosus Patients

(2013) Yanfang Han et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

iNOS: A Potential Therapeutic Target for Malignant Glioma

(2013) A. Jahani-Asl et al.   CURRENT MOLECULAR MEDICINE

Molecular mechanisms for the anti-cancer effects of diallyl disulfide

(2013) Lan Yi et al.   FOOD AND CHEMICAL TOXICOLOGY

RETRACTED ARTICLE: Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery

(2013) Hongyan Zhao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Multi-targeted DATS prevents tumor progression and promotes apoptosis in ectopic glioblastoma xenografts in SCID mice via HDAC inhibition

(2013) Gerald C. Wallace et al.   JOURNAL OF NEURO-ONCOLOGY

Nitric oxide-mediated activity in anti-cancer photodynamic therapy

(2013) Valentina Rapozzi et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Inhibition of Tumor Growth and Alteration of Associated Macrophage Cell Type by an HO-1 Inhibitor in Breast Carcinoma-Bearing Mice

(2013) Rui Deng et al.   ONCOLOGY RESEARCH

Light-triggered nitric oxide delivery to malignant sites and infection

(2013) B. Heilman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance

(2013) Sanjib Bhattacharyya et al.   PLoS One

Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

(2013) C. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide

(2013) Wen-Ying Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The accuracy of multiparametric MRI in men with negative biopsy and elevated PSA level—Can it rule out clinically significant prostate cancer?

(2013) Mohamed Abd-Alazeez et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

(2013) Norihiro Shibuya et al.   Nature Communications

Macrophage-tumor cell interactions regulate the function of nitric oxide

(2013) Michal A. Rahat et al.   Frontiers in Physiology

Biomarker-Guided Repurposing of Chemotherapeutic Drugs for Cancer Therapy: A Novel Strategy in Drug Development

(2013) Jan Stenvang et al.   Frontiers in Oncology

Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo

(2012) W. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability

(2012) Benjamin L. Predmore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

(2012) Marie-Pierre Hellio le Graverand et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting Nitric Oxide Signaling with nNOS Inhibitors As a Novel Strategy for the Therapy and Prevention of Human Melanoma

(2012) Zhen Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

NOSH–aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model

(2012) Mitali Chattopadhyay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

(2012) Khosrow Kashfi et al.   BIOCHEMICAL PHARMACOLOGY

Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinoma

(2012) Shaofeng Duan et al.   BIOMATERIALS

Targeting eNOS in Pancreatic Cancer

(2012) B. L. Lampson et al.   CANCER RESEARCH

Nitric oxide release: Part II. Therapeutic applications

(2012) Alexis W. Carpenter et al.   CHEMICAL SOCIETY REVIEWS

The Hsp32 Inhibitors SMA-ZnPP and PEG-ZnPP Exert Major Growth-Inhibitory Effects on D34+/CD38+ and CD34+/CD38- AML Progenitor Cells

(2012) H. Herrmann et al.   CURRENT CANCER DRUG TARGETS

Heme Oxygenase-1 in Tumor Biology and Therapy

(2012) Halina Was et al.   CURRENT DRUG TARGETS

Drug repurposing in pediatrics and pediatric hematology oncology

(2012) Julie Blatt et al.   DRUG DISCOVERY TODAY

Cytoprotective Signaling Associated with Nitric Oxide Upregulation in Tumor Cells Subjected to Photodynamic Therapy-like Oxidative Stress

(2012) Reshma Bhowmick et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2

(2012) Christian Ingo Schwer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Contributions of the microbial hydrogen economy to colonic homeostasis

(2012) Franck Carbonero et al.   Nature Reviews Gastroenterology & Hepatology

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

(2012) C. Coletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen Sulfide: An Endogenous Mediator of Resolution of Inflammation and Injury

(2011) John L. Wallace et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo

(2011) Mitali Chattopadhyay et al.   BIOCHEMICAL PHARMACOLOGY

Heme oxygenase-1: a molecular brake on hepatocellular carcinoma cell migration

(2011) C. Zou et al.   CARCINOGENESIS

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

(2011) Christine E. Eyler et al.   CELL

In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells

(2011) Marco Donia et al.   CELL CYCLE

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

(2011) Matthew Whiteman et al.   CLINICAL SCIENCE

Haem oxygenase-1: non-canonical roles in physiology and pathology

(2011) Anna Grochot-Przeczek et al.   CLINICAL SCIENCE

Novel nitric oxide synthase inhibitors: a patent review

(2011) Jacques Joubert et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Inhibition of VCAM-1 expression in endothelial cells by CORM-3: The role of the ubiquitin–proteasome system, p38, and mitochondrial respiration

(2011) Claudia Bergstraesser et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles

(2011) Hideaki Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

Endothelial Nitric Oxide Synthase Is a Key Mediator of Interleukin-2-Induced Hypotension and Vascular Leak Syndrome

(2011) Wolfram E. Samlowski et al.   JOURNAL OF IMMUNOTHERAPY

PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome

(2011) Yunru Li et al.   JOURNAL OF PATHOLOGY

Antitumor Actions of Ruthenium(III)-Based Nitric Oxide Scavengers and Nitric Oxide Synthase Inhibitors

(2011) F. W. Flitney et al.   MOLECULAR CANCER THERAPEUTICS

Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo

(2011) Ping-Ping Wu et al.   PHYTOMEDICINE

Nitric Oxide Synthase Inhibition Enhances the Antitumor Effect of Radiation in the Treatment of Squamous Carcinoma Xenografts

(2011) Robert J. G. Cardnell et al.   PLoS One

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

(2011) Zheng Wei Lee et al.   PLoS One

H2S Donor, S-Propargyl-Cysteine, Increases CSE in SGC-7901 and Cancer-Induced Mice: Evidence for a Novel Anti-Cancer Effect of Endogenous H2S?

(2011) Kaium MA et al.   PLoS One

Intravesical Chondroitin Sulfate Inhibits Recruitment of Inflammatory Cells in an Acute Acid Damage “Leaky Bladder” Model of Cystitis

(2011) Christopher D. Engles et al.   UROLOGY

Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival

(2010) Nikki Buijs et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The expression and activity of cystathionine-γ-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines

(2010) Halina Jurkowska et al.   AMINO ACIDS

Hydrogen sulfide: its production, release and functions

(2010) Hideo Kimura   AMINO ACIDS

The role of tumour-derived iNOS in tumour progression and angiogenesis

(2010) V Kostourou et al.   BRITISH JOURNAL OF CANCER

Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache

(2010) Hans Olav Høivik et al.   CEPHALALGIA

Targeted Inhibition of Inducible Nitric Oxide Synthase Inhibits Growth of Human Melanoma In vivo and Synergizes with Chemotherapy

(2010) A. G. Sikora et al.   CLINICAL CANCER RESEARCH

Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO

(2010) Sanja Mijatovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activated Macrophages as a Novel Determinant of Tumor Cell Radioresponse: The Role of Nitric Oxide–Mediated Inhibition of Cellular Respiration and Oxygen Sparing

(2010) Heng Jiang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-κB/Snail/YY1/RKIP circuitry

(2010) Benjamin Bonavida et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder

(2010) Miyake   ONCOLOGY REPORTS

Gaseotransmitters: New Frontiers for Translational Science

(2010) C. Szabo   Science Translational Medicine

Nitric Oxide in Cell Survival: A Janus Molecule

(2009) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide

(2009) Michael A Insko et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Novel Experimental Heme Oxygenase-1-Targeted Therapy for Hormone-Refractory Prostate Cancer

(2009) M. A. Alaoui-Jamali et al.   CANCER RESEARCH

Nitric Oxide Synthase Inhibition Enhances the Tumor Vascular-Damaging Effects of Combretastatin A-4 3-O-Phosphate at Clinically Relevant Doses

(2009) G. M. Tozer et al.   CLINICAL CANCER RESEARCH

Nitric oxide delivery to cancer: Why and how?

(2009) Pierre Sonveaux et al.   EUROPEAN JOURNAL OF CANCER

Effect of arginine on angiogenesis induced by human colon cancer: in vitro and in vivo studies

(2009) Chiu-Li Yeh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Molecular control of blood flow and angiogenesis: role of nitric oxide

(2009) W. C. SESSA   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells

(2009) G. Gueron et al.   MOLECULAR CANCER RESEARCH

Hydrogen sulfide is an endogenous stimulator of angiogenesis

(2009) A. Papapetropoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity

(2008) Dirk M. Maybauer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice

(2008) Dominika Nowis et al.   BMC CANCER

Garlic Constituent Diallyl Trisulfide Prevents Development of Poorly Differentiated Prostate Cancer and Pulmonary Metastasis Multiplicity in TRAMP Mice

(2008) S. V. Singh et al.   CANCER RESEARCH

The Carbon Monoxide Diffusing Capacity

(2008) Alan L. Plummer   CHEST

Effects of Aminoguanidine, an Inhibitor of Inducible Nitric Oxide Synthase, on Nitric Oxide Production and Its Metabolites in Healthy Control Subjects, Healthy Smokers, and COPD Patients

(2008) Caterina Brindicci et al.   CHEST

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)

(2008) Ling Li et al.   CIRCULATION

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Use of carbon monoxide as a therapeutic agent: promises and challenges

(2008) Roberta Foresti et al.   INTENSIVE CARE MEDICINE

Tumoricidal activity of high-dose tumor necrosis factor-α is mediated by macrophage-derived nitric oxide burst and permanent blood flow shutdown

(2008) Chandrakala Menon et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice

(2008) Gabriele Sass et al.   INTERNATIONAL JOURNAL OF CANCER

Inducible Nitric Oxide Synthase (iNOS) is Not Required for IL-2???induced Hypotension and Vascular Leak Syndrome in Mice

(2008) Muralidhar Kondapaneni et al.   JOURNAL OF IMMUNOTHERAPY

Exhaled breath analysis: Novel approach for early detection of lung cancer

(2008) Hiang Ping Chan et al.   LUNG CANCER

Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo

(2008) D. Maksimovic-Ivanic et al.   MOLECULAR CANCER THERAPEUTICS

Perivascular nitric oxide gradients normalize tumor vasculature

(2008) Satoshi Kashiwagi et al.   NATURE MEDICINE

Hypoxic tumor cell radiosensitization through nitric oxide

(2008) Mark De Ridder et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitric oxide-induced resistance or sensitization to death in tumor cells

(2008) Jean-François Jeannin et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

NO-donating NSAIDs and cancer: An overview with a note on whether NO is required for their action

(2008) Basil Rigas et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Solid tumor physiology and hypoxia-induced chemo/radio-resistance: Novel strategy for cancer therapy: Nitric oxide donor as a therapeutic enhancer

(2008) Hiroyasu Yasuda   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitric oxide, apoptosis and macrophage polarization during tumor progression

(2008) Andreas Weigert et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY