Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

Antioxidants and HNE in redox homeostasis

(2017) Wojciech Łuczaj et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds

(2017) Bebiana C. Sousa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

(2017) Célia Fourrier et al.   Journal of Neuroinflammation

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases

(2017) Grace Y. Sun et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice

(2017) Pilar Mancera et al.   Nutrients

Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring

(2016) Cai Tie et al.   ANALYTICAL CHEMISTRY

N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update

(2016) Marc-Olivier Trépanier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid peroxidation in the pathogenesis of neuroborreliosis

(2016) Anna Moniuszko-Malinowska et al.   FREE RADICAL BIOLOGY AND MEDICINE

Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells

(2016) Marie-Eve Tremblay et al.   Journal of Neuroinflammation

Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

(2016) Giuseppe Maulucci et al.   MOLECULAR ASPECTS OF MEDICINE

Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2

(2016) Dennis Y. Chuang et al.   NEUROMOLECULAR MEDICINE

On the role of 4-hydroxynonenal in health and disease

(2015) Miklós Csala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid

(2015) Rohini Sidhu et al.   JOURNAL OF LIPID RESEARCH

Calcium-independent phospholipases A2and their roles in biological processes and diseases

(2015) Sasanka Ramanadham et al.   JOURNAL OF LIPID RESEARCH

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

(2015) Grace Y. Sun et al.   PLoS One

The benefit of docosahexaenoic acid for the adult brain in aging and dementia

(2015) Norman Salem et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Tick-borne encephalitis – lipid peroxidation and its consequences

(2015) Wojciech Łuczaj et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal

(2015) Kohji Nagayama et al.   Nutrients

Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives

(2015) Chiara Cipollina   Biomed Research International

Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies

(2014) Irene Paterniti et al.   Journal of Neuroinflammation

Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1

(2014) M. Zhang et al.   JOURNAL OF NEUROSCIENCE

Cellular Membrane Fluidity in Amyloid Precursor Protein Processing

(2014) Xiaoguang Yang et al.   MOLECULAR NEUROBIOLOGY

Role of Cytosolic Phospholipase A2 in Oxidative and Inflammatory Signaling Pathways in Different Cell Types in the Central Nervous System

(2014) Grace Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials

(2014) Giuseppe Grosso et al.   PLoS One

Omega-3 fatty acids and brain resistance to ageing and stress: Body of evidence and possible mechanisms

(2013) I. Denis et al.   AGEING RESEARCH REVIEWS

4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs

(2013) Fumiyuki Nakagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

(2013) Dennis Y Chuang et al.   Journal of Neuroinflammation

4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation

(2013) Atsushi Ishikado et al.   PLoS One

Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?

(2013) Adina T. Michael-Titus et al.   TRENDS IN NEUROSCIENCES

Shotgun Lipidomics Analysis of 4-Hydroxyalkenal Species Directly from Lipid Extracts after One-Step in Situ Derivatization

(2012) Miao Wang et al.   ANALYTICAL CHEMISTRY

Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways

(2012) Ya-Chen Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal

(2012) Ying Huang et al.   Cell and Bioscience

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia

(2011) Wenwen Sheng et al.   Journal of Neuroinflammation

Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells

(2011) Maria Antonietta Ajmone-Cat et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells

(2010) Atsushi Ishikado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: Make some room HNE…

(2010) Eric K. Long et al.   FREE RADICAL BIOLOGY AND MEDICINE

Docosahexaenoic Acid Suppresses Neuroinflammatory Responses and Induces Heme Oxygenase-1 Expression in BV-2 Microglia: Implications of Antidepressant Effects for Omega-3 Fatty Acids

(2010) Dah-Yuu Lu et al.   NEUROPSYCHOPHARMACOLOGY

Regulatory role of cytosolic phospholipase A2α in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Aβ1-42in microglia

(2009) I. Szaingurten-Solodkin et al.   GLIA

The emerging role of group VI calcium-independent phospholipase A2in releasing docosahexaenoic acid from brain phospholipids: Fig. 1.

(2008) Joshua T. Green et al.   JOURNAL OF LIPID RESEARCH

Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization

(2008) Véronique De Smedt-Peyrusse et al.   JOURNAL OF NEUROCHEMISTRY