Article
Nutrition & Dietetics
Bojung Seo, Keming Yang, Ka Kahe, Abrar A. Qureshi, Andrew T. Chan, Immaculata De Vivo, Eunyoung Cho, Edward L. Giovannucci, Hongmei Nan
Summary: This study suggests that higher intakes of DHA and consumption of canned tuna are associated with longer leukocyte telomere length (LTL) in US males.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Andrew Elagizi, Carl J. Lavie, Evan O'Keefe, Keri Marshall, James H. O'Keefe, Richard V. Milani
Summary: Interest in the potential cardiovascular benefits of omega-3 polyunsaturated fatty acids (omega-3) began in the 1940s, but there has been controversy due to conflicting results among studies and meta-analyses. Recent large, randomized trials showed discordant findings, with one using a higher dose of omega-3 showing a significant reduction in cardiovascular events. The conflicting results in clinical trials may be due to inadequate dosing of omega-3 and aggressive treatment with other effective therapies.
Article
Biochemistry & Molecular Biology
Emanuela Talamonti, Anders Jacobsson, Valerio Chiurchiu
Summary: Omega-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), play important roles in various biological processes and have numerous health benefits. Deficiency in Elovl2, a key enzyme involved in DHA synthesis, leads to decreased DHA levels, increased brain inflammation, and heightened pro-inflammatory responses in T lymphocytes. Additionally, DHA deficiency affects the interaction between dendritic cells (DC) and T cells. Therefore, DHA plays a crucial role in regulating adaptive immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marco Fazzari, Steven R. Woodcock, Pascal Rowart, Karina Ricart, Jack R. Lancaster Jr, Rakesh Patel, Dario A. Vitturi, Bruce A. Freeman, Francisco J. Schopfer
Summary: This study identified nitro-nitrate ester-containing lipids as intermediates in unsaturated fatty acid nitration reactions in rat stomach, leading to the production of anti-inflammatory and tissue-protective signaling mediators. These observations provide new insight into the mechanisms of unsaturated fatty acid nitration and expand the scope of endogenous products resulting from nitrogen oxides metabolic reactions.
Article
Endocrinology & Metabolism
Adeyemi Fatai Odetayo, Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Summary: In this study, the role and molecular mechanism of O3FA in BPF-induced testicular dysfunction in male rats were investigated. It was found that both low and high doses of O3FA improved sperm quality and hormonal imbalance caused by BPF. Additionally, co-administration of BPF with O3FA effectively reduced redox imbalance, inflammatory response, and apoptosis in the testicles.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Meghan Dempsey, Michelle S. Rockwell, Laurel M. Wentz
Summary: The majority of the population lack adequate omega-3 fatty acids (n-3 FA), leading to global deficiencies and poor omega-3 status. This study aimed to evaluate the effect of n-3 FA interventions on omega3-index (O3i) and estimate sufficient intake to meet recommendations.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Tomohiko Shimizu, Tsugumichi Saito, Haruka Aoki-Saito, Shuichi Okada, Hiroyuki Ikeda, Takashi Nakakura, Hayato Fukuda, Syota Arai, Kouichi Fujiwara, Yasuyo Nakajima, Kazuhiro Horiguchi, Sayaka Yamada, Emi Ishida, Takeshi Hisada, Satoshi Shuto, Masanobu Yamada
Summary: The study showed that resolvin E3 (RvE3) may improve insulin sensitivity and enhance glucose uptake in adipocytes by activating the PI3K/Akt signaling pathways, potentially regulating glucose homeostasis and serving as a therapeutic target for treating obesity-associated diabetes.
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
R. E. Akhigbe, M. A. Hamed, A. F. Odetayo, T. M. Akhigbe, A. F. Ajayi, F. A. H. Ajibogun
Summary: In a rat model of testicular torsion/detorsion (T/D), administration of omega-3 fatty acid attenuated damage to testicular and sperm cells, increased serum testosterone levels, and may be beneficial in protecting against T/D-related oxido-inflammatory damage and male infertility.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Nutrition & Dietetics
Magdalena Ogluszka, Pawel Lipinski, Rafal R. Starzynski
Summary: Telomeres play a key role in protecting chromosome ends and maintaining genome stability, but they shorten with aging. Short telomeres are associated with age-related diseases, but the variability in telomere shortening suggests it is modifiable. Studies have explored the impact of omega-3 fatty acids on telomere shortening, with most indicating a beneficial effect on telomere length.
Article
Food Science & Technology
Hechun Liu, Feng Wang, Hui Xia, Da Pan, Ligang Yang, Shaokang Wang, Feng Zhao, Guiju Sun
Summary: This study aimed to determine the effects of different sources of m-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM patients with dyslipidemia. The results showed that plant-derived m-3 PUFAs were more effective at controlling blood glucose levels, while animal-derived m-3 PUFAs were more effective at lowering triglyceride levels. Moreover, intake of animal-derived m-3 PUFAs led to higher levels of large HDL-C subfractions and lower levels of small HDL-C subfractions compared to plant-derived m-3 PUFAs. Both animal and plant-derived m-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Agriculture, Dairy & Animal Science
A. Irawan, N. Ningsih, Hafizuddin, R. K. Rusli, W. P. S. Suprayogi, N. Akhirini, R. F. Hadi, W. Setyono, A. Jayanegara
Summary: This meta-analysis evaluated the effects of dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) sources on the formation of n-3 PUFA contents in eggs, and identified predictors for DHA formation. The study confirmed that ALA, n-3 PUFA, and the ratio of LA/ALA can be used as predictors for the formation of n-3 fatty acids in eggs. Fish oil showed the highest prediction model for DHA formation.
Article
Food Science & Technology
Chiara Magoni, Stefano Bertacchi, Chiara Maria Giustra, Lorenzo Guzzetti, Radiana Cozza, Michele Ferrari, Anna Torelli, Matteo Marieschi, Danilo Porro, Paola Branduardi, Massimo Labra
Summary: This paper reviews the sustainability and supply chain of omega-3 fatty acids production from microalgae. It highlights the importance of microalgal bioprospecting, engineering approaches, and environmental influence in achieving sustainable production. Additionally, the strategy to promote consumer acceptance of algae-based products is crucial for substituting current sources of omega-3 fatty acids.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marco Buscetta, Serena Di Vincenzo, Monica Miele, Ester Badami, Elisabetta Pace, Chiara Cipollina
Article
Chemistry, Analytical
B. Patella, M. Buscetta, S. Di Vincenzo, M. Ferraro, G. Aiello, C. Sunseri, E. Pace, R. Inguanta, C. Cipollina
Summary: Increased oxidative burden is linked to the pathogenesis of inflammatory diseases, with macrophages playing a role in ROS generation. A sensor for H2O2 detection released by cells in culture supernatants was evaluated for sensitivity and selectivity, and its results were consistent with those obtained using flow cytometry. It has the potential to be used for real-time monitoring of oxidative stress without impacting cell viability.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Pharmacology & Pharmacy
Serena Di Vincenzo, Claudia Sangiorgi, Maria Ferraro, Marco Buscetta, Chiara Cipollina, Elisabetta Pace
Summary: This study investigated the effects of cigarette smoke on different types of lung cancer cell lines and found that it induces oxidative stress and mitochondrial damage, leading to metabolic reprogramming. Cigarette smoke exposure also downregulates the tumor suppressor FOXO3a, promoting tumor migration and progression.
Review
Biochemistry & Molecular Biology
Chiara Cipollina, Andreina Bruno, Salvatore Fasola, Marta Cristaldi, Bernardo Patella, Rosalinda Inguanta, Antonio Vilasi, Giuseppe Aiello, Stefania La Grutta, Claudia Torino, Elisabetta Pace
Summary: Exposure of airway epithelium to environmental insults, such as cigarette smoke, leads to increased oxidative stress, which promotes the development of chronic lung diseases. Oxidative stress disrupts antioxidant defenses, affects cellular autophagy and survival regulatory mechanisms, leading to cell senescence. These events are exacerbated by inflammation driven by oxidative stress. Various models of bronchial epithelial cells are used to study the mechanisms and functions altered by cigarette smoke exposure and to test the efficacy of antioxidants. This review provides a comprehensive synthesis of in-vitro and ex-vivo studies from 2011 to 2021, investigating the molecular and cellular mechanisms triggered by cigarette smoke exposure in bronchial epithelial cells, commonly used experimental models, and the mechanisms of action of cellular antioxidant systems, as well as natural and synthetic antioxidant compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Giuseppina Chiappara, Serena Di Vincenzo, Claudia Sangiorgi, Caterina Di Sano, Claudia D'Anna, Giovanni Zito, Chiara Cipollina, Patrizio Vitulo, Alessandro Bertani, Elisabetta Pace
Summary: This study showed that cigarette smoke may promote adenocarcinoma progression by activating the Notch-1 pathway, highlighting its role as a hallmark of lung cancer progression and a potential target for lung cancer treatment.
TOXICOLOGY LETTERS
(2022)
Article
Chemistry, Physical
Bernardo Patella, Nadia Moukri, Gaia Regalbuto, Chiara Cipollina, Elisabetta Pace, Serena Di Vincenzo, Giuseppe Aiello, Alan O'Riordan, Rosalinda Inguanta
Summary: In this study, an immunosensor for detecting human IgG was developed using an electrochemical sandwich-type system. Zinc oxide nanorods were fabricated using a simple and inexpensive method, and reduced graphene oxide was used to immobilize the antibodies. The immunosensor showed good sensitivity and a low detection limit.
Article
Biochemistry & Molecular Biology
Marco Buscetta, Marta Cristaldi, Maura Cimino, Agnese La Mensa, Paola Dino, Fabio Bucchieri, Francesca Rappa, Santina Amato, Tommaso Silvano Aronica, Elisabetta Pace, Alessandro Bertani, Chiara Cipollina
Summary: The mechanisms and consequences of GSDMD activation in cigarette smoke-associated inflammation and lung disease are not well understood. This study shows that cigarette smoke extract (CSE) can activate caspase-1 and induce GSDMD cleavage and increased cell permeability. The activation of caspase-4 and caspase-8 by CSE further promotes GSDMD cleavage. These findings suggest that ASC-independent activation of caspase-1, -4, and -8 and subsequent GSDMD cleavage may contribute to macrophage dysfunction and chronic inflammation in the lungs of smokers.
Article
Chemistry, Analytical
Bernardo Patella, Serena Di Vincenzo, Claudio Zanca, Luciano Bollaci, Maria Ferraro, Maria Rita Giuffre, Chiara Cipollina, Maria Giuseppina Bruno, Giuseppe Aiello, Michele Russo, Rosalinda Inguanta, Elisabetta Pace
Summary: This study investigated the effect of different cell culture media on the electrochemical quantification of H2O2. Using LSV technique, the researchers successfully quantified oxidative stress without dilution in various media and evaluated the long-term stability of the sensor.
Article
Biochemistry & Molecular Biology
Serena Di Vincenzo, Dennis K. Ninaber, Chiara Cipollina, Maria Ferraro, Pieter S. Hiemstra, Elisabetta Pace
Summary: This study found that cigarette smoke inhibits physiological epithelial wound repair by interfering with the normal epithelial-mesenchymal transition process and the Notch-1 pathway.
Article
Infectious Diseases
Serena Di Vincenzo, Maria Ferraro, Simona Taverna, Velia Malizia, Marco Buscetta, Chiara Cipollina, Valentina Lazzara, Paola Pinto, Marco Bassano, Stefania La Grutta, Elisabetta Pace
Summary: Macrophage polarization is a process where specific features are acquired by macrophages, represented by M1 and M2 polarization. M1 macrophages include IL-6, IL-1 beta, IL-12, and IL-8, while M2 cytokines include TGF-beta. This study explores the effects of tyndallized bacteria (TB) on macrophage polarization.
Meeting Abstract
Respiratory System
E. Pace, S. Di Vincenzo, S. Taverna, M. Ferraro, M. Buscetta, C. Cipollina, S. La Grutta
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
Serena Di Vincenzo, Bernardo Patella, Maria Ferraro, Luciano Bollaci, Marco Buscetta, Chiara Cipollina, Giuseppe Aiello, Rosalinda Inguanta, Elisabetta Pace
EUROPEAN RESPIRATORY JOURNAL
(2021)
Meeting Abstract
Respiratory System
Giuseppina Chiappara, Claudia Sangiorgi, Caterina Di Sano, Claudia D'Anna, Serena Di Vincenzo, Giovanni Zito, Chiara Cipollina, Alessandro Bertani, Patrizio Vitulo, Elisabetta Pace
EUROPEAN RESPIRATORY JOURNAL
(2020)
Meeting Abstract
Respiratory System
Marco Busceta, Serena Di Vincenzo, Elisabetta Pace, Chiara Cipollina
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Immunology
Giorgio Bertolazzi, Chiara Cipollina, Panayiotis V. Benos, Michele Tumminello, Claudia Coronnello
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)