Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

Inhibition of microglial activation by elderberry extracts and its phenolic components

(2015) Agnes Simonyi et al.   LIFE SCIENCES

Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2

(2015) X. Yang et al.   NEUROSCIENCE

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

(2015) Grace Y. Sun et al.   PLoS One

Cytosolic phospholipase A2protein as a novel therapeutic target for spinal cord injury

(2014) Nai-Kui Liu et al.   ANNALS OF NEUROLOGY

Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells

(2014) Jinghua Jiang et al.   PLoS One

Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathway

(2013) Chang-Hee Kang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

(2013) Dennis Y Chuang et al.   Journal of Neuroinflammation

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Inhibition of cytosolic phospholipase A2 alpha protects against focal ischemic brain damage in mice

(2012) Jian Zhang et al.   BRAIN RESEARCH

Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation

(2012) Deepak Kumar Kaushik et al.   Journal of Neuroinflammation

Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists

(2012) Rachel Ribeiro et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter

(2011) Adam C. Vana et al.   EXPERIMENTAL NEUROLOGY

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia

(2011) Wenwen Sheng et al.   Journal of Neuroinflammation

Protective and Restorative Effects of Magnolol on Neurotoxicity in Mice with 6-Hydroxydopamine-Induced Hemiparkinsonism

(2011) Hwei-Hsien Chen et al.   Neurodegenerative Diseases

Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation

(2011) S. Wang et al.   NEUROSCIENCE

Therapeutic applications of compounds in the Magnolia family

(2011) Young-Jung Lee et al.   PHARMACOLOGY & THERAPEUTICS

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice.

(2010) Chen Chang-Mu et al.   BEHAVIORAL NEUROSCIENCE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

(2010) Fang Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibitory Effect of Magnolol on TPA-Induced Skin Inflammation and Tumor Promotion in Mice

(2010) Daih-Huang Kuo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia

(2010) Tsung-Kuei Kao et al.   LIFE SCIENCES

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Anti-inflammatory effect of 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis through inhibition of NF-κB

(2009) Ju Hoon Oh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neuroprotective Effects of Onion Extract and Quercetin Against Ischemic Neuronal Damage in the Gerbil Hippocampus

(2009) In Koo Hwang et al.   JOURNAL OF MEDICINAL FOOD

Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury

(2009) Wenlong Huang et al.   JOURNAL OF NEUROTRAUMA

Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia

(2008) Xiao-dong Pan et al.   BIOCHEMICAL PHARMACOLOGY

Phospholipase A2structure/function, mechanism, and signaling

(2008) John E. Burke et al.   JOURNAL OF LIPID RESEARCH

Botanical Phenolics and Brain Health

(2008) Albert Y. Sun et al.   NEUROMOLECULAR MEDICINE

The relationship between the fatty acid composition of immune cells and their function

(2008) Philip C. Calder   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents

(2007) Qun Xu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY