Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

(2016) Ya Wang et al.   ACS Chemical Neuroscience

Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases

(2016) Amanda Lo Van et al.   BIOCHIMIE

Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro

(2016) C. Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid

(2016) J. L. Tremoleda et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice

(2016) Kathryn E. Hopperton et al.   Journal of Neuroinflammation

Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells

(2016) Marie-Eve Tremblay et al.   Journal of Neuroinflammation

Dietary Docosahexaenoic Acid Improves Cognitive Function, Tissue Sparing, and Magnetic Resonance Imaging Indices of Edema and White Matter Injury in the Immature Rat after Traumatic Brain Injury

(2016) Michelle E. Schober et al.   JOURNAL OF NEUROTRAUMA

Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion

(2016) Alex P. Kitson et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Docosahexaenoic acid inhibitsHelicobacter pylori-induced STAT3 phosphorylation through activation of PPARγ

(2016) Hyeon-Geun Ji et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Modulation of brain PUFA content in different experimental models of mice

(2016) Corinne Joffre et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Long Chain Omega-3 Polyunsaturated Fatty Acid Supplementation Alleviates Doxorubicin-Induced Depressive-Like Behaviors and Neurotoxicity in Rats: Involvement of Oxidative Stress and Neuroinflammation

(2016) Yan-Qin Wu et al.   Nutrients

Intravenous Treatment with a Long-Chain Omega-3 Lipid Emulsion Provides Neuroprotection in a Murine Model of Ischemic Stroke – A Pilot Study

(2016) Dirk Berressem et al.   PLoS One

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

(2015) Christoph Garbers et al.   CURRENT OPINION IN IMMUNOLOGY

Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model

(2015) Marc-Olivier Trépanier et al.   EPILEPSY & BEHAVIOR

Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology

(2015) Philip Chang et al.   Journal of Neuroinflammation

Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid

(2015) Mayssa Hachem et al.   MOLECULAR NEUROBIOLOGY

Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

(2015) M H Rapaport et al.   MOLECULAR PSYCHIATRY

Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment

(2015) Jean-Christophe Delpech et al.   NEUROPSYCHOPHARMACOLOGY

Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain

(2015) M. Lagarde et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

(2015) Chuck T. Chen et al.   Scientific Reports

Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes

(2014) Charlotte Madore et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoidN-docosahexaenoylethanolamine (DHEA) in macrophages

(2014) Jocelijn Meijerink et al.   BRITISH JOURNAL OF PHARMACOLOGY

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

(2014) Lei Liu et al.   JOURNAL OF LIPID RESEARCH

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide

(2013) C. Madore et al.   BRAIN BEHAVIOR AND IMMUNITY

A positive feedback loop between STAT3 and cyclooxygenase-2 gene may contribute toHelicobacter pylori-associated human gastric tumorigenesis

(2013) Hua Xiong et al.   INTERNATIONAL JOURNAL OF CANCER

Unesterified docosahexaenoic acid is protective in neuroinflammation

(2013) Sarah K. Orr et al.   JOURNAL OF NEUROCHEMISTRY

Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells

(2013) Tzu-Ming Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord

(2013) Y. Lu et al.   NEUROSCIENCE

Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: Relationship with interleukin-6

(2012) Francis E. Lotrich et al.   BRAIN BEHAVIOR AND IMMUNITY

N-acyl amines of docosahexaenoic acid and othern-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads

(2012) Jocelijn Meijerink et al.   BRITISH JOURNAL OF PHARMACOLOGY

Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice

(2012) Virginie F. Labrousse et al.   PLoS One

n-3 Polyunsaturated fatty acids in animal models with neuroinflammation

(2012) Sarah K. Orr et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial

(2011) Janice K. Kiecolt-Glaser et al.   BRAIN BEHAVIOR AND IMMUNITY

Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice

(2011) Aurélie Moranis et al.   BRAIN BEHAVIOR AND IMMUNITY

The Salutary Effects of DHA Dietary Supplementation on Cognition, Neuroplasticity, and Membrane Homeostasis after Brain Trauma

(2011) Aiguo Wu et al.   JOURNAL OF NEUROTRAUMA

Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain

(2011) Artemis P. Simopoulos   MOLECULAR NEUROBIOLOGY

Cognitive and Emotional Alterations Are Related to Hippocampal Inflammation in a Mouse Model of Metabolic Syndrome

(2011) Anne-Laure Dinel et al.   PLoS One

Fatty acid transport into the brain: Of fatty acid fables and lipid tails

(2011) Ryan W. Mitchell et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Accumulation of Dietary Docosahexaenoic Acid in the Brain Attenuates Acute Immune Response and Development of Postischemic Neuronal Damage

(2011) Mélanie Lalancette-Hébert et al.   STROKE

Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice

(2010) R. Lopez-Vales et al.   JOURNAL OF NEUROSCIENCE

DHA Metabolism: Targeting the Brain and Lipoxygenation

(2010) M. Picq et al.   MOLECULAR NEUROBIOLOGY

Docosahexaenoic Acid Suppresses Neuroinflammatory Responses and Induces Heme Oxygenase-1 Expression in BV-2 Microglia: Implications of Antidepressant Effects for Omega-3 Fatty Acids

(2010) Dah-Yuu Lu et al.   NEUROPSYCHOPHARMACOLOGY

Cytokine-induced depression during IFN-α treatment: The role of IL-6 and sleep quality

(2009) Aric A. Prather et al.   BRAIN BEHAVIOR AND IMMUNITY

Impaired Interleukin-1β and c-Fos Expression in the Hippocampus Is Associated with a Spatial Memory Deficit in P2X7 Receptor-Deficient Mice

(2009) Virginie F. Labrousse et al.   PLoS One

Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice

(2008) Rozenn Mingam et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization

(2008) Véronique De Smedt-Peyrusse et al.   JOURNAL OF NEUROCHEMISTRY

Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2

(2008) J. Audoy-Remus et al.   JOURNAL OF NEUROSCIENCE