Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

(2015) Lu-ting Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New compound, 5-O-isoferuloyl-2-deoxy-D-ribono-γ-lacton from Clematis mandshurica: Anti-inflammatory effects in lipopolysaccharide-stimulated BV2 microglial cells

(2015) Matharage Gayani Dilshara et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia

(2015) Wanqiang Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Differential effects of quercetin on hippocampus-dependent learning and memory in mice fed with different diets related with oxidative stress

(2015) Shu-Fang Xia et al.   PHYSIOLOGY & BEHAVIOR

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

(2014) Li Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway

(2014) Constance Lay Lay Saw et al.   FOOD AND CHEMICAL TOXICOLOGY

In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity

(2014) T. M. Henagan et al.   Genes and Nutrition

Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo

(2014) Eun Jung Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

(2014) Adam D Bachstetter et al.   Journal of Neuroinflammation

NitroDIGE analysis reveals inhibition of protein S-nitrosylation by epigallocatechin gallates in lipopolysaccharide-stimulated microglial cells

(2014) Zhe Qu et al.   Journal of Neuroinflammation

The Neoflavonoid Latifolin Isolated from MeOH Extract ofDalbergia odoriferaAttenuates Inflammatory Responses by Inhibiting NF-κB ActivationviaNrf2-Mediated Heme Oxygenase-1 Expression

(2014) Dong-Sung Lee et al.   PHYTOTHERAPY RESEARCH

Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells

(2014) Jinghua Jiang et al.   PLoS One

Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling

(2013) Lingrui Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice

(2013) Eun Jung Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Heme Catabolism by Heme Oxygenase-1 Confers Host Resistance to Mycobacterium Infection

(2013) Sandro Silva-Gomes et al.   INFECTION AND IMMUNITY

Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathway

(2013) Chang-Hee Kang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1

(2013) Matharage Gayani Dilshara et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

(2013) Dennis Y Chuang et al.   Journal of Neuroinflammation

A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells

(2013) Riyako Terazawa et al.   PHARMACOLOGICAL RESEARCH

Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-κB pathway

(2013) Guang-Lin Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells

(2012) Hyo-Hyun Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats

(2012) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

β-Ionone attenuates LPS-induced pro-inflammatory mediators such as NO, PGE2 and TNF-α in BV2 microglial cells via suppression of the NF-κB and MAPK pathway

(2012) Chang-Hee Kang et al.   TOXICOLOGY IN VITRO

Therapeutic Potential of Quercetin to Decrease Blood Pressure: Review of Efficacy and Mechanisms

(2012) Abigail J. Larson et al.   Advances in Nutrition

Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes

(2011) I. M. A. Ernst et al.   BRITISH JOURNAL OF NUTRITION

Fisetin induces Nrf2-mediated HO-1 expression through PKC-δ and p38 in human umbilical vein endothelial cells

(2011) Seung Eun Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia

(2011) Wenwen Sheng et al.   Journal of Neuroinflammation

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Immunoregulatory effects of HO-1: how does it work?

(2009) Miguel P Soares et al.   CURRENT OPINION IN PHARMACOLOGY

Neuroprotective Effects of Onion Extract and Quercetin Against Ischemic Neuronal Damage in the Gerbil Hippocampus

(2009) In Koo Hwang et al.   JOURNAL OF MEDICINAL FOOD

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

(2008) S Nair et al.   BRITISH JOURNAL OF CANCER

Health effects of quercetin: From antioxidant to nutraceutical

(2008) Agnes W. Boots et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Botanical Phenolics and Brain Health

(2008) Albert Y. Sun et al.   NEUROMOLECULAR MEDICINE

Hormetic Dietary Phytochemicals

(2008) Tae Gen Son et al.   NEUROMOLECULAR MEDICINE

Pharmacological and Clinical Aspects of Heme Oxygenase

(2008) N. G. Abraham et al.   PHARMACOLOGICAL REVIEWS