δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin

Functional identification of islet cell types by electrophysiological fingerprinting

(2017) Linford J. B. Briant et al.   Journal of the Royal Society Interface

Paracrine regulation of glucagon secretion: the β/α/δ model

(2016) Margaret Watts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop

(2016) Kevin Michalski et al.   JOURNAL OF GENERAL PHYSIOLOGY

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

(2016) Hongyan Shuai et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

(2016) Anna Muszkiewicz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Glucose control of glucagon secretion—‘There’s a brand-new gimmick every year’

(2016) Erik Gylfe   UPSALA JOURNAL OF MEDICAL SCIENCES

Glucagon secretion from pancreatic α-cells

(2016) Linford Briant et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells

(2016) Morten Gram Pedersen et al.   Scientific Reports

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

(2016) Joana Almaça et al.   Cell Reports

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea

(2016) Serena Cerritelli et al.   PLoS One

Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles

(2015) Nora S. Kayton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells

(2015) Kristoffer L. Egerod et al.   ENDOCRINOLOGY

Alpha-, Delta- and PP-cells

(2015) Melissa F. Brereton et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Role of Connexins and Pannexins in the Pancreas

(2015) Valentina Cigliola et al.   PANCREAS

The Beta Cell in Its Cluster: Stochastic Graphs of Beta Cell Connectivity in the Islets of Langerhans

(2015) Deborah A. Striegel et al.   PLoS Computational Biology

Modeling the Pancreatic α-Cell: Dual Mechanisms of Glucose Suppression of Glucagon Secretion

(2014) Margaret Watts et al.   BIOPHYSICAL JOURNAL

New insights into the role of connexins in pancreatic islet function and diabetes

(2014) Nikki L. Farnsworth et al.   FEBS LETTERS

A Conserved Rule for Pancreatic Islet Organization

(2014) Danh-Tai Hoang et al.   PLoS One

Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2

(2014) Thomas M Reinbothe et al.   Islets

Mathematical Modeling of Heterogeneous Electrophysiological Responses in Human β-Cells

(2014) Michela Riz et al.   PLoS Computational Biology

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

(2013) Quan Zhang et al.   Cell Metabolism

Glucose Control of Glucagon Secretion: There Is More to It Than KATP Channels

(2013) E. Gylfe   DIABETES

Glucose regulation of glucagon secretion

(2013) Erik Gylfe et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ

(2013) Jacques-Antoine Haefliger et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study

(2013) John Walmsley et al.   PLoS One

Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice

(2012) C. P. F. Carvalho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

(2012) Balrik Kailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine

(2012) Changhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploiting mathematical models to illuminate electrophysiological variability between individuals

(2012) Amrita X. Sarkar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Paracrine and autocrine interactions in the human islet: More than meets the eye

(2012) Alejandro Caicedo   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tales of a Dirty Drug: Carbenoxolone, Gap Junctions, and Seizures

(2012) Barry W. Connors   Epilepsy Currents

A computational systems analysis of factors regulating α cell glucagon secretion

(2012) Leonid E. Fridlyand et al.   Islets

The role of dysregulated glucagon secretion in type 2 diabetes

(2011) D. D'Alessio   DIABETES OBESITY & METABOLISM

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

(2011) J. N. Walker et al.   DIABETES OBESITY & METABOLISM

Multiple models to capture the variability in biological neurons and networks

(2011) Eve Marder et al.   NATURE NEUROSCIENCE

Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes

(2011) German Kilimnik et al.   PLoS One

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Glucose Suppression of Glucagon Secretion

(2010) Sylvain J. Le Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in Na+ Conductance Density and Na+ Channel Functional Properties Between Dopamine and GABA Neurons of the Rat Substantia Nigra

(2010) Vincent Seutin et al.   JOURNAL OF NEUROPHYSIOLOGY

A Simplified Approach to Human Islet Quality Assessment

(2010) Matthew S. Hanson et al.   TRANSPLANTATION

Islet architecture: A comparative study

(2010) Abraham Kim et al.   Islets

Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system

(2009) Christian Giaume et al.   BRAIN RESEARCH REVIEWS

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

The  -Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing

(2009) D. A. Jacobson et al.   DIABETES

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells

(2009) M. Braun et al.   DIABETOLOGIA

Glucose Generates Coincident Insulin and Somatostatin Pulses and Antisynchronous Glucagon Pulses from Human Pancreatic Islets

(2009) Bo Hellman et al.   ENDOCRINOLOGY

Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: Animal and human studies

(2009) Grzegorz R. Juszczak et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Glucagon and hyperglycaemia in diabetes

(2008) Philip E. Cryer   CLINICAL SCIENCE

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

(2008) Véronique Serre-Beinier et al.   HUMAN MOLECULAR GENETICS

Cell coupling in mouse pancreatic  -cells measured in intact islets of Langerhans

(2008) Q. Zhang et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES