Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell

Aberrant islet unfolded protein response in type 2 diabetes

(2014) Feyza Engin et al.   Scientific Reports

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains

(2013) Emily K. Sims et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (CHOP) linked to type 2 diabetes

(2013) Chrysovalantou Mihailidou et al.   BIOCHIMIE

Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves  -Cell Mass and Function in ZDF Rats

(2013) J. Mahadevan et al.   DIABETES

Lost in translation: endoplasmic reticulum stress and the decline ofβ-cell health in diabetes mellitus

(2013) C. Evans-Molina et al.   DIABETES OBESITY & METABOLISM

Detection of Islet β-Cell Death in Vivo by Multiplex PCR Analysis of Differentially Methylated DNA

(2013) Marisa M. Fisher et al.   ENDOCRINOLOGY

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Imaging beta-cell mass and function in situ and in vivo

(2013) Lu Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Streptozotocin is equally diabetogenic whether administered to fed or fasted mice

(2013) Zunaira Z Chaudhry et al.   LABORATORY ANIMALS

Measuring protein interactions using Förster resonance energy transfer and fluorescence lifetime imaging microscopy

(2013) Richard N. Day   METHODS

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Distinct Roles of the C-terminal 11th Transmembrane Helix and Luminal Extension in the Partial Reactions Determining the High Ca2+Affinity of Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2b (SERCA2b)

(2012) Johannes D. Clausen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR-γ Activation Restores Pancreatic Islet SERCA2 Levels and Prevents β-Cell Dysfunction under Conditions of Hyperglycemic and Cytokine Stress

(2012) Tatsuyoshi Kono et al.   MOLECULAR ENDOCRINOLOGY

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

(2012) Sonya G. Fonseca et al.   NATURE CELL BIOLOGY

The Evolutionary History of Sarco(endo)plasmic Calcium ATPase (SERCA)

(2012) Ianina Altshuler et al.   PLoS One

What lies ahead for the proprotein convertases?

(2011) Nabil G. Seidah   Annals of the New York Academy of Sciences

The central role of calcium in the effects of cytokines on beta-cell function: Implications for type 1 and type 2 diabetes

(2011) James W. Ramadan et al.   CELL CALCIUM

Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic  -Cells: Interplay With Cell Metabolism and [Ca2+]c and Role of SERCA2b and SERCA3

(2011) M. A. Ravier et al.   DIABETES

Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic  -cells

(2011) M. Hatanaka et al.   HUMAN MOLECULAR GENETICS

Neutralizing Interleukin-1β (IL-1β) Induces β-Cell Survival by Maintaining PDX1 Protein Nuclear Localization

(2011) Amin Ardestani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic reticulum stress, obesity and diabetes

(2011) Miriam Cnop et al.   TRENDS IN MOLECULAR MEDICINE

The Ca2+ Pumps of the Endoplasmic Reticulum and Golgi Apparatus

(2011) I. Vandecaetsbeek et al.   Cold Spring Harbor Perspectives in Biology

Activation and regulation of store-operated calcium entry

(2010) Jeremy T. Smyth et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

(2010) Jeffrey M. Sturek et al.   JOURNAL OF CLINICAL INVESTIGATION

Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity

(2010) S. W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

MODY7Gene,KLF11, Is a Novel p300-dependent Regulator ofPdx-1(MODY4) Transcription in Pancreatic Islet β Cells

(2009) Martin E. Fernandez-Zapico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling

(2009) Takeshi Ogihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-Activated Receptor   Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure

(2009) C. Evans-Molina et al.   MOLECULAR AND CELLULAR BIOLOGY

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes

(2008) J.-F. Gautier et al.   DIABETES & METABOLISM

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS