Negative regulation of type I IFN signaling

ISG'ylation increases stability of numerous proteins including Stat1, which prevents premature termination of immune response in LPS-stimulated microglia

(2018) Piotr Przanowski et al.   NEUROCHEMISTRY INTERNATIONAL

MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE

(2017) Siobhán Smith et al.   JOURNAL OF AUTOIMMUNITY

The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation

(2017) Xue Jia et al.   JOURNAL OF IMMUNOLOGY

Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization

(2017) Jae-Hoon Kim et al.   JOURNAL OF VIROLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300

(2017) Shengyu Wang et al.   Frontiers in Cellular and Infection Microbiology

MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses

(2017) Chanyoung Shin et al.   Scientific Reports

TC-PTP and PTP1B: Regulating JAK–STAT signaling, controlling lymphoid malignancies

(2016) Kelly A. Pike et al.   CYTOKINE

Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387

(2016) Yuxin Wang et al.   EMBO JOURNAL

Response to interferons and antibacterial innate immunity in the absence of tyrosine‐phosphorylated STAT1

(2016) Andrea Majoros et al.   EMBO REPORTS

Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response

(2016) Håkan C. Steen et al.   JOURNAL OF CELL SCIENCE

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS

(2016) Lin-Gao Ju et al.   JOURNAL OF IMMUNOLOGY

A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation

(2016) Di Peng et al.   JOURNAL OF IMMUNOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling

(2016) Abigail Jarret et al.   NATURE MEDICINE

S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification

(2016) John R. Teijaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation

(2016) Wendie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS)

(2016) Shengfeng Wan et al.   Oncotarget

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

(2016) Johnathan Ho et al.   PLOS BIOLOGY

Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

(2016) Sajith Nair et al.   Scientific Reports

Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

(2015) Qingliang Zheng et al.   CELL RESEARCH

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

ATF3 Is a Key Regulator of Macrophage IFN Responses

(2015) Larisa I. Labzin et al.   JOURNAL OF IMMUNOLOGY

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms

(2015) Ming-Ming Hu et al.   JOURNAL OF IMMUNOLOGY

SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity

(2015) Dong Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation

(2015) Jun-Bao Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6

(2015) Dandan Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling

(2015) Young-Suk Yoo et al.   Nature Communications

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

(2015) Peng Wang et al.   PLoS Pathogens

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription

(2014) Jing Ouyang et al.   Cell Host & Microbe

NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection

(2014) Priya Ranjan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

(2014) Yihui Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Smurf2 Negatively Modulates RIG-I-Dependent Antiviral Response by Targeting VISA/MAVS for Ubiquitination and Degradation

(2014) Y. Pan et al.   JOURNAL OF IMMUNOLOGY

Soluble IFN Receptor Potentiates In Vivo Type I IFN Signaling and Exacerbates TLR4-Mediated Septic Shock

(2014) S. A. Samarajiwa et al.   JOURNAL OF IMMUNOLOGY

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways

(2014) Jun Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production

(2014) K. Narayan et al.   JOURNAL OF VIROLOGY

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Negative regulation of the interferon response by an interferon-induced long non-coding RNA

(2014) Hiroto Kambara et al.   NUCLEIC ACIDS RESEARCH

The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25

(2014) E.-K. Pauli et al.   Science Signaling

Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon

(2014) Bing-Ching Ho et al.   Nature Communications

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

(2013) Jun Cui et al.   CELL RESEARCH

Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10

(2013) Christoph Burkart et al.   EMBO Molecular Medicine

Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7

(2013) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Enhancer of Zeste Homolog 2 Is a Negative Regulator of Mitochondria-Mediated Innate Immune Responses

(2013) S. Chen et al.   JOURNAL OF IMMUNOLOGY

Interferon-Inducible Protein IFI35 Negatively Regulates RIG-I Antiviral Signaling and Supports Vesicular Stomatitis Virus Replication

(2013) A. Das et al.   JOURNAL OF VIROLOGY

MicroRNA Profiling of Sendai Virus-Infected A549 Cells Identifies miR-203 as an Interferon-Inducible Regulator of IFIT1/ISG56

(2013) W. A. Buggele et al.   JOURNAL OF VIROLOGY

OASL1 inhibits translation of the type I interferon–regulating transcription factor IRF7

(2013) Myeong Sup Lee et al.   NATURE IMMUNOLOGY

TRIM11 Negatively Regulates IFNβ Production and Antiviral Activity by Targeting TBK1

(2013) Younglang Lee et al.   PLoS One

Ubiquitin-Specific Proteases 25 Negatively Regulates Virus-Induced Type I Interferon Signaling

(2013) Huijuan Zhong et al.   PLoS One

DDX24 Negatively Regulates Cytosolic RNA-Mediated Innate Immune Signaling

(2013) Zhe Ma et al.   PLoS Pathogens

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice

(2012) Yanzheng Tong et al.   CELL RESEARCH

MicroRNA-466l inhibits antiviral innate immune response by targeting interferon-alpha

(2012) Yingke Li et al.   Cellular & Molecular Immunology

Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways

(2012) Y. Sugiyama et al.   INTERNATIONAL IMMUNOLOGY

Sprouty Proteins Are Negative Regulators of Interferon (IFN) Signaling and IFN-inducible Biological Responses

(2012) Bhumika Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of STAT2 Serine 287 as a Novel Regulatory Phosphorylation Site in Type I Interferon-induced Cellular Responses

(2012) Håkan C. Steen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smurf1 Protein Negatively Regulates Interferon-γ Signaling through Promoting STAT1 Protein Ubiquitination and Degradation

(2012) Chao Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

(2012) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

TRIM38 Negatively Regulates TLR3-Mediated IFN-β Signaling by Targeting TRIF for Degradation

(2012) Qinghua Xue et al.   PLoS One

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration

(2011) Ning Xiao et al.   BIOCHEMICAL JOURNAL

Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)

(2011) Xiang Zhou et al.   CELL RESEARCH

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Innate and adaptive immune responses to cell death

(2011) Kenneth L. Rock et al.   IMMUNOLOGICAL REVIEWS

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

(2011) Rebecca A. R. Piganis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Phosphorylation of Protein Kinase D2 Mediates Ligand-inducible Elimination of the Type 1 Interferon Receptor

(2011) Hui Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7

(2011) Q. Liang et al.   JOURNAL OF IMMUNOLOGY

Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7

(2011) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

ISG56 and IFITM1 Proteins Inhibit Hepatitis C Virus Replication

(2011) A. Raychoudhuri et al.   JOURNAL OF VIROLOGY

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

(2011) Aikaterini S Papadopoulou et al.   NATURE IMMUNOLOGY

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor

(2011) Stuart T. Perry et al.   PLoS Pathogens

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

(2010) Yanxing Yu et al.   IMMUNITY

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA Regulation of IFN-β Protein Expression: Rapid and Sensitive Modulation of the Innate Immune Response

(2010) Kenneth W. Witwer et al.   JOURNAL OF IMMUNOLOGY

Negative Regulation of IRF7 Activation by Activating Transcription Factor 4 Suggests a Cross-Regulation between the IFN Responses and the Cellular Integrated Stress Responses

(2010) Q. Liang et al.   JOURNAL OF IMMUNOLOGY

Ligand-Stimulated Downregulation of the Alpha Interferon Receptor: Role of Protein Kinase D2

(2010) H. Zheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

(2009) Yuanjia Tang et al.   ARTHRITIS AND RHEUMATISM

IFR-9/STAT2 Functional Interaction Drives Retinoic Acid-Induced Gene G Expression Independently of STAT1

(2009) Y.-J. Lou et al.   CANCER RESEARCH

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

(2009) M. Sarasin-Filipowicz et al.   MOLECULAR AND CELLULAR BIOLOGY

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway

(2009) Eva M Palsson-McDermott et al.   NATURE IMMUNOLOGY

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

(2009) H. Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

(2009) Peyman Nakhaei et al.   PLoS Pathogens

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

(2008) Min Zhang et al.   CELL RESEARCH

Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1

(2008) Fulvia Terenzi et al.   EMBO JOURNAL

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

Type I interferons as vaccine adjuvants against infectious diseases and cancer

(2008) Laura Bracci et al.   Expert Review of Vaccines

Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

(2008) C. Lai et al.   JOURNAL OF VIROLOGY

Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages

(2008) Hongmei Xu et al.   MOLECULAR IMMUNOLOGY

TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation

(2008) Mude Shi et al.   NATURE IMMUNOLOGY

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY