Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10

Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15

(2012) Young Joo Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

Usp18 Promotes Conventional CD11b+ Dendritic Cell Development

(2012) X.-L. Cong et al.   JOURNAL OF IMMUNOLOGY

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

(2011) Ourania Koltsida et al.   EMBO Molecular Medicine

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Two Independent Mechanisms Promote Expression of an N-terminal Truncated USP18 Isoform with Higher DeISGylation Activity in the Nucleus

(2011) Christoph Burkart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

(2011) Ole Audun Werner Haabeth et al.   Nature Communications

CD4+ T cells inhibit the neu-specific CD8+ T-cell exhaustion during the priming phase of immune responses against breast cancer

(2010) Maciej Kmieciak et al.   BREAST CANCER RESEARCH AND TREATMENT

Integrating individual functional moieties of CXCL10 and CXCL11 into a novel chimeric chemokine leads to synergistic antitumor effects: a strategy for chemokine-based multi-target-directed cancer therapy

(2010) Ping Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Blockade of the Ubiquitin Protease UBP43 Destabilizes Transcription Factor PML/RAR  and Inhibits the Growth of Acute Promyelocytic Leukemia

(2010) Y. Guo et al.   CANCER RESEARCH

Identification of USP18 as an Important Regulator of the Susceptibility to IFN-  and Drug-Induced Apoptosis

(2010) H. Potu et al.   CANCER RESEARCH

Interferon Lambda as a Potential New Therapeutic for Hepatitis C

(2009) Dennis M. Miller et al.   Annals of the New York Academy of Sciences

Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory

(2009) W. Jing et al.   BLOOD

Induction of IP-10/CXCL10 secretion as an immunomodulatory effect of low-dose adjuvant interferon-alpha during treatment of melanoma☆

(2009) Anne-Marie Mohty et al.   IMMUNOBIOLOGY

Impaired interferon signaling is a common immune defect in human cancer

(2009) R. J. Critchley-Thorne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFR1 Signaling and IFN-γ Signaling Determine whether T Cells Induce Tumor Dormancy or Promote Multistage Carcinogenesis

(2008) Nele Müller-Hermelink et al.   CANCER CELL

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens