Journal
MOLECULAR IMMUNOLOGY
Volume 78, Issue -, Pages 57-64Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2016.08.008
Keywords
ASF1a; CBP; H3K56; IFN-beta
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ASF1a (anti-silencing function 1a), an evolutionarily conserved protein and a histone chaperone, is required for a variety of chromatin-mediated cellular processes. However, the function of ASF1a in innate immune response remains unclear. Here, we find that ASF1a is induced in Vesicular Stomatitis Virus (VSV)-infected macrophages in a manner that is dependent on IRF3 signal. ASF1a promotes VSV-triggered IFN-beta production, Moreover, acetylation of H3K56 increases at the ifnb promoter after VSV infection, which is dependent on ASFI a. Furthermore, we find ASF1a-mediated H3K56ac is dependent on the acetyltransferases activity of CREB binding protein (CBP) and the association between ASFI a and CBP. Therefore, our work provides a new insight into the antiviral mechanism that histone chaperone ASF1a-mediated H3K56ac modification promotes IFN-beta production. (C) 2016 Elsevier Ltd. All rights reserved.
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