miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin

Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis

(2017) Wenyu Fu et al.   FASEB JOURNAL

Progranulin Protects Against Osteonecrosis of the Femoral Head by Activating ERK1/2 Pathway

(2017) Yingguang Han et al.   INFLAMMATION

MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN

(2017) Lingqiang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Contribution of Progranulin to Protective Lung Immunity During Bacterial Pneumonia

(2017) Shan Zou et al.   JOURNAL OF INFECTIOUS DISEASES

Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury

(2017) J. B. Kral-Pointner et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Chemokine Involvement in Lung Injury Secondary to Ischaemia/Reperfusion

(2017) Lisa Rancan et al.   LUNG

Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

(2017) Grietje Krabbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as Potential Biomarkers of Infectious Disease

(2017) Carolina N. Correia et al.   Frontiers in Immunology

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy

(2016) Jianhua Chen et al.   ACS Nano

Progranulin Plays a Central Role in Host Defense during Sepsis by Promoting Macrophage Recruitment

(2016) Zhixin Song et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice

(2016) Angara Sureshbabu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling

(2016) Guangzhi Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling

(2016) Zhi-feng Liu et al.   APOPTOSIS

MicroRNA-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures

(2016) Liqun Liu et al.   BMC NEUROSCIENCE

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension

(2016) Aurélien Parpaleix et al.   EUROPEAN RESPIRATORY JOURNAL

EphA2 is a functional receptor for the growth factor progranulin

(2016) Thomas Neill et al.   JOURNAL OF CELL BIOLOGY

Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock

(2016) Yuan Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synthetic Amphipathic Helical Peptides Targeting CD36 Attenuate Lipopolysaccharide-Induced Inflammation and Acute Lung Injury

(2016) Alexander V. Bocharov et al.   JOURNAL OF IMMUNOLOGY

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2016) Qin Wang et al.   MEDIATORS OF INFLAMMATION

MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma

(2016) Li Qian et al.   Molecular Medicine Reports

Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress

(2016) Yanbo Ma et al.   MOLECULAR NEUROBIOLOGY

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice

(2016) Jeong-Ran Park et al.   Oncotarget

Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling

(2016) Feng Liu et al.   Scientific Reports

Changes in the Expression of miR-34a and its Target Genes Following Spinal Cord Injury In Rats

(2016) Ying Chen et al.   MEDICAL SCIENCE MONITOR

Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury

(2016) Chad A. Lerner et al.   Frontiers in Pharmacology

Tissue-Specific Expression Patterns of MicroRNA during Acute Graft-versus-Host Disease in the Rat

(2016) Dasaradha Jalapothu et al.   Frontiers in Immunology

MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4

(2016) Juanjuan Zhao et al.   Frontiers in Immunology

Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment

(2015) Ruan Cox et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes

(2015) Lin Xu et al.   DISEASE MARKERS

Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment

(2015) Chenhui Zhou et al.   Journal of Neuroinflammation

Progranulin protects against renal ischemia/reperfusion injury in mice

(2015) Meng Zhou et al.   KIDNEY INTERNATIONAL

Nogo-B protects mice against lipopolysaccharide-induced acute lung injury

(2015) Wujian Xu et al.   Scientific Reports

Complement C5a exacerbates acute lung injury induced through autophagy-mediated alveolar macrophage apoptosis

(2014) R Hu et al.   Cell Death & Disease

Lung Natural Killer Cells Play a Major Counter-Regulatory Role in Pulmonary Vascular Hyperpermeability After Myocardial Infarction

(2013) Xiaoxiang Yan et al.   CIRCULATION RESEARCH

MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met

(2013) LI-GUANG WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNAs are dynamically regulated and play an important role in LPS-induced lung injury

(2012) Zhi-Gang Cai et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Interactions ofmiR-34b/candTP53Polymorphisms on the Risk of Intracranial Aneurysm

(2012) Lijuan Li et al.   Clinical & Developmental Immunology

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin

(2012) Zhongliang Guo et al.   MEDIATORS OF INFLAMMATION

Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice

(2011) Jian Wang et al.   CELL RESEARCH

Epidemiology of ARDS and ALI

(2011) Ross Blank et al.   CRITICAL CARE CLINICS

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer

(2011) Norimitsu Tanaka et al.   LUNG CANCER

p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

(2011) N. H. Kim et al.   Science Signaling

Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage

(2011) Sabina Halappanavar et al.   TOXICOLOGY

miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease

(2010) Wang-Xia Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

(2010) N. Finch et al.   NEUROLOGY

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia

(2010) Jian Jiao et al.   PLoS One

Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke

(2008) Alberto Izzotti et al.   FASEB JOURNAL

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

(2008) Rosa Rademakers et al.   HUMAN MOLECULAR GENETICS