Article
Biology
Thomas Greither, Tina Steiner, Matthias Bache, Ginette Serrero, Sven Otto, Helge Taubert, Alexander W. Eckert, Matthias Kappler
Summary: The study suggests that increased levels of GP88 in the serum of oral squamous cell carcinoma (OSCC) patients are associated with a better prognosis, and may serve as an independent predictor of OSCC patients' outcomes. Low serum GP88 levels are significantly linked to a worsened prognosis for OSCC, especially in patients over the age of 60.5.
Article
Immunology
Sharad Purohit, Paul Minh Huy Tran, Lynn Kim Hoang Tran, Khaled Bin Satter, Mingfang He, Wenbo Zhi, Shan Bai, Diane Hopkins, Melissa Gardiner, Chandramohan Wakade, Jennifer Bryant, Risa Bernard, John Morgan, Bruce Bode, John Chip Reed, Jin-Xiong She
Summary: Chronic low-grade inflammation is involved in the pathogenesis of type-1 diabetes (T1D) and its complications. Elevated serum levels of soluble cytokine receptors were found to be significantly associated with the presence of diabetic peripheral neuropathy (DPN) in T1D patients, independent of gender, age and duration of diabetes. The study also identified specific cytokine receptors that were associated with increased risk of DPN, suggesting potential for these markers to be used as a clinical tool for therapeutic intervention in T1D patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Xuerui Wu, Cynthia Kwan Yui Cheung, Dewei Ye, Subrata Chakrabarti, Hema Mahajan, Sen Yan, Erfei Song, Wah Yang, Chi Ho Lee, Karen Siu Ling Lam, Cunchuan Wang, Aimin Xu
Summary: The study found that serum thrombospondin-2 (TSP2) is closely associated with the severity and progression of obesity-related metabolic syndrome (MetS) and metabolic associated fatty liver disease (MAFLD). Serum TSP2 is a promising noninvasive biomarker for differentiating metabolic associated steatohepatitis (MASH) and identifying at-risk patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Filippo Luca Gurgoglione, Dario Pitocco, Rocco A. Montone, Riccardo Rinaldi, Riccardo C. Bonadonna, Giulia Magnani, Camilla Calvieri, Emilia Solinas, Alessandro Rizzi, Linda Tartaglione, Andrea Flex, Luca Viti, Carlo Trani, Diego Ardissino, Filippo Crea, Giampaolo Niccoli
Summary: The study aimed to investigate the influence of diabetic microvascular complications (DMC) on coronary collateral (CC) vessel development in patients with coronary chronic total occlusion (CTO). Results showed that patients with DMC had a higher prevalence of CC and high-grade CC compared with those without DMC. Furthermore, there was a positive association between the number of DMC in each patient and the prevalence of high-grade CC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Po-hung Wu, Gabby Joseph, Isra Saeed, Amir M. Pirmoazen, Katie Kenny, Tiffany Y. Kim, Anne L. Schafer, Ann V. Schwartz, Xiaojuan Li, Thomas M. Link, Galateia J. Kazakia
Summary: This study found associations between marrow adiposity and composition with lipid levels and T2D status, which were sex-specific. LDL cholesterol was positively associated with marrow fat in male T2D patients, while HDL was negatively associated with marrow fat in female T2D patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jun-Wei Wang, Chun-Hua Jin, Jiang-Feng Ke, Yi-Lin Ma, Yu-Jie Wang, Jun-Xi Lu, Mei-Fang Li, Lian-Xi Li
Summary: This study found a positive correlation between serum iron levels and the presence of MAFLD in T2DM patients, possibly due to the close association between serum iron and insulin resistance. Serum iron levels may serve as an indicator for assessing the risk of MAFLD in individuals with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Sijia Zhang, Yan Zong, Yue Hu, Yuhan Sheng, Guangqin Xiao
Summary: Among HBsAg-positive adults, highly elevated levels of serum HBV-DNA are independently associated with an increased risk of type 2 diabetes, while moderately to slightly raised levels are not associated with diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Cheng Wang, Yunhua Zhu, Penglu Chen, Chen Wang, Wanqing Zhou, Cuiping Zhang, Jing Wang, Xi Chen, Meng Ding, Chunni Zhang, Jun-Jun Wang, Chen-Yu Zhang
Summary: The majority of HCMV miRNAs were significantly upregulated in the serum of fever patients, suggesting their potential role in monitoring HCMV activation status in patients with immune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiahao Zhu, Lingling Sun, Jing Yang, Jiayao Fan, Lap Ah Tse, Yingjun Li
Summary: The study found significant associations between T2D and fasting insulin levels with increased serum urate concentrations, suggesting a potential link between fasting insulin and risk of gout. However, genetic predisposition to urate and gout did not show associations with T2D or any of the 4 glycemic traits investigated. Further research is needed to explore the underlying biological mechanisms of these relationships.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Wei-Jing Zhao, Xin-Yi Xia, Jun Yin
Summary: The study found that vitamin D deficiency is independently associated with a higher risk of DPN and DN in T2DM patients, but not DR. Additionally, vitamin D deficiency may serve as a potential predictor for both the occurrence and severity of DPN and DN.
CHINESE MEDICAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Lynette J. Oost, Amber A. W. A. van der Heijden, Emma A. Vermeulen, Caro Bos, Petra J. M. Elders, Roderick C. Slieker, Steef Kurstjens, Miranda van Berkel, Joost G. J. Hoenderop, Cees J. Tack, Joline W. J. Beulens, Jeroen H. F. de Baaij
Summary: The study found that serum magnesium (Mg2+) concentration is inversely associated with the development of heart failure (HF) and atrial fibrillation (AF) as well as the occurrence of chronic kidney disease (CKD), diabetic retinopathy, and diabetic foot complications in type 2 diabetes patients. Additionally, glycemic control, as measured by hemoglobin A(1c) [HbA(1c)], partially mediated the association between serum Mg2+ and HF and microvascular complications.
Article
Medicine, General & Internal
Shaik Sarfaraz Nawaz, Khalid Siddiqui, Muhammad Mujammami, Obeed Alotaibi, Saud Sulaiman Alanazi, Mohamed Rafiullah
Summary: This study investigated the role of osteopontin (OPN) in type 2 diabetes (T2D) patients with microvascular complications. The results showed a strong correlation between OPN levels and C-reactive protein, suggesting its potential as a marker for predicting vascular disease.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Neurosciences
Hui Han, Feng Wang, Juanjuan Chen, Xingxing Li, Gaoqing Fu, Jiawei Zhou, Dongsheng Zhou, Wei Wu, Haimin Chen
Summary: Changes in Hcy, Cys, and GSH levels in the brain of APP/PS1 mice and A beta(1-42)-treated PC12 cells were observed in situ with a new fluorescent probe, which were consistent with the abnormal changes in Hcy, Cys, and GSH levels in the serum of AD patients. VB6 supplementation was successful in ameliorating abnormal increases in Hcy levels.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Urology & Nephrology
Zhicai Feng, Xiangyu Liao, Hao Zhang, Juan Peng, Zhijun Huang, Bin Yi
Summary: The study investigates the association between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and renal function impairment in type 2 diabetes mellitus (T2DM) patients. The results show that PCSK9 levels are positively correlated with UACR and inversely correlated with eGFR in T2DM patients. Additionally, PCSK9 levels are also associated with various clinical indicators of renal function impairment.
Article
Medical Laboratory Technology
Lu Peng, Xinwei Li, Yu Li, Wen Zhao, Shaoping Nie, Huahui Yu, Yue Qi, Yanwen Qin, Huina Zhang
Summary: The study found that the concentrations of serum EV-derived MPO and serum MPO were significantly higher in T2DM patients compared with non-T2DM subjects. Multivariate logistic regression analysis showed that both serum EV-derived MPO and serum MPO were independently associated with the presence of T2DM even after adjusting for confounding factors.
CLINICA CHIMICA ACTA
(2021)
Article
Behavioral Sciences
Lou-Yan Ma, Song-Fang Liu, Jun-Hui Du, Yu Niu, Peng-Fei Hou, Qing Shu, Ran-Ran Ma, Song-Di Wu, Qiu-Min Qu, Ya-Li Lv
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Article
Immunology
Bo Zhou, Jianqing She, Yadan Wang, Xiancang Ma
CLINICAL INFECTIOUS DISEASES
(2020)
Letter
Infectious Diseases
Bo Zhou, Jianqing She, Yadan Wang, Xiancang Ma
JOURNAL OF INFECTION
(2020)
Article
Cardiac & Cardiovascular Systems
Bo Zhou, Jianqing She, Yadan Wang, Xiancang Ma
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2020)
Article
Biochemistry & Molecular Biology
Bo Zhou, Yulong Xia, Jianqing She
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Guomin Yao, Rong Li, Junhui Du, Yang Yao
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2020)
Article
Medicine, Research & Experimental
Dongjun Chen, Yi Wang, Mengyi Liu, Jing Cheng, Zhe Liu, Yang Song, Junhui Du
Summary: This study demonstrated that Visfatin promotes the proliferation, migration, and tube formation of RF/6A cells under high glucose conditions, indicating a potent effect of Visfatin on retinal neovascularization.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Ophthalmology
Qian Zhang, Hong-Song Li, Rong Li, Jun-Hui Du, Cong Jiao
Summary: The study investigated the role and mechanism of autophagy in retinal pigment epithelial cells damaged by high glucose, revealing decreased cell viability, increased apoptosis, and activated autophagic flux under high glucose conditions. These changes were reversed by treatment with an autophagy inhibitor. New strategies for managing diabetic retinopathy may be developed based on autophagy regulation.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Peripheral Vascular Disease
Yi Wang, Yang Yao, Rong Li, Binghui Wu, Huiqin Lu, Jing Cheng, Zhe Liu, Junhui Du
Summary: The study found that the anti-VEGF drugs Ranibizumab and Conbercept may trigger autophagy in vascular endothelial cells, while Aflibercept may inhibit autophagy. The combination of Conbercept and autophagy inhibitors can significantly inhibit angiogenesis in vitro. The mechanism of autophagy activation is related to the activation of the p53/DRAM pathway.
MICROVASCULAR RESEARCH
(2021)
Article
Ophthalmology
Le Zhang, Rong Li, Bing-Hui Wu, Ting-Ting Liang, Zhe Liu, Wei Ju, Yi Wang, Yu-Ting Wen, Ming-Cui Liu, Jun-Hui Du
Summary: The study showed that Leptin promotes proliferation, migration, and tube formation of RF/6A cells in a dose-dependent manner, and this effect is mediated through activation of the JAK2/STAT3 signaling pathway.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lin Run, Zhufang Tian, Lin Xu, Junhui Du, Nan Li, Qi Wang, Hongzhi Sun
Summary: Insulin resistance (IR) plays a significant role in the development of Type 2 diabetes mellitus (T2DM), and inflammation is closely related to IR and T2DM. This study investigated the role of Interleukin-4-induced gene 1 (IL4I1) in T2DM. The results showed that IL4I1 expression was up-regulated in peripheral blood samples of T2DM patients and high glucose-treated HepG2 cells, and silencing IL4I1 reduced inflammation, improved lipid metabolism, and attenuated IR in these cells by inhibiting the aryl hydrocarbon receptor (AHR) signaling pathway. This suggests that IL4I1 could be a potential therapeutic target for T2DM.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Energy & Fuels
Yanxia Zhou, Zhiwei Jiang, Hui Pu, Yahui Ding, Junhui Du, Yufeng Wang, Yunfei Shan
Summary: Nanoparticles have been successfully used in enhancing oil recovery (EOR) due to their small size and abundant surface functional groups. In this research, SiO2 nanoparticles of different sizes were synthesized and their properties in terms of interfacial tension, contact angle, viscosity, capillary pressure, and oil extraction ability were investigated. The results showed that SiO2 nanoparticles with a size of about 60nm were the most efficient oil-displacing agent for medium-permeability reservoirs.
Article
Oncology
Yuting Wen, Yi Wang, Yao Huang, Zhe Liu, Chan Hui
Summary: This study investigated the expression of PLVAP in stomach adenocarcinoma (STAD) patients and its value in predicting patient prognosis. The results showed that elevated PLVAP expression was associated with advanced disease and worse clinical outcomes. Furthermore, PLVAP expression was also found to be correlated with specific bacterial infections.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Energy & Fuels
Yanxia Zhou, Zhiwei Jiang, Hui Pu, Yahui Ding, Junhui Du, Yufeng Wang, Yunfei Shan
Summary: Nanoparticles have been successfully applied in enhanced oil recovery due to their small size and surface functional groups. However, the effect of nanoparticle size on oil recovery has not been systematically studied. In this research, SiO2 nanoparticles of different sizes were synthesized and their properties were investigated. The experimental results showed that as the SiO2 nanoparticle size decreased, there was a slight increase in interfacial tension, oil contact angle, viscosity, and capillary pressure. Among all the sizes, the 60 nm SiO2 nanoparticle-based nanofluid showed the highest efficiency in recovering oil.
Proceedings Paper
Automation & Control Systems
Junhui Du
Summary: By utilizing Struts 2 and Spring framework, along with Red5 streaming media server, a mobile learning platform for modern Chinese history was developed. Following J2EE principles, the system architecture and application design were completed, with each module coded according to layered architecture design idea. The platform demonstrates a good interface and real-time video synchronous transmission ability after practical deployment and testing.
2021 13TH INTERNATIONAL CONFERENCE ON MEASURING TECHNOLOGY AND MECHATRONICS AUTOMATION (ICMTMA 2021)
(2021)
