Article
Microbiology
Nikki Bortell, Elizabeth R. Aguilera, Laurel L. Lenz
Summary: Pulmonary coinfections can impair the host's ability to control systemic Lm, increasing susceptibility to severe infection. Exposure to microbial products can render hosts more susceptible to severe infection through an increase in IL-10 production. This increase in susceptibility correlates with a dampening of myeloid cell function in infected tissues.
Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Israel Martinez-Espinosa, Jose A. Serrato, Blanca Ortiz-Quintero
Summary: NK cells have the ability to produce both pro-inflammatory and anti-inflammatory cytokines, playing a crucial role in regulating inflammation during systemic infection. Understanding the factors driving the production of IL-10 by NK cells and its impact is important for therapeutic advancements in diseases like sepsis.
Article
Immunology
Lele Feng, Ruofei Tian, Xingdou Mu, Cheng Chen, Yuxi Zhang, Jun Cui, Yujie Song, Yingying Liu, Miao Zhang, Lei Shi, Yang Sun, Ling Li, Wei Yi
Summary: In this study, the distinct patterns of NK cell infiltration and apoptosis during the progression of acute myocardial infarction and ischemic stroke were explored. It was found that NK cell abundance correlated positively with apoptosis in both diseases, and several apoptosis-related genes showed negative correlation with NK cell abundance. These findings provide novel insights into the mechanisms underlying the patterns of NK cell abundance and apoptosis in acute myocardial infarction and ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Seung Hee Choi, Hye Jin Kim, Joo Dong Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Jin-Ho Choi, Hye Jung Jang, Isaac Kim, Hae-Yun Jung, Keun-Hong Park, Kyung-Soon Park
Summary: The chemical priming of NK cells using 25KbPEI enhances their antitumor activity and migration ability, offering a simple and cost-effective method for producing therapeutic NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Marko Kumric, Hrvoje Urlic, Admira Bilalic, Nikolina Rezic-Muzinic, Angela Mastelic, Anita Markotic, Doris Rusic, Josip A. Borovac, Darko Duplancic, Marina Luetic, Ivan Covic, Tina Ticinovic Kurir, Josko Bozic
Summary: This study investigates the dynamic changes of DNAM-1-expressing monocytes and NK cells in the peripheral blood during the early phase of reperfusion in patients with ST-elevation myocardial infarction (STEMI). The results show that the number of these cells is significantly reduced 3 hours after primary percutaneous coronary intervention (pPCI) and then returns to initial levels 24 hours after the procedure. Additionally, there is a correlation between the number of CD16++DNAM-1+ monocytes and the extent of myocardial injury.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Marc Jonathan George, Nur Hayati Jasmin, Valerie Taylor Cummings, Angela Richard-Loendt, Francesca Launchbury, Kevin Woollard, Tabitha Turner-Stokes, Ana Isabel Garcia Diaz, Mark Lythgoe, Daniel James Stuckey, Aroon Dinesh Hingorani, Derek William Gilroy
Summary: Interleukin (IL)-6 is an emerging therapeutic target in myocardial infarction (MI), with the novel recombinant fusion protein sgp130Fc showing efficacy in exclusive trans-signaling blockade. In a rat model, sgp130Fc attenuated infiltration and preserved cardiac function, in contrast to anti-IL-6 antibodies that result in panantagonism.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jiacheng Bi, Xiaomeng Jin, Chaoyue Zheng, Chen Huang, Chao Zhong, Xiaohu Zheng, Zhigang Tian, Haoyu Sun
Summary: Natural killer (NK) cells play dual roles in tumor surveillance and CD8(+) T-cell response. The T-bet/Eomes-IFN-gamma axis in NK cells is essential for CD8(+) T cell-dependent tumor control, and T-bet-dependent NK cell effector functions are required for an optimal response to anti-PD-L1 immunotherapy. NK cell-expressed TIPE2 represents a checkpoint molecule for NK cell helper function, and its targeting might boost both the antitumor T cell response and T cell-based immunotherapy.
Article
Oncology
Mireia Bachiller, Lorena Perez-Amill, Anthony Matthew Battram, Sebastian Ciro Carne, Amer Najjar, Els Verhoeyen, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martin-Antonio
Summary: This study demonstrates the important immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. Combinatorial treatment based on CAR-T and CAR-NK cells or CB-NK and CAR-T cells showed that CB-NK required high doses for effectiveness, while a low number of CB-NK in the CAR-T product promoted early activation of CAR-T cells and enhanced anti-MM efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Pauline Rettman, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura Espana-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, Salim Khakoo
Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Hettwer, Julia Hinterdobler, Benedikt Miritsch, Marcus-Andre Deutsch, Xinghai Li, Carina Mauersberger, Aldo Moggio, Quinte Braster, Hermann Gram, Avril A. B. Robertson, Matthew A. Cooper, Olaf Gross, Markus Krane, Christian Weber, Wolfgang Koenig, Oliver Soehnlein, Nicholas H. Adamstein, Paul Ridker, Heribert Schunkert, Peter Libby, Thorsten Kessler, Hendrik B. Sager
Summary: This study investigates the mechanisms of IL-1 beta-targeted therapies and finds that anti-IL-1 beta treatment and NLRP3-inflammasome inhibition can reduce vascular inflammation and progression of atherosclerosis through decreased supply and uptake of inflammatory leucocytes in the blood.
CARDIOVASCULAR RESEARCH
(2022)
Article
Clinical Neurology
Leoni Rolfes, Tobias Ruck, Christina David, Stine Mencl, Stefanie Bock, Mariella Schmidt, Jan-Kolja Strecker, Steffen Pfeuffer, Andreas-Schulte Mecklenbeck, Catharina Gross, Michael Gliem, Jens Minnerup, Michael K. Schuhmann, Christoph Kleinschnitz, Sven G. Meuth
Summary: The study compared immune-cell frequencies, phenotype, and effector functions of NK cells in Rag1(-/-) and wildtype mice, finding that NK cells in Rag1(-/-) were comparable to those in wildtype mice. Rag1(-/-) mice treated with anti-NK1.1 antibody showed significantly smaller infarctions and improved behavioral scores. NRG mice supplemented with NK cells were more susceptible to tMCAO, developing similar infarctions and neurological deficits as Rag1(-/-) controls.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Environmental Sciences
Liangtao Zhao, Wenyuan Shi, Fangfang Hu, Xujun Song, Zhangjun Cheng, Jiahua Zhou
Summary: Oral ingestion of microplastics increases liver weight, alters the immune cell populations and inflammatory cytokine expression, especially affecting the infiltration of natural killer cells and macrophages. These effects are regulated via the NF-κB pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cardiac & Cardiovascular Systems
Tianxiao Liu, Zhaojie Meng, Jing Liu, Jie Li, Yuanyuan Zhang, Zhiyong Deng, Songyuan Luo, Minjie Wang, Qin Huang, Shuya Zhang, Pauline Fendt, Julie Devouassoux, Dazhu Li, Andrew Neil James McKenzie, Matthias Nahrendorf, Peter Libby, Junli Guo, Guo Ping Shi
Summary: This study revealed an indirect cardiac reparative role of ILC2 in post-MI hearts via the IL5, EOS, and DC mechanism.
CARDIOVASCULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Tsunehisa Yamamoto, Motoaki Sano
Summary: The heart requires fatty acids for its activity, and regulation of fatty acid metabolism has significant impacts on the structure and function of the heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Immunology
Laura Chiossone, Eric Vivier
Summary: This article discusses the approaches developed to harness the anti-tumor function of NK cells and suggests promising strategies to enhance cancer immunotherapies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Laurent Gauthier, Angela Virone-Oddos, Jochen Beninga, Benjamin Rossi, Celine Nicolazzi, Celine Amara, Audrey Blanchard-Alvarez, Nicolas Gourdin, Jacqueline Courta, Alexandra Basset, Magali Agnel, Franceline Guillot, Gwendoline Grondin, Helene Bonnevaux, Anne-Laure Bauchet, Ariane Morel, Yannis Morel, Marielle Chiron, Eric Vivier
Summary: Researchers have developed a novel natural killer cell engager (NKCE) that targets leukemia cells and has potent antitumor activity without toxicity, suggesting its potential for clinical development.
NATURE BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Miki Imura, Tsunehisa Yamamoto, Ken-Ichi Hiasa
Summary: This study investigated the incidence of pulmonary thromboembolism (PE) during hospitalization and found that the incidence varied depending on clinical department and surgery status. The onset of PE during hospitalization led to prolonged hospital stay and increased in-hospital mortality rates. Therefore, conducting proper risk assessment and implementing preventive measures before admission are crucial.
CARDIOLOGY AND THERAPY
(2023)
Article
Cell Biology
Noella Lopes, Justine Galluso, Bertrand Escaliere, Sabrina Carpentier, Yann M. Kerdiles, Eric Vivier
Summary: NK cells and ILC1 are distinct populations of lymphocytes in peripheral tissues. This study used single-cell RNA sequencing and CITE-seq to explore the heterogeneity of NK and ILC1 between tissues. The researchers identified gene expression patterns specific to different subsets and markers to distinguish ILC1 from NK cells. This data provides valuable insights into the origin, phenotype, and biology of NK and ILC1 cells.
CELL REPORTS MEDICINE
(2022)
Letter
Critical Care Medicine
Julien Carvelli, Eric Vivier
CRITICAL CARE MEDICINE
(2023)
Review
Immunology
Noella Lopes, Eric Vivier, Emilie Narni-Mancinelli
Summary: The article introduces the developmental trajectory and cytokine production profile of innate lymphoid cells (ILCs). It describes the subsets, effector functions, and development of NK cells and ILC1s, and discusses their role in cancer and the effects of the tumor microenvironment on their metabolism.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Chemistry, Analytical
Yuta Maeda, Hiroki Okawara, Tomonori Sawada, Daisuke Nakashima, Joji Nagahara, Haruki Fujitsuka, Kaito Ikeda, Sosuke Hoshino, Yusuke Kobari, Yoshinori Katsumata, Masaya Nakamura, Takeo Nagura
Summary: The relationship between the onset of sweating (OS) and sweat lactate threshold (sLT) assessed using a new sweat lactate sensor was investigated. The study found that the OS was poorly correlated with the sLT, particularly in the early perspiration (EP) group. However, the sLT was strongly correlated with the blood lactate threshold (bLT) in both the EP and regular perspiration (RP) groups. The sLT can be used as a noninvasive and continuous alternative to the bLT, independent of early OS, but a late OS may affect the accuracy of the sLT.
Article
Biology
Hanif J. Khameneh, Nicolas Fonta, Alessandro Zenobi, Charlene Niogret, Pedro Ventura, Concetta Guerra, Ivo Kwee, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Andrea Cavalli, Francesco Bertoni, Eric Vivier, Andreas Trumpp, Greta Guarda
Summary: This study reveals the importance of MYC in NK cells and its role in regulating translation and expansion, as well as anticancer immunity. Deficiency of MYC in NK cells results in reduced numbers and impaired cytotoxic functions of mature NK cells.
LIFE SCIENCE ALLIANCE
(2023)
Article
Medicine, General & Internal
Toshinobu Ryuzaki, Yasuyuki Shiraishi, Kotaro Miura, Hidehiko Ikura, Yuta Seki, Koichiro Azuma, Kazuki Sato, Keiichi Fukuda, Yoshinori Katsumata
Summary: This study aims to validate a method for estimating anaerobic threshold (AT) using heart rate variability (HRV) analysis from electrocardiography data in patients with heart failure. The study found a correlation between the HRV threshold and the VO2 at AT, suggesting that HRV may be a useful indicator for estimating AT in patients with heart failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Eve Playoust, Romain Remark, Eric Vivier, Pierre Milpied
Summary: B cells are crucial for immunity and are involved in affinity maturation and differentiation through B-cell receptor signals and signals from the microenvironment. They have been discovered to play important roles in antitumor responses in human cancers, but their dynamics and interplay are not well understood. B-cell responses involve both GC-dependent and GC-independent pathways, with affinity maturation occurring in GC reactions. Reactivation of high-affinity Bmem cells leads to the production of large numbers of PCs without BCR rediversification. Multiple tools and techniques are needed to understand B-cell dynamics in immune responses. Studying TIL-B cells and TIL-PC in solid tumors can provide insights for antitumor therapies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Tsunehisa Yamamoto, Santosh K. Maurya, Elizabeth Pruzinsky, Kirill Batmanov, Yang Xiao, Sarah M. Sulon, Tomoya Sakamoto, Yang Wang, Ling Lai, Kendra S. McDaid, Swapnil V. Shewale, Teresa C. Leone, Timothy R. Koves, Deborah M. Muoio, Pieterjan Dierickx, Mitchell A. Lazar, E. Douglas Lewandowski, Daniel P. Kelly
Summary: During the development of heart failure, the capacity for cardiomyocyte fatty acid oxidation and ATP production is diminished, leading to pathological cardiac hypertrophy and contractile dysfunction. The deficiency of receptor-interacting protein 140 (RIP140) results in increased expression of genes involved in mitochondrial energy metabolism and contractile function, providing protection against cardiac hypertrophy and heart failure. The loss of RIP140 in heart enhances fatty acid utilization and triacylglyceride turnover, suggesting a potential therapeutic target for the treatment of heart failure.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Meeting Abstract
Oncology
Laurent Greillier, Florence Monville, Vanina Leca, Frederic Vely, Stephane Garcia, Joseph Ciccolini, Florence Sabatier, Gilbert Ferrani, Nawel Boudai, Lamia Ghezali, Marcellin Landri, Clemence Marin, Mourad Hamimed, Laurent Arnaud, Melanie Karlsen, Kevin Atsou, Sivan Bokobza, Pauline Fleury, Arnaud Boyer, Clarisse Audigier-Valette, Stephanie Martinez, Herve Pegliasco, Patrice Ray, Lionel Falchero, Antoine Serre, Nicolas Cloarec, Louisiane Lebas, Stephane Hominal, Patricia Barre, Sarah Zahi, Ahmed Frikha, Pierre Bory, Maryannick Le Ray, Lilian Laborde, Virginie Martin, Richard Malkoun, Marie Roumieux, Julien Mazieres, Maurice Perol, Eric Vivier, Sebastien Benzekry, Jacques Fieschi, Fabrice Barlesi
Meeting Abstract
Hematology
Alexandre Tang, Laurent Gauthier, Jochen Beninga, Benjamin Rossi, Nicolas Gourdin, Audrey Blanchard-Alvarez, Celine Amara, Jacqueline Courta, Alexandra Basset, Dorothee Bourges, Alexandre Desjonqueres, Emmanuelle Menoret, Catherine Pellat-Deceunynck, Philippe Moreau, Yannis Morel, Marielle Chiron, Angela Virone-Oddos, Eric Vivier
Meeting Abstract
Hematology
Olivier Demaria, Guillaume Habif, Francois Le Floch, Laura Chiossone, Romain Remark, Marie Vetizou, Nadia Maurel, Laurent Gauthier, Yannis Morel, Carine Paturel, Eric Vivier, Pascale Andre