Article
Neurosciences
Jae-Hong Kim, Osung Kwon, Anup Bhusal, Jiyoun Lee, Eun Mi Hwang, Hoon Ryu, Jae-Yong Park, Kyoungho Suk
Summary: This study reports the generation and characterization of conditional transgenic mice for lipocalin-2 (LCN2) expression. By delivering Cre recombinase under the control of a GFAP promoter, targeted overexpression of LCN2 in astrocytes of the hippocampus was achieved. These mice showed neuroinflammation, enhanced glial activation, increased proinflammatory cytokines, and impaired cognitive functions, providing a new in vivo model for neuroinflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stephanie Clerget-Froidevaux, Valerie Enderlin
Summary: This study investigated the protective mechanisms linking hypothyroidism and neuroinflammation. Hypothyroid WSB/EiJ mice showed no neuroinflammatory response and maintained hippocampal thyroid signaling despite low circulating thyroid hormone levels, while C57BL/6J mice exhibited disturbed thyroid signaling, accompanied by neuroinflammation and memory impairment. The results highlight the importance of the hippocampal thyroid regulatory system in glial reactivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Si-Yao Lu, Chong-Lei Fu, Liang Liang, Bo Yang, Wei Shen, Qiu-Wen Wang, Yun Chen, Yan-Fen Chen, Yao-Nan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, Jun Yao
Summary: miR-218-2 plays a crucial role in the cognitive functions of mice by regulating C3 to affect presynaptic functions, and synaptic and learning deficits can be rescued by restoring C3 activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Liyao Dong, Lin Zhang, Xinyun Zhao, Hongling Zou, Sisi Lin, Xinping Zhu, Jili Cao, Chun Zhou, Zhihong Yu, Yongqiang Zhu, Kequn Chai, Mingqian Li, Qun Li
Summary: This study elucidates the molecular mechanism whereby CYP4A22-AS1 overexpression promotes LUAD progression through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Fernando Cruz-Mendoza, Sonia Luquin, Joaquin Garcia-Estrada, David Fernandez-Quezada, Fernando Jauregui-Huerta
Summary: This study investigated the effects of acoustic stress on hippocampal proliferation and glial cytoarchitecture in adult male rats using environmental noise as a stress model. The results showed abnormal cellular proliferation in the hippocampus after 21 days of noise exposure, with an inverse effect on the proliferation ratios of astrocytes and microglia. Both cell lineages also displayed atrophic morphologies with fewer processes and lower densities in the noise-stressed animals. These findings suggest that stress not only affects neurogenesis and neuronal death in the hippocampus, but also the proliferation ratio, cell density, and morphology of glial cells, potentially triggering an inflammatory-like response that compromises their homeostatic and repair functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Bo Yang, Ruicheng Yang, Bojie Xu, Jiyang Fu, Xinyi Qu, Liang Li, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: E. coli infection induced upregulation of miR-155 and miR-146a in astrocytes, which modulated bacteria-triggered neuroinflammatory responses through negative feedback regulation involving the TLR-mediated NF-kappa B and EGFR-NF-kappa B signaling pathways, thus protecting the central nervous system from further neuroinflammatory damage.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Yao-Hui Tian, Lin-Wei Jia, Zhi-Feng Liu, Yong-Han Chen
Summary: The study confirmed that LINC01087 is highly expressed in gliomas and participates in glioma growth through the miR384/Bcl-2 axis, making it a potential therapeutic target.
Article
Cell Biology
Yu Li, Guanghui Sun, Luqiang Wang
Summary: This study investigated the relationship between miR-21 and LPS-induced myocardial injury and its molecular mechanisms. The results showed that down-regulation or antagonism of miR-21 protected myocardial cells against LPS-induced apoptosis and inflammation by up-regulating Bcl-2 and CDK6 expression, which could provide new insights for the prevention and treatment of myocardial injury.
INFLAMMATION RESEARCH
(2022)
Article
Chemistry, Medicinal
Clement Veys, Manon Jammes, Francoise Redini, Laurent Poulain, Christophe Denoyelle, Florence Legendre, Philippe Galera
Summary: This study identifies the tumor-suppressive activity of miR-342-5p and miR-491-5p in osteosarcoma cells. Both miRNAs induce apoptosis and target different proteins, offering potential for therapeutic intervention in osteosarcomas.
Article
Cell Biology
Honglin Yan, Wenxian Huang, Jie Rao, Jingping Yuan
Summary: miR-21 exhibits anti-apoptotic and pro-survival effects in ischemia by regulating the p53/Bcl-2/Bax signaling pathway, suggesting it as an attractive therapeutic molecule for ischemic stroke treatment.
Article
Chemistry, Medicinal
Maryam Mohammadlou, Maryam Abdollahi, Maral Hemati, Rasoul Baharlou, Ehsan Manouchehri Doulabi, Mehrnoosh Pashaei, Farahnaz Ghahremanfard, Mohammad Faranoush, Parviz Kokhaei
Summary: Berberine can induce apoptosis in CLL cells by reducing the expression levels of Bcl-2, ROR1, and miR-21, providing a potential novel apoptosis inducer.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Yuan Zhuang, Xiaojian Xu, Hao Li, Fei Niu, Mengshi Yang, Qianqian Ge, Shenghua Lu, Yu Deng, Hongbin Wu, Bin Zhang, Baiyun Liu
Summary: The study aims to investigate the phagocytosis of synapses by astrocytes in the ipsilateral hippocampus after traumatic brain injury (TBI). Through controlled cortical impact in mice, the researchers found a reduction in excitatory postsynaptic materials in the ipsilateral hippocampus during the subacute stage post-TBI, which was associated with cognitive dysfunction. They also identified phagocytic astrocytes containing secondary lysosomes wrapped around synapses and an increase in the co-location of GFAP and PSD-95, suggesting astrocytic engulfment of synaptic proteins. The study highlighted the role of Megf10 in astrocytic engulfment and its contribution to cognitive dysfunction following severe TBI in the CA1 region of the ipsilateral hippocampus.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Chen Hong, Zhi Wang, Si-li Zheng, Wen-jun Hu, Shu-na Wang, Yan Zhao, Chao-yu Miao
Summary: Aging is a main risk factor for cognitive dysfunction, and Metrnl, a neurotrophic factor, has been found to regulate cognitive functions and hippocampal BDNF levels during the aging process. Metrnl may become a new candidate for the treatment or alleviation of aging-related cognitive dysfunction.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Medicine, Research & Experimental
Suresh L. Mehta, Anil K. Chokkalla, Saivenkateshkomal Bathula, Vijay Arruri, Bharath Chelluboina, Raghu Vemuganti
Summary: Reconstitution of CDR1as is neuroprotective after stroke, possibly by protecting miR-7 and preventing a-Syn-mediated neuronal death.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)