Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock

Progranulin protects against renal ischemia/reperfusion injury in mice

(2015) Meng Zhou et al.   KIDNEY INTERNATIONAL

Blocking Cold-Inducible RNA-Binding Protein Protects Liver From Ischemia-Reperfusion Injury

(2015) Andrew Godwin et al.   SHOCK

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2

(2014) Meiling Li et al.   CELLULAR SIGNALLING

Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity

(2014) Cui Liu et al.   PLoS One

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner

(2014) Fanhua Wei et al.   Scientific Reports

Mesenchymal stromal cell ciliogenesis is abrogated in response to tumor necrosis factor-α and requires NF-κB signaling

(2013) Amélie Vézina et al.   CANCER LETTERS

Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice

(2013) Ryota Kawase et al.   CARDIOVASCULAR RESEARCH

Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice

(2013) Yun-Peng Zhao et al.   FEBS LETTERS

Grape seed procyanidin extract reduces the endotoxic effects induced by lipopolysaccharide in rats

(2013) Victor Pallarès et al.   FREE RADICAL BIOLOGY AND MEDICINE

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment

(2013) Yusuke Egashira et al.   Journal of Neuroinflammation

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue

(2012) Toshiya Matsubara et al.   Cell Metabolism

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

(2012) Lauren Herl Martens et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin

(2012) Zhongliang Guo et al.   MEDIATORS OF INFLAMMATION

Mucosal Progranulin expression is induced by H. pylori, but independent of Secretory Leukocyte Protease Inhibitor (SLPI) expression

(2011) Thomas Wex et al.   BMC GASTROENTEROLOGY

Upregulation of progranulin byHelicobacter pyloriin human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration

(2011) Hongyan Wang et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoprotein

(2011) Juan Liu et al.   GYNECOLOGIC ONCOLOGY

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

(2011) Boyoun Park et al.   IMMUNITY

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

The granulin gene family: from cancer to dementia

(2009) Andrew Bateman et al.   BIOESSAYS

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia

(2008) Helen M. Marriott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sepsis Strategies in Development

(2008) Steven P. LaRosa et al.   CLINICS IN CHEST MEDICINE

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE