MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN

MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis

(2016) SHIJU YAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice

(2016) Siru Zhou et al.   Scientific Reports

The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1

(2016) Vanessa Abella et al.   Scientific Reports

Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling

(2015) Yan Zhou et al.   APOPTOSIS

MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2

(2015) Huajiang Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice

(2015) Yun-peng Zhao et al.   Scientific Reports

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

(2014) Yun-peng Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of microRNA-145 on IL-1β-induced cartilage degradation in human chondrocytes

(2014) Bo Yang et al.   FEBS LETTERS

The role of PGRN in musculoskeletal development and disease

(2014) Jessica Konopka   Frontiers in Bioscience-Landmark

Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro

(2014) LEI JIN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Akt signaling

(2014) Yumin Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

FOXO3A Regulation by miRNA-29a Controls Chondrogenic Differentiation of Mesenchymal Stem Cells and Cartilage Formation

(2014) David Guérit et al.   STEM CELLS AND DEVELOPMENT

microRNA-mediated regulation of the tumor microenvironment

(2013) Jonathan Chou et al.   CELL CYCLE

miR-29b suppresses CML cell proliferation and induces apoptosis via regulation of BCR/ABL1 protein

(2013) Yajuan Li et al.   EXPERIMENTAL CELL RESEARCH

Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease

(2013) Zaitunnatakhin Zamli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

(2012) Jing Li et al.   ARTHRITIS RESEARCH & THERAPY

Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1

(2011) Yi-Kun Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates

(2011) Chao Yan et al.   BIOMATERIALS

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury

(2011) Guodong Shi et al.   EXPERIMENTAL BRAIN RESEARCH

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma

(2010) Maria Angelica Cortez et al.   GENES CHROMOSOMES & CANCER

TNF-α mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis Through FOXO1

(2010) Rayyan A Kayal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia

(2010) Jian Jiao et al.   PLoS One

Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro

(2010) M. M. Abouheif et al.   RHEUMATOLOGY

Variations in chondrocyte apoptosis may explain the increased prevalence of osteoarthritis in some joints

(2010) C. M. Thomas et al.   RHEUMATOLOGY INTERNATIONAL

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

(2008) Dimitrios Iliopoulos et al.   PLoS One

Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression

(2008) Masaya Hayashi et al.   ARTHRITIS RESEARCH & THERAPY