The Quest for Osteoporosis Mechanisms and Rational Therapies: How Far We've Come, How Much Further We Need to Go

Increased osteoclastogenesis in patients with vertebral fractures following discontinuation of denosumab treatment

(2017) Athanasios D Anastasilakis et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3 , Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites

(2017) Alessandra Chesi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Estrogens and Androgens in Skeletal Physiology and Pathophysiology

(2017) Maria Almeida et al.   PHYSIOLOGICAL REVIEWS

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

(2017) Jun Li et al.   SCIENCE

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

(2017) Kayvan Zainabadi et al.   PLoS One

Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice

(2016) Yu Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Age- and Sex-Related Changes in Bone Microarchitecture and Estimated Strength: A Three-Year Prospective Study Using HRpQCT

(2016) Vikram V Shanbhogue et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct

(2016) Serra Ucer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification of Senescent Cells in the Bone Microenvironment

(2016) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Multiple myeloma–derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

(2016) Jing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

(2016) Zeynep Madak-Erdogan et al.   Science Signaling

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

(2016) Zeynep Madak-Erdogan et al.   Science Signaling

Spatial distribution of intracortical porosity varies across age and sex

(2015) Jasmine A. Nirody et al.   BONE

The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERα Signaling in Osteoblasts and Osteoclasts

(2015) Serra Ucer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

(2015) Ha-Neui Kim et al.   MOLECULAR ENDOCRINOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Rebound-associated vertebral fractures after discontinuation of denosumab—from clinic and biomechanics

(2015) A. W. Popp et al.   OSTEOPOROSIS INTERNATIONAL

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Healthy aging: The ultimate preventative medicine

(2015) M. Kaeberlein et al.   SCIENCE

Sex Steroid Actions in Male Bone

(2014) Dirk Vanderschueren et al.   ENDOCRINE REVIEWS

Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors

(2014) Srividhya Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new Ediacaran fossil with a novel sediment displacive life habit

(2014) Mary L. Droser et al.   JOURNAL OF PALEONTOLOGY

Wnt signaling and osteoporosis

(2014) Stavros C. Manolagas   MATURITAS

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation

(2014) Shoshana M. Bartell et al.   Nature Communications

The Influence of Innate and Adaptive Immune Responses on Atherosclerosis

(2013) Joseph L. Witztum et al.   Annual Review of Pathology-Mechanisms of Disease

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

(2013) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysapoptosis of Osteoblasts and Osteocytes Increases Cancellous Bone Formation But Exaggerates Cortical Porosity With Age

(2013) Robert L Jilka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FOXOs attenuate bone formation by suppressing Wnt signaling

(2013) Srividhya Iyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Basic Biology of Skeletal Aging: Role of Stress Response Pathways

(2013) M. Almeida et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Non-Nuclear–Initiated Actions of the Estrogen Receptor Protect Cortical Bone Mass

(2013) Shoshana M. Bartell et al.   MOLECULAR ENDOCRINOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

The role of estrogen and androgen receptors in bone health and disease

(2013) Stavros C. Manolagas et al.   Nature Reviews Endocrinology

Effects of bioactive lipids and lipoproteins on bone

(2013) Yin Tintut et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Senescence in natural populations of animals: Widespread evidence and its implications for bio-gerontology

(2012) Daniel H. Nussey et al.   AGEING RESEARCH REVIEWS

Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations

(2012) Oran D. Kennedy et al.   BONE

For whom the bell tolls: Distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases

(2012) Stavros C. Manolagas et al.   BONE

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid   production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

(2012) P. Mao et al.   HUMAN MOLECULAR GENETICS

Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: Evidence from targeted AR disruption in mouse osteocytes

(2012) Mieke Sinnesael et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual

(2012) Maria Almeida et al.   JOURNAL OF CLINICAL INVESTIGATION

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

(2010) Dao-Fu Dai et al.   AGING CELL

Oxidized Low-Density Lipoprotein and Atherosclerosis

(2010) Daniel Steinberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis

(2010) A.M. Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

(2010) Ken L. Chambliss et al.   JOURNAL OF CLINICAL INVESTIGATION

The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone

(2010) Marta Martin-Millan et al.   MOLECULAR ENDOCRINOLOGY

What old means to bone

(2010) Stavros C. Manolagas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insights from comparative analyses of aging in birds and mammals

(2009) Robert E. Ricklefs   AGING CELL

Osteocyte apoptosis and control of bone resorption following ovariectomy in mice

(2009) K.B. Emerton et al.   BONE

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

(2009) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

(2009) G. Dewson et al.   JOURNAL OF CELL SCIENCE

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Association between serum cholesterol and bone mineral density

(2008) Joanna Makovey et al.   BONE

Mineralization and Bone Resorption Are Regulated by the Androgen Receptor in Male Mice

(2008) Cherie Chiang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of osteoblastic metalloproteinases in mice prevents bone loss induced by oestrogen deficiency

(2008) Corinne Schiltz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY