The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct

The Role of Osteocytes in Age-Related Bone Loss

(2016) Robert L. Jilka et al.   Current Osteoporosis Reports

Measurement of a Comprehensive Sex Steroid Profile in Rodent Serum by High-Sensitive Gas Chromatography-Tandem Mass Spectrometry

(2015) Maria E. Nilsson et al.   ENDOCRINOLOGY

The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERα Signaling in Osteoblasts and Osteoclasts

(2015) Serra Ucer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis

(2015) Keiji Kobayashi et al.   Scientific Reports

NADPH Oxidase–Generated Reactive Oxygen Species Are Required for Stromal Cell–Derived Factor-1α–Stimulated Angiogenesis

(2014) Xinchun Pi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells

(2014) Jin Young Im et al.   BMB Reports

Sex Steroid Actions in Male Bone

(2014) Dirk Vanderschueren et al.   ENDOCRINE REVIEWS

Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways

(2014) Manoj K. Pandey et al.   EXPERIMENTAL HEMATOLOGY

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation

(2014) Shoshana M. Bartell et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

(2013) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysapoptosis of Osteoblasts and Osteocytes Increases Cancellous Bone Formation But Exaggerates Cortical Porosity With Age

(2013) Robert L Jilka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FOXOs attenuate bone formation by suppressing Wnt signaling

(2013) Srividhya Iyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Basic Biology of Skeletal Aging: Role of Stress Response Pathways

(2013) M. Almeida et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

The role of estrogen and androgen receptors in bone health and disease

(2013) Stavros C. Manolagas et al.   Nature Reviews Endocrinology

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

For whom the bell tolls: Distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases

(2012) Stavros C. Manolagas et al.   BONE

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid   production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

(2012) P. Mao et al.   HUMAN MOLECULAR GENETICS

Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: Evidence from targeted AR disruption in mouse osteocytes

(2012) Mieke Sinnesael et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual

(2012) Maria Almeida et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Relationship of age to bone microstructure independent of areal bone mineral density

(2011) Kristy M Nicks et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration

(2010) Robert L. Jilka et al.   AGING CELL

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis

(2010) A.M. Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed?

(2010) Sundeep Khosla et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study

(2010) Roger MD Zebaze et al.   LANCET

The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone

(2010) Marta Martin-Millan et al.   MOLECULAR ENDOCRINOLOGY

What old means to bone

(2010) Stavros C. Manolagas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients

(2009) Patrick Coipeau et al.   CYTOTHERAPY

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Insights into Mesenchymal Stem Cell Aging: Involvement of Antioxidant Defense and Actin Cytoskeleton

(2009) Grit Kasper et al.   STEM CELLS

Mineralization and Bone Resorption Are Regulated by the Androgen Receptor in Male Mice

(2008) Cherie Chiang et al.   JOURNAL OF BONE AND MINERAL RESEARCH