Drug permeation and metabolism in Mycobacterium tuberculosis : Prioritising local exposure as essential criterion in new TB drug development
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Drug permeation and metabolism in Mycobacterium tuberculosis
: Prioritising local exposure as essential criterion in new TB drug development
Authors
Keywords
-
Journal
IUBMB LIFE
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2018-06-23
DOI
10.1002/iub.1866
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Role of Efflux Pumps in Tuberculosis Treatment and Their Promise as a Target in Drug Development: Unraveling the Black Box
- (2018) Lindsey H.M. te Brake et al. Annual Review of Pharmacology and Toxicology
- Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis
- (2018) Chao Chen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice
- (2018) Stephen T Reece et al. JOURNAL OF INFECTIOUS DISEASES
- The global burden of tuberculosis: results from the Global Burden of Disease Study 2015
- (2018) Hmwe H Kyu et al. LANCET INFECTIOUS DISEASES
- Visualization of mycobacterial membrane dynamics in live cells
- (2017) Frances P. Rodriguez-Rivera et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis
- (2017) Alyssa J. Manning et al. METHODS
- Dynamic Fluorescence Microscopy of Cellular Uptake of Intercalating Model Drugs by Ultrasound-Activated Microbubbles
- (2017) B.H.A. Lammertink et al. MOLECULAR IMAGING AND BIOLOGY
- Rifamycin action on RNA polymerase in antibiotic-tolerantMycobacterium tuberculosisresults in differentially detectable populations
- (2017) Kohta Saito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery
- (2017) Divya Awasthi et al. TRENDS IN MICROBIOLOGY
- Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis
- (2017) Constance J. Martin et al. mBio
- A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis
- (2017) Magdalena K. Bielecka et al. mBio
- Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
- (2017) Elsje Pienaar et al. PLoS Computational Biology
- Mycobacterium tuberculosis infection modulates adipose tissue biology
- (2017) Macarena Beigier-Bompadre et al. PLoS Pathogens
- Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model
- (2017) Liku B Tezera et al. eLife
- Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins
- (2017) Silvia Scarabelli et al. ACS Sensors
- Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis
- (2017) Murat Cokol et al. Science Advances
- New agents for the treatment of drug-resistant Mycobacterium tuberculosis
- (2016) Daniel T. Hoagland et al. ADVANCED DRUG DELIVERY REVIEWS
- A New Method and Mass Spectrometer Design for TOF-SIMS Parallel Imaging MS/MS
- (2016) Gregory L. Fisher et al. ANALYTICAL CHEMISTRY
- Toward an Evidence-Based Nonclinical Road Map for Evaluating the Efficacy of New Tuberculosis (TB) Drug Regimens: Proceedings of a Critical Path to TB Drug Regimens-National Institute of Allergy and Infectious DiseasesIn VivoPharmacology Workshop for TB Drug Development
- (2016) Eric Nuermberger et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetics of Rifampin, Isoniazid, Pyrazinamide, and Ethambutol in Infants Dosed According to Revised WHO-Recommended Treatment Guidelines
- (2016) A. Bekker et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Imaging mass spectrometry in drug development and toxicology
- (2016) Oskar Karlsson et al. ARCHIVES OF TOXICOLOGY
- A Macrophage Infection Model to Predict Drug Efficacy Against Mycobacterium Tuberculosis
- (2016) Kaitlyn Schaaf et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Immune activation of the host cell induces drug tolerance inMycobacterium tuberculosisboth in vitro and in vivo
- (2016) Yancheng Liu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Absolute Quantification of Rifampicin by MALDI Imaging Mass Spectrometry Using Multiple TOF/TOF Events in a Single Laser Shot
- (2016) Boone M. Prentice et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers
- (2016) Robert S Wallis et al. LANCET INFECTIOUS DISEASES
- New insights into the multidimensional concept of macrophage ontogeny, activation and function
- (2016) Florent Ginhoux et al. NATURE IMMUNOLOGY
- N-methylation of a bactericidal compound as a resistance mechanism inMycobacterium tuberculosis
- (2016) Thulasi Warrier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice
- (2016) Scott M. Irwin et al. ACS Infectious Diseases
- Prediction of Drug Penetration in Tuberculosis Lesions
- (2016) Jansy P. Sarathy et al. ACS Infectious Diseases
- Nicotinate-Curcumin Impedes Foam Cell Formation from THP-1 Cells through Restoring Autophagy Flux
- (2016) Hong-Feng Gu et al. PLoS One
- Autoradiography techniques and quantification of drug distribution
- (2015) Eric G. Solon CELL AND TISSUE RESEARCH
- Systematic Analysis of Hollow Fiber Model of Tuberculosis Experiments
- (2015) Jotam G. Pasipanodya et al. CLINICAL INFECTIOUS DISEASES
- Advances in measuring single-cell pharmacology in vivo
- (2015) Claudio Vinegoni et al. DRUG DISCOVERY TODAY
- Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
- (2015) Anne Lenaerts et al. IMMUNOLOGICAL REVIEWS
- Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them
- (2015) Dimitrios Evangelopoulos et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Nonclinical Models for Antituberculosis Drug Development: A Landscape Analysis
- (2015) Tawanda Gumbo et al. JOURNAL OF INFECTIOUS DISEASES
- Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model
- (2015) Michael A. Lyons et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis
- (2015) Rodney Dawson et al. LANCET
- The association between sterilizing activity and drug distribution into tuberculosis lesions
- (2015) Brendan Prideaux et al. NATURE MEDICINE
- Treatment of Tuberculosis
- (2015) C. Robert Horsburgh et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies
- (2015) Igor Kramnik et al. Seminars in Immunopathology
- Confocal fluorescence microscopy: An ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cells
- (2015) Subhra Mandal et al. AIP Advances
- Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment
- (2015) Brian C. VanderVen et al. PLoS Pathogens
- Understanding pharmacokinetics to improve tuberculosis treatment outcome
- (2014) Jonathan Reynolds et al. Expert Opinion on Drug Metabolism & Toxicology
- Beyond macrophages: the diversity of mononuclear cells in tuberculosis
- (2014) Smita Srivastava et al. IMMUNOLOGICAL REVIEWS
- Verapamil, and Its Metabolite Norverapamil, Inhibit Macrophage-induced, Bacterial Efflux Pump-mediated Tolerance to Multiple Anti-tubercular Drugs
- (2014) Kristin N. Adams et al. JOURNAL OF INFECTIOUS DISEASES
- The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells
- (2014) Véronique Dartois NATURE REVIEWS MICROBIOLOGY
- Shortening Treatment for Tuberculosis — Back to Basics
- (2014) Digby F. Warner et al. NEW ENGLAND JOURNAL OF MEDICINE
- Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis
- (2014) Stephen H. Gillespie et al. NEW ENGLAND JOURNAL OF MEDICINE
- Acquired Drug Resistance Because of Pharmacokinetic Variability in a Young Child With Tuberculosis
- (2014) Jotam G. Pasipanodya et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Replication Rates of Mycobacterium tuberculosis in Human Macrophages Do Not Correlate with Mycobacterial Antibiotic Susceptibility
- (2014) Johanna Raffetseder et al. PLoS One
- Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides
- (2014) Ritu Bansal-Mutalik et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vitro–in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis
- (2014) Susan E. Knudson et al. TUBERCULOSIS
- Molecular imaging of targeted therapies with positron emission tomography: the visualization of personalized cancer care
- (2014) Lemonitsa H. Mammatas et al. CELLULAR ONCOLOGY
- Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth
- (2014) Sarah A. Stanley et al. PLoS Pathogens
- Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model
- (2013) Sarah Schmidt Grant et al. ACS Chemical Biology
- The Immune Response in Tuberculosis
- (2013) Anne O'Garra et al. Annual Review of Immunology
- Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis
- (2013) Jansy Sarathy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Involvement of Efflux Pumps in the Resistance to Peptidoglycan Synthesis Inhibitors in Mycobacterium tuberculosis
- (2013) Neela Dinesh et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A medicinal chemists’ guide to the unique difficulties of lead optimization for tuberculosis
- (2013) Véronique Dartois et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing
- (2013) Yanjia J. Zhang et al. CELL
- The evolutionary pressures that have molded Mycobacterium tuberculosis into an infectious adjuvant
- (2013) David G Russell CURRENT OPINION IN MICROBIOLOGY
- Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes
- (2013) J. G. Pasipanodya et al. JOURNAL OF INFECTIOUS DISEASES
- LC–MS based assay to measure intracellular compound levels in Mycobacterium smegmatis : Linking compound levels to cellular potency
- (2013) Jyothi Bhat et al. JOURNAL OF MICROBIOLOGICAL METHODS
- Metabolomics Analysis Identifies d-Alanine-d-Alanine Ligase as the Primary Lethal Target of d-Cycloserine in Mycobacteria
- (2013) Steven Halouska et al. JOURNAL OF PROTEOME RESEARCH
- The Mycobacterium tuberculosis regulatory network and hypoxia
- (2013) James E. Galagan et al. NATURE
- Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
- (2013) Kevin Pethe et al. NATURE MEDICINE
- Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
- (2013) Philana Ling Lin et al. NATURE MEDICINE
- Drug Resistant Clinical Isolates of Mycobacterium tuberculosis from Different Genotypes Exhibit Differential Host Responses in THP-1 Cells
- (2013) Pampi Chakraborty et al. PLoS One
- Quantitative Analysis of Microbicide Concentrations in Fluids, Gels and Tissues Using Confocal Raman Spectroscopy
- (2013) Oranat Chuchuen et al. PLoS One
- Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions
- (2013) G. Fejer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Approval of Novel TB Drug Celebrated--With Restraint
- (2013) J. Cohen SCIENCE
- Dynamic Persistence of Antibiotic-Stressed Mycobacteria
- (2013) Y. Wakamoto et al. SCIENCE
- Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis
- (2013) Gareth A. Prosser et al. ACS Medicinal Chemistry Letters
- Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates
- (2012) Meenakshi Balganesh et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy
- (2012) Jotam G. Pasipanodya et al. CLINICAL INFECTIOUS DISEASES
- The chemotherapy of tuberculosis: past, present and future [State of the art]
- (2012) D. Mitchison et al. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
- Extrapulmonary Locations of Mycobacterium tuberculosis DNA During Latent Infection
- (2012) Jorge Barrios-Payán et al. JOURNAL OF INFECTIOUS DISEASES
- Predicting the in Vivo Mechanism of Action for Drug Leads Using NMR Metabolomics
- (2011) Steven Halouska et al. ACS Chemical Biology
- High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions
- (2011) Brendan Prideaux et al. ANALYTICAL CHEMISTRY
- Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions
- (2011) Maria C. Kjellsson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetics of Isoniazid, Rifampin, and Pyrazinamide in Children Younger than Two Years of Age with Tuberculosis: Evidence for Implementation of Revised World Health Organization Recommendations
- (2011) S. Thee et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Understanding the time course of pharmacological effect: a PKPD approach
- (2011) Daniel F. B. Wright et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Positron emission tomography molecular imaging for drug development
- (2011) Paul M. Matthews et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism
- (2011) Kristin N. Adams et al. CELL
- High-content screening in infectious diseases
- (2011) Priscille Brodin et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Detailed Structural and Quantitative Analysis Reveals the Spatial Organization of the Cell Walls ofin VivoGrownMycobacterium lepraeandin VitroGrownMycobacterium tuberculosis
- (2011) Suresh Bhamidi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Macrophages and control of granulomatous inflammation in tuberculosis
- (2011) J L Flynn et al. Mucosal Immunology
- The challenge of new drug discovery for tuberculosis
- (2011) Anil Koul et al. NATURE
- Neutrophils in tuberculosis: friend or foe?
- (2011) David M. Lowe et al. TRENDS IN IMMUNOLOGY
- Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates
- (2010) Luiz Pedro S. de Carvalho et al. CHEMISTRY & BIOLOGY
- In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB
- (2010) Pavan K Vaddady et al. Future Medicinal Chemistry
- Tuberculosis: What We Don't Know Can, and Does, Hurt Us
- (2010) D. G. Russell et al. SCIENCE
- Mycobacterial outer membranes: in search of proteins
- (2010) Michael Niederweis et al. TRENDS IN MICROBIOLOGY
- A Balancing Act: Efflux/Influx in Mycobacterial Drug Resistance
- (2009) G. E. Louw et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mycobacterial survival strategies in the phagosome: defence against host stresses
- (2009) Sabine Ehrt et al. CELLULAR MICROBIOLOGY
- Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB
- (2009) Seok-Yong Eum et al. CHEST
- Acid Resistance in Mycobacterium tuberculosis
- (2009) O. H. Vandal et al. JOURNAL OF BACTERIOLOGY
- Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability
- (2009) M. Gengenbacher et al. MICROBIOLOGY-SGM
- Nuclear Microscopy: A Novel Technique for Quantitative Imaging of Gadolinium Distribution within Tissue Sections
- (2009) Reshmi Rajendran et al. MICROSCOPY AND MICROANALYSIS
- The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
- (2009) Clifton E. Barry et al. NATURE REVIEWS MICROBIOLOGY
- Drug efflux pump deficiency and drug target resistance masking in growing bacteria
- (2009) D. Fange et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development
- (2008) J. van den Boogaard et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Direct visualization and quantification of the anticancer agent, cis-diamminedichloro-platinum(II), in human lung cancer cells using in-air microparticle-induced X-ray emission analysis
- (2008) Hideyuki Sakurai et al. CANCER SCIENCE
- Physiological heterogeneity in biofilms
- (2008) Philip S. Stewart et al. NATURE REVIEWS MICROBIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now