Nonclinical Models for Antituberculosis Drug Development: A Landscape Analysis

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

(2015) J.-P. Lanoix et al.   Disease Models & Mechanisms

Pharmacokinetic-Pharmacodynamic and Dose-Response Relationships of Antituberculosis Drugs: Recommendations and Standards for Industry and Academia

(2015) Tawanda Gumbo et al.   JOURNAL OF INFECTIOUS DISEASES

Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis

(2015) Rodney Dawson et al.   LANCET

Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis

(2014) Emmanuel Chigutsa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

1,4-Azaindole, a Potential Drug Candidate for Treatment of Tuberculosis

(2014) Monalisa Chatterji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Radioiodinated DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice

(2014) Alvaro A. Ordonez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas

(2014) Scott M. Irwin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis

(2014) Stephen H. Gillespie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acquired Drug Resistance Because of Pharmacokinetic Variability in a Young Child With Tuberculosis

(2014) Jotam G. Pasipanodya et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Pharmacokinetics and dose response of anti-TB drugs in rat infection model of tuberculosis

(2014) Naveen Kumar et al.   TUBERCULOSIS

Efficacy and Safety of Metronidazole for Pulmonary Multidrug-Resistant Tuberculosis

(2013) Matthew W. Carroll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potent Rifamycin-Sparing Regimen Cures Guinea Pig Tuberculosis as Rapidly as the Standard Regimen

(2013) Noton K. Dutta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Thioridazine Pharmacokinetic-Pharmacodynamic Parameters “Wobble” during Treatment of Tuberculosis: a Theoretical Basis for Shorter-Duration Curative Monotherapy with Congeners

(2013) Sandirai Musuka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

(2013) Philana Ling Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Meta-Analysis of Self-Administered vs Directly Observed Therapy Effect on Microbiologic Failure, Relapse, and Acquired Drug Resistance in Tuberculosis Patients

(2013) Jotam G. Pasipanodya et al.   CLINICAL INFECTIOUS DISEASES

Macaque Models of Human Infectious Disease

(2013) M. B. Gardner et al.   ILAR JOURNAL

Differential Virulence and Disease Progression following Mycobacterium tuberculosis Complex Infection of the Common Marmoset (Callithrix jacchus)

(2013) Laura E. Via et al.   INFECTION AND IMMUNITY

Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes

(2013) J. G. Pasipanodya et al.   JOURNAL OF INFECTIOUS DISEASES

Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [18F]2-Fluoro-Deoxy-d-Glucose Positron Emission Tomography and Computed Tomography

(2012) Laura E. Via et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sterilizing Activities of Novel Combinations Lacking First- and Second-Line Drugs in a Murine Model of Tuberculosis

(2012) Kathy Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rifapentine Is Not More Active than Rifampin against Chronic Tuberculosis in Guinea Pigs

(2012) Noton K. Dutta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis

(2012) Emily R. Driver et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Antibiotic Resistance Arrow of Time: Efflux Pump Induction Is a General First Step in the Evolution of Mycobacterial Drug Resistance

(2012) Aurelia M. Schmalstieg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dose-Ranging Comparison of Rifampin and Rifapentine in Two Pathologically Distinct Murine Models of Tuberculosis

(2012) Ian M. Rosenthal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy

(2012) Jotam G. Pasipanodya et al.   CLINICAL INFECTIOUS DISEASES

In Vitro and In Vivo Modeling of Tuberculosis Drugs and its Impact on Optimization of Doses and Regimens

(2012) Shashikant Srivastava et al.   CURRENT PHARMACEUTICAL DESIGN

Substitution of Rifapentine for Rifampin During Intensive Phase Treatment of Pulmonary Tuberculosis: Study 29 of the Tuberculosis Trials Consortium

(2012) S. E. Dorman et al.   JOURNAL OF INFECTIOUS DISEASES

14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial

(2012) Andreas H Diacon et al.   LANCET

Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

(2012) P. L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis

(2012) Scott G. Franzblau et al.   TUBERCULOSIS

Treatment of Tuberculosis with Rifamycin-containing Regimens in Immune-deficient Mice

(2011) Ming Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Short-Course Chemotherapy with TMC207 and Rifapentine in a Murine Model of Latent Tuberculosis Infection

(2011) Tianyu Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions

(2011) Brendan Prideaux et al.   ANALYTICAL CHEMISTRY

Sterilizing Activity of Novel TMC207- and PA-824-Containing Regimens in a Murine Model of Tuberculosis

(2011) Rokeya Tasneen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetic Mismatch Does Not Lead to Emergence of Isoniazid- or Rifampin-Resistant Mycobacterium tuberculosis but to Better Antimicrobial Effect: a New Paradigm for Antituberculosis Drug Scheduling

(2011) Shashikant Srivastava et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions

(2011) Maria C. Kjellsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Course of murine tuberculosis and response to first-line therapy depends on route of infection and inoculum size

(2011) J.E.M. de Steenwinkel et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models

(2011) Z. Ahmad et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Multidrug-Resistant Tuberculosis Not Due to Noncompliance but to Between-Patient Pharmacokinetic Variability

(2011) Shashikant Srivastava et al.   JOURNAL OF INFECTIOUS DISEASES

Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions

(2011) Jamie Harper et al.   JOURNAL OF INFECTIOUS DISEASES

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment

(2011) Donald R. Hoff et al.   PLoS One

Experimental Tuberculosis in the Wistar Rat: A Model for Protective Immunity and Control of Infection

(2011) Amit Singhal et al.   PLoS One

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

(2011) YiXiong Heng et al.   TUBERCULOSIS

Effect of Administration of Moxifloxacin plus Rifampin against Mycobacterium tuberculosis for 7 of 7 Days versus 5 of 7 Days in an In Vitro Pharmacodynamic System

(2011) G. L. Drusano et al.   mBio

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response

(2011) S. Subbian et al.   Open Biology

Bactericidal Potencies of New Regimens Are Not Predictive of Their Sterilizing Potencies in a Murine Model of Tuberculosis

(2010) K. Andries et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Oracle: Antituberculosis Pharmacokinetics-Pharmacodynamics, Clinical Correlation, and Clinical Trial Simulations To Predict the Future

(2010) Jotam Pasipanodya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of Standard Chemotherapy in the Guinea Pig Model of Tuberculosis

(2010) D. J. Ordway et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activities of TMC207, Rifampin, and Pyrazinamide againstMycobacterium tuberculosisInfection in Guinea Pigs

(2010) Shaobin Shang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative Studies Evaluating Mouse Models Used for Efficacy Testing of Experimental Drugs againstMycobacterium tuberculosis

(2010) Mary A. De Groote et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis

(2010) J. E. M. de Steenwinkel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pig

(2010) Z. Ahmad et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Variation among Genome Sequences of H37Rv Strains of Mycobacterium tuberculosis from Multiple Laboratories

(2010) T. R. Ioerger et al.   JOURNAL OF BACTERIOLOGY

Efflux‐Pump–Derived Multiple Drug Resistance to Ethambutol Monotherapy inMycobacterium tuberculosisand the Pharmacokinetics and Pharmacodynamics of Ethambutol

(2010) Shashikant Srivastava et al.   JOURNAL OF INFECTIOUS DISEASES

Multiple M. tuberculosis Phenotypes in Mouse and Guinea Pig Lung Tissue Revealed by a Dual-Staining Approach

(2010) Gavin J. Ryan et al.   PLoS One

BCG vaccination in the cotton rat (Sigmodon hispidus) infected by the pulmonary route with virulent Mycobacterium tuberculosis

(2010) Christine T. McFarland et al.   TUBERCULOSIS

The Combination of Rifampin plus Moxifloxacin Is Synergistic for Suppression of Resistance but Antagonistic for Cell Kill of Mycobacterium tuberculosis as Determined in a Hollow-Fiber Infection Model

(2010) G. L. Drusano et al.   mBio

Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts

(2009) Alexander V. Pichugin et al.   AMERICAN JOURNAL OF PATHOLOGY

Sterilizing Activity of R207910 (TMC207)-containing Regimens in the Murine Model of Tuberculosis

(2009) Murad Ibrahim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Short-Course Therapy with Daily Rifapentine in a Murine Model of Latent Tuberculosis Infection

(2009) Tianyu Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pharmacokinetics-Pharmacodynamics of Pyrazinamide in a Novel In Vitro Model of Tuberculosis for Sterilizing Effect: a Paradigm for Faster Assessment of New Antituberculosis Drugs

(2009) T. Gumbo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

(2009) Seok-Yong Eum et al.   CHEST

T cells in mycobacterial infection and disease

(2009) Andrea M Cooper   CURRENT OPINION IN IMMUNOLOGY

Biphasic Kill Curve of Isoniazid Reveals the Presence of Drug‐Tolerant, Not Drug‐Resistant,Mycobacterium tuberculosisin the Guinea Pig

(2009) Zahoor Ahmad et al.   JOURNAL OF INFECTIOUS DISEASES

A replication clock for Mycobacterium tuberculosis

(2009) Wendy P Gill et al.   NATURE MEDICINE

Bacterial Thymidine Kinase as a Non-Invasive Imaging Reporter for Mycobacterium tuberculosis in Live Animals

(2009) Stephanie L. Davis et al.   PLoS One

Isoniazid or Moxifloxacin in Rifapentine-based Regimens for Experimental Tuberculosis?

(2008) Ian M. Rosenthal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis

(2008) D. R. Hoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis

(2008) E. Nuermberger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Extrapulmonary Dissemination of Mycobacterium bovis but Not Mycobacterium tuberculosis in a Bronchoscopic Rabbit Model of Cavitary Tuberculosis

(2008) G. G. Nedeltchev et al.   INFECTION AND IMMUNITY

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Prevention of Drug Carryover Effects in Studies Assessing Antimycobacterial Efficacy of TMC207

(2008) N. Lounis et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Using Animal Models to Develop New Treatments for Tuberculosis

(2008) Eric Nuermberger   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Preclinical testing of new drugs for tuberculosis: current challenges

(2008) Anne J. Lenaerts et al.   TRENDS IN MICROBIOLOGY