The challenge of new drug discovery for tuberculosis

Letting Sleeping dos Lie: Does Dormancy Play a Role in Tuberculosis?

(2010) Michael C. Chao et al.   Annual Review of Microbiology

Bactericidal Potencies of New Regimens Are Not Predictive of Their Sterilizing Potencies in a Murine Model of Tuberculosis

(2010) K. Andries et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis

(2010) Dhiraj Kumar et al.   CELL

Update on Research and Development Pipeline: Tuberculosis Vaccines

(2010) Belinda Beresford et al.   CLINICAL INFECTIOUS DISEASES

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

(2010) Dirk Bald et al.   FEMS MICROBIOLOGY LETTERS

Global tuberculosis drug development pipeline: the need and the reality

(2010) Zhenkun Ma et al.   LANCET

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET

Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice

(2010) Robert S Wallis et al.   LANCET

Biomarkers for tuberculosis disease activity, cure, and relapse

(2010) Robert S Wallis et al.   LANCET INFECTIOUS DISEASES

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice

(2010) N. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

(2010) B. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Population Dynamics and Control of Tuberculosis

(2010) C. Dye et al.   SCIENCE

Tuberculosis: What We Don't Know Can, and Does, Hurt Us

(2010) D. G. Russell et al.   SCIENCE

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

Sterilizing Activity of R207910 (TMC207)-containing Regimens in the Murine Model of Tuberculosis

(2009) Murad Ibrahim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pharmacokinetics of Antituberculosis Drugs in Pulmonary Tuberculosis Patients with Type 2 Diabetes

(2009) R. Ruslami et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Pharmacokinetic interactions between rifabutin and lopinavir/ritonavir in HIV-infected patients with mycobacterial co-infection

(2009) H. Khachi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Analysis of the Calculated Physicochemical Properties of Respiratory Drugs: Can We Design for Inhaled Drugs Yet?

(2009) Timothy J. Ritchie et al.   Journal of Chemical Information and Modeling

Tuberculosis and diabetes mellitus: convergence of two epidemics

(2009) Kelly E Dooley et al.   LANCET INFECTIOUS DISEASES

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

(2009) J. Richard Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model

(2008) K. N. Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis

(2008) R. Rustomjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents

(2008) Shinpei Hirano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance

(2008) Jean Pieters   Cell Host & Microbe

A novel drug discovery concept for tuberculosis: Inhibition of bacterial and host cell signalling

(2008) Rita Székely et al.   IMMUNOLOGY LETTERS

Diarylquinolines Are Bactericidal for Dormant Mycobacteria as a Result of Disturbed ATP Homeostasis

(2008) Anil Koul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bacterial Growth and Cell Division: a Mycobacterial Perspective

(2008) E. C. Hett et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

(2008) R. Singh et al.   SCIENCE

The early bactericidal activity of anti-tuberculosis drugs: a literature review

(2008) P.R. Donald et al.   TUBERCULOSIS