Imaging mass spectrometry in drug development and toxicology

A New Method and Mass Spectrometer Design for TOF-SIMS Parallel Imaging MS/MS

(2016) Gregory L. Fisher et al.   ANALYTICAL CHEMISTRY

Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues

(2016) Chad W. Chumbley et al.   ANALYTICAL CHEMISTRY

Melanin and neuromelanin binding of drugs and chemicals: toxicological implications

(2016) Oskar Karlsson et al.   ARCHIVES OF TOXICOLOGY

Absolute Quantification of Rifampicin by MALDI Imaging Mass Spectrometry Using Multiple TOF/TOF Events in a Single Laser Shot

(2016) Boone M. Prentice et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue

(2016) Alice Ly et al.   Nature Protocols

Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain

(2016) Paul Alan Cox et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transfer of developmental neurotoxin β- N -methylamino- l -alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis

(2016) Marie Andersson et al.   TOXICOLOGY LETTERS

Spatial neuroproteomics using imaging mass spectrometry

(2015) Jörg Hanrieder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Investigating Nephrotoxicity of Polymyxin Derivatives by Mapping Renal Distribution Using Mass Spectrometry Imaging

(2015) Anna Nilsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines

(2015) Mohammadreza Shariatgorji et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Imaging MS in Toxicology: An Investigation of Juvenile Rat Nephrotoxicity Associated with Dabrafenib Administration

(2015) M. Reid Groseclose et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections

(2015) Anne L. Bruinen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Use of advantageous, volatile matrices enabled by next-generation high-speed matrix-assisted laser desorption/ionization time-of-flight imaging employing a scanning laser beam

(2015) Nina Ogrinc Potočnik et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Quantitative whole-body autoradiography: past, present and future

(2015) Andrew McEwen et al.   Bioanalysis

Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (β-N-methylamino-L-alanine) in neonatal rat brain

(2015) Oskar Karlsson et al.   Scientific Reports

High Resolution Metabolite Imaging in the Hippocampus Following Neonatal Exposure to the Environmental Toxin BMAA Using ToF-SIMS

(2014) Jörg Hanrieder et al.   ACS Chemical Neuroscience

MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney

(2014) Ove J. R. Gustafsson et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Localization and in Situ Absolute Quantification of Chlordecone in the Mouse Liver by MALDI Imaging

(2014) Mélanie Lagarrigue et al.   ANALYTICAL CHEMISTRY

Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

(2014) Oskar Karlsson et al.   ARCHIVES OF TOXICOLOGY

30μm spatial resolution protein MALDI MSI: In-depth comparison of five sample preparation protocols applied to human healthy and atherosclerotic arteries

(2014) Marta Martin-Lorenzo et al.   Journal of Proteomics

Probing the lipid chemistry of neurotoxin-induced hippocampal lesions using multimodal imaging mass spectrometry

(2014) Jörg Hanrieder et al.   SURFACE AND INTERFACE ANALYSIS

Quantitative whole-body autoradiography, LC–MS/MS and MALDI for drug-distribution studies in biological samples: the ultimate matrix trilogy

(2014) Andrew B McEwen et al.   Bioanalysis

Label-free MS imaging from drug discovery to preclinical development

(2014) Guillaume Hochart et al.   Bioanalysis

A Mimetic Tissue Model for the Quantification of Drug Distributions by MALDI Imaging Mass Spectrometry

(2013) M. Reid Groseclose et al.   ANALYTICAL CHEMISTRY

Drug safety testing paradigm, current progress and future challenges: an overview

(2013) Varun Ahuja et al.   JOURNAL OF APPLIED TOXICOLOGY

Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats

(2013) Oskar Karlsson et al.   JOURNAL OF PROTEOME RESEARCH

Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice: lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry

(2013) Sayoko Onishi et al.   Medical Molecular Morphology

Quality Measures of Imaging Mass Spectrometry Aids in Revealing Long-term Striatal Protein Changes Induced by Neonatal Exposure to the Cyanobacterial Toxin β-N-methylamino-L-alanine (BMAA)

(2013) Oskar Karlsson et al.   MOLECULAR & CELLULAR PROTEOMICS

MALDI Mass Spectrometry Imaging of 1-Methyl-4-phenylpyridinium (MPP+) in Mouse Brain

(2013) Hanane Kadar et al.   NEUROTOXICITY RESEARCH

Maternal Transfer of the Cyanobacterial Neurotoxin β-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring

(2013) Marie Andersson et al.   PLoS One

Quantitative imaging of a therapeutic peptide in biological tissue sections by MALDI MS

(2013) Nozomi Takai et al.   Bioanalysis

Controlled-pH Tissue Cleanup Protocol for Signal Enhancement of Small Molecule Drugs Analyzed by MALDI-MS Imaging

(2012) Mohammadreza Shariatgorji et al.   ANALYTICAL CHEMISTRY

Deuterated Matrix-Assisted Laser Desorption Ionization Matrix Uncovers Masked Mass Spectrometry Imaging Signals of Small Molecules

(2012) Mohammadreza Shariatgorji et al.   ANALYTICAL CHEMISTRY

Multivariate Analysis of ToF-SIMS Data from Multicomponent Systems: The Why, When, and How

(2012) Daniel J. Graham et al.   Biointerphases

MALDI imaging of post-mortem human spinal cord in amyotrophic lateral sclerosis

(2012) Jörg Hanrieder et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor

(2012) Gregory Hamm et al.   Journal of Proteomics

Novel mass spectrometry imaging software assisting labeled normalization and quantitation of drugs and neuropeptides directly in tissue sections

(2012) Patrik Källback et al.   Journal of Proteomics

In Situ Mass Spectrometry Imaging and Ex Vivo Characterization of Renal Crystalline Deposits Induced in Multiple Preclinical Drug Toxicology Studies

(2012) Anna Nilsson et al.   PLoS One

MALDI MS imaging as a powerful tool for investigating synovial tissue

(2012) M Kriegsmann et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus

(2012) Oskar Karlsson et al.   TOXICOLOGICAL SCIENCES

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease

(2012) Jörg Hanrieder et al.   Jove-Journal of Visualized Experiments

Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

(2011) Julia Laskin et al.   ANALYTICAL CHEMISTRY

Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period

(2011) Oskar Karlsson et al.   BEHAVIOURAL BRAIN RESEARCH

Drug and metabolite concentrations in tissues in relationship to tissue adverse findings: a review

(2011) Mario Pellegatti et al.   Expert Opinion on Drug Metabolism & Toxicology

l-DOPA-induced Dyskinesia is Associated with Regional Increase of Striatal Dynorphin Peptides as Elucidated by Imaging Mass Spectrometry

(2011) Jörg Hanrieder et al.   MOLECULAR & CELLULAR PROTEOMICS

Multiple Statistical Analysis Techniques Corroborate Intratumor Heterogeneity in Imaging Mass Spectrometry Datasets of Myxofibrosarcoma

(2011) Emrys A. Jones et al.   PLoS One

Imaging Mass Spectrometry Reveals Elevated Nigral Levels of Dynorphin Neuropeptides in L-DOPA-Induced Dyskinesia in Rat Model of Parkinson's Disease

(2011) Anna Ljungdahl et al.   PLoS One

A quantitation method for mass spectrometry imaging

(2011) Stormy L. Koeniger et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

MALDI imaging mass spectrometry: bridging biology and chemistry in drug development

(2011) Stephen Castellino et al.   Bioanalysis

Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumour type and grade, and reveals biochemical intratumour heterogeneity

(2010) Stefan M Willems et al.   JOURNAL OF PATHOLOGY

Molecular Analysis of Tumor Margins by MALDI Mass Spectrometry in Renal Carcinoma

(2010) Stacey R. Oppenheimer et al.   JOURNAL OF PROTEOME RESEARCH

MALDI Imaging Mass Spectrometry - Painting Molecular Pictures

(2010) Kristina Schwamborn et al.   Molecular Oncology

Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry

(2010) Anna Nilsson et al.   PLoS One

Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development

(2009) Eric G. Solon et al.   AAPS Journal

Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF–SIMS

(2009) Farida Benabdellah et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation

(2009) Kristin E. Burnum et al.   JOURNAL OF LIPID RESEARCH

Matrix-assisted laser desorption/ionization tissue profiling of secretoneurin in the nucleus accumbens shell from cocaine-sensitized rats

(2009) Joachim D. Uys et al.   JOURNAL OF MASS SPECTROMETRY

Imaging Mass Spectrometry for Visualization of Drug and Endogenous Metabolite Distribution: Toward In Situ Pharmacometabolomes

(2009) Yuki Sugiura et al.   Journal of Neuroimmune Pharmacology

Striatal Alterations of Secretogranin-1, Somatostatin, Prodynorphin, and Cholecystokinin Peptides in an Experimental Mouse Model of Parkinson Disease

(2009) Anna Nilsson et al.   MOLECULAR & CELLULAR PROTEOMICS

A comparison of PCA and MAF for ToF-SIMS image interpretation

(2009) Alex Henderson et al.   SURFACE AND INTERFACE ANALYSIS

Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents

(2009) Oskar Karlsson et al.   TOXICOLOGICAL SCIENCES

Long-term Cognitive Impairments in Adult Rats Treated Neonatally with β-N-Methylamino-L-Alanine

(2009) Oskar Karlsson et al.   TOXICOLOGICAL SCIENCES

MALDI Imaging Combined with Hierarchical Clustering as a New Tool for the Interpretation of Complex Human Cancers

(2008) Sören-Oliver Deininger et al.   JOURNAL OF PROTEOME RESEARCH

MALDI Imaging of Formalin-Fixed Paraffin-Embedded Tissues: Application to Model Animals of Parkinson Disease for Biomarker Hunting

(2008) J. Stauber et al.   JOURNAL OF PROTEOME RESEARCH

Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections

(2008) Erin H. Seeley et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Time-dependent evolution of tissue markers by MALDI-MS imaging

(2008) Richard J. A. Goodwin et al.   PROTEOMICS