Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis

(2014) R. C. Hartkoorn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection

(2014) C. Trujillo et al.   mBio

Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

(2014) Susan Puckett et al.   PLoS Pathogens

Feast or famine: the host-pathogen battle over amino acids

(2013) Yanjia J. Zhang et al.   CELLULAR MICROBIOLOGY

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism

(2013) Subhalaxmi Nambi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversible acetylation regulates acetate and propionate metabolism in Mycobacterium smegmatis

(2013) J. D. Hayden et al.   MICROBIOLOGY-SGM

Regulation of the KstR2 regulon ofMycobacterium tuberculosisby a cholesterol catabolite

(2013) Israël Casabon et al.   MOLECULAR MICROBIOLOGY

Exploring the Mode of Action of Bioactive Compounds by Microfluidic Transcriptional Profiling in Mycobacteria

(2013) Paul Murima et al.   PLoS One

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

Cyclic AMP-induced Conformational Changes in Mycobacterial Protein Acetyltransferases

(2012) Subhalaxmi Nambi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis

(2012) Ho Jun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Novel Role of the PrpR as a Transcription Factor Involved in the Regulation of Methylcitrate Pathway in Mycobacterium tuberculosis

(2012) Paweł Masiewicz et al.   PLoS One

Linking the Transcriptional Profiles and the Physiological States of Mycobacterium tuberculosis during an Extended Intracellular Infection

(2012) Kyle H. Rohde et al.   PLoS Pathogens

Reversible Acetylation and Inactivation ofMycobacterium tuberculosisAcetyl-CoA Synthetase Is Dependent on cAMP

(2011) Hua Xu et al.   BIOCHEMISTRY

Activity of 3-Ketosteroid 9α-Hydroxylase (KshAB) Indicates Cholesterol Side Chain and Ring Degradation Occur Simultaneously inMycobacterium tuberculosis

(2011) Jenna K. Capyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

A Flavin-dependent Monooxygenase fromMycobacterium tuberculosisInvolved in Cholesterol Catabolism

(2010) Carola Dresen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberculosis: What We Don't Know Can, and Does, Hurt Us

(2010) D. G. Russell et al.   SCIENCE

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

Functional Genetic Diversity among Mycobacterium tuberculosis Complex Clinical Isolates: Delineation of Conserved Core and Lineage-Specific Transcriptomes during Intracellular Survival

(2010) Susanne Homolka et al.   PLoS Pathogens

Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism

(2009) Nathan A. Lack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3-Ketosteroid 9α-hydroxylase is an essential factor in the pathogenesis ofMycobacterium tuberculosis

(2009) Yanmin Hu et al.   MOLECULAR MICROBIOLOGY

Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

(2009) Katherine C. Yam et al.   PLoS Pathogens

Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response

(2009) Amit Singh et al.   PLoS Pathogens

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide

(2008) Philip D. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5–MmpL5 efflux system

(2008) Anna Milano et al.   TUBERCULOSIS