Protein–Protein Interactions with Connexin 43: Regulation and Function

The connexin 43 C-terminus: A tail of many tales

(2018) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics

(2018) Joell L. Solan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43

(2018) Jian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions

(2017) Max Z. Totland et al.   JOURNAL OF CELL SCIENCE

Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover

(2017) Anastasia F. Thévenin et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions

(2016) Matthias M. Falk et al.   BMC CELL BIOLOGY

Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2

(2016) Hanjun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Studies of the Nedd4 WW Domains and Their Selectivity for the Connexin43 (Cx43) Carboxyl Terminus

(2016) Gaelle Spagnol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New protein-protein interactions of mitochondrial connexin 43 in mouse heart

(2016) Amanda Denuc et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1

(2016) Cinzia Ambrosi et al.   PLoS One

The cardiac connexome: Non-canonical functions of connexin43 and their role in cardiac arrhythmias

(2016) Alejandra Leo-Macias et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells

(2016) Xiaoxuan Chen et al.   Scientific Reports

Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75)

(2015) Jennifer L. Kopanic et al.   BIOCHEMICAL JOURNAL

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

(2015) Tania Martins-Marques et al.   BIOCHEMICAL JOURNAL

Gap junctions–guards of excitability

(2015) Line Waring Stroemlund et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs

(2015) Tânia Martins-Marques et al.   BIOCHIMIE

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis

(2015) Wassim A. Basheer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart

(2015) Tania Martins-Marques et al.   MOLECULAR & CELLULAR PROTEOMICS

Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization

(2015) Wutigri Nimlamool et al.   MOLECULAR BIOLOGY OF THE CELL

Rapid electrical stimulation causes alterations in cardiac intercellular junction proteins of cardiomyocytes

(2014) Tadamitsu Nakashima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc

(2014) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

Trafficking Highways to the Intercalated Disc: New Insights Unlocking the Specificity of Connexin 43 Localization

(2014) Shan-Shan Zhang et al.   CELL COMMUNICATION AND ADHESION

Osteoblastic protein tyrosine phosphatases inhibition and connexin 43 phosphorylation by alendronate

(2014) V. Lezcano et al.   EXPERIMENTAL CELL RESEARCH

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

(2014) Teresa M. Ribeiro-Rodrigues et al.   FASEB JOURNAL

Gap junction regulation by calmodulin

(2014) Juan Zou et al.   FEBS LETTERS

EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368

(2014) John T. Fong et al.   FEBS LETTERS

Arrhythmogenic cardiomyopathy and Brugada syndrome: Diseases of the connexome

(2014) Esperanza Agullo-Pascual et al.   FEBS LETTERS

Protein Kinase Cδ-mediated Phosphorylation of Connexin43 Gap Junction Channels Causes Movement within Gap Junctions followed by Vesicle Internalization and Protein Degradation

(2014) Angela C. Cone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication

(2014) Hanjun Li et al.   JOURNAL OF CELL SCIENCE

A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion

(2014) G. Pidoux et al.   JOURNAL OF CELL SCIENCE

Connexins modulate autophagosome biogenesis

(2014) Eloy Bejarano et al.   NATURE CELL BIOLOGY

Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic

(2014) T. Kirchhausen et al.   Cold Spring Harbor Perspectives in Biology

Cross-regulation of Connexin43 and β-catenin influences differentiation of human neural progenitor cells

(2014) F Rinaldi et al.   Cell Death & Disease

Carboxy terminus and pore-forming domain properties specific to Cx37 are necessary for Cx37-mediated suppression of insulinoma cell proliferation

(2013) Tasha K. Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

(2013) Indra Lübkemeier et al.   BASIC RESEARCH IN CARDIOLOGY

CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43

(2013) Vivian Su et al.   BIOCHEMICAL JOURNAL

The Canonical WNT2 Pathway and FSH Interact to Regulate Gap Junction Assembly in Mouse Granulosa Cells1

(2013) Hong-Xing Wang et al.   BIOLOGY OF REPRODUCTION

Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque

(2013) Esperanza Agullo-Pascual et al.   CARDIOVASCULAR RESEARCH

Stochastic machines as a colocalization mechanism for scaffold protein function

(2013) Bin Xue et al.   FEBS LETTERS

Effects of Phosphorylation on the Structure and Backbone Dynamics of the Intrinsically Disordered Connexin43 C-terminal Domain

(2013) Rosslyn Grosely et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3  facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels

(2013) N. Batra et al.   JOURNAL OF CELL SCIENCE

Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

(2013) C. A. Dunn et al.   JOURNAL OF CELL SCIENCE

Hypoxia induces connexin 43 dysregulation by modulating matrix metalloproteinases via MAPK signaling

(2013) Xianghong Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells

(2013) Kristen E. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis

(2013) John T. Fong et al.   MOLECULAR BIOLOGY OF THE CELL

Proteins and Mechanisms Regulating Gap-Junction Assembly, Internalization, and Degradation

(2013) Anastasia F. Thévenin et al.   PHYSIOLOGY

Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 70

(2013) Tomoya Hatakeyama et al.   Scientific Reports

Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms

(2013) James W. Smyth et al.   Cell Reports

Managing the complexity of communication: regulation of gap junctions by post-translational modification

(2013) Lene N. Axelsen et al.   Frontiers in Pharmacology

A functional interaction between the MAGUK protein hDlg and the gap junction protein connexin 43 in cervical tumour cells

(2012) Alasdair I. MacDonald et al.   BIOCHEMICAL JOURNAL

Phosphorylation Controls the Interaction of the Connexin43 C-Terminal Domain with Tubulin and Microtubules

(2012) Amal Saidi Brikci-Nigassa et al.   BIOCHEMISTRY

Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current

(2012) Thomas Desplantez et al.   CARDIOVASCULAR RESEARCH

MAPK Phosphorylation of Connexin 43 Promotes Binding of Cyclin E and Smooth Muscle Cell Proliferation

(2012) Scott R. Johnstone et al.   CIRCULATION RESEARCH

Molecular connexin partner remodeling orchestrates connexin traffic: From physiology to pathophysiology

(2012) Jérôme Gilleron et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Connexin 43 interacts with Bax to regulate apoptosis of pancreatic cancer through a gap junction-independent pathway

(2012) YAN SUN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Characterization of the Structure and Intermolecular Interactions between the Connexin 32 Carboxyl-terminal Domain and the Protein Partners Synapse-associated Protein 97 and Calmodulin

(2012) Kelly Stauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43

(2012) Tone Aase Fykerud et al.   JOURNAL OF CELL SCIENCE

CASK (LIN2) interacts with Cx43 in wounded skin and their coexpression affects cell migration

(2012) L. Marquez-Rosado et al.   JOURNAL OF CELL SCIENCE

Coregulation of Multiple Signaling Mechanisms in pp60v-Src-Induced Closure of Cx43 Gap Junction Channels

(2012) Siddhartha S. Mitra et al.   JOURNAL OF MEMBRANE BIOLOGY

The Noncanonical Functions of Cx43 in the Heart

(2012) Esperanza Agullo-Pascual et al.   JOURNAL OF MEMBRANE BIOLOGY

Association of Connexin43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control

(2012) Vincent C. Chen et al.   JOURNAL OF PROTEOME RESEARCH

Loss of Cadherin-Binding Proteins  -Catenin and Plakoglobin in the Heart Leads to Gap Junction Remodeling and Arrhythmogenesis

(2012) D. Swope et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

(2012) Eloy Bejarano et al.   MOLECULAR BIOLOGY OF THE CELL

Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions

(2011) Sarah Mollerup et al.   CELL COMMUNICATION AND ADHESION

Phosphatase-Resistant Gap Junctions Inhibit Pathological Remodeling and Prevent Arrhythmias

(2011) Benjamin F. Remo et al.   CIRCULATION RESEARCH

Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc

(2011) Priscila Y. Sato et al.   CIRCULATION RESEARCH

Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage

(2011) Renu A. Kowluru et al.   DIABETES

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

(2011) Katja Gehmlich et al.   HEART RHYTHM

Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice

(2011) John A. Jansen et al.   HEART RHYTHM

The perinexus: A new feature of Cx43 gap junction organization

(2011) Joshua Matthew Rhett et al.   HEART RHYTHM

The large GTPase dynamin2: A new player in connexin 43 gap junction endocytosis, recycling and degradation

(2011) Jérôme Gilleron et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of Akt, Not Connexin 43 Protein Ubiquitination, Regulates Gap Junction Stability

(2011) Clarence A. Dunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin43 interacts with βarrestin: A pre-requisite for osteoblast survival induced by parathyroid hormone

(2011) Nicoletta Bivi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

(2011) J. Matthew Rhett et al.   MOLECULAR BIOLOGY OF THE CELL

The identification of novel protein, brain-derived integrating factor-1 (BDIF1), which interacts with astrocytic gap junctional protein

(2011) Takeshi Ito et al.   NEUROSCIENCE RESEARCH

Connexin43 Modulates Cell Polarity and Directional Cell Migration by Regulating Microtubule Dynamics

(2011) Richard Francis et al.   PLoS One

Ubiquitin-independent Proteasomal Degradation of Endoplasmic Reticulum-localized Connexin43 Mediated by CIP75

(2010) Vivian Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR structure note: UBA domain of CIP75

(2010) Fabien Kieken et al.   JOURNAL OF BIOMOLECULAR NMR

Microtubule +TIPs at a glance

(2010) A. Akhmanova et al.   JOURNAL OF CELL SCIENCE

Identification of CaMKII Phosphorylation Sites in Connexin43 by High-Resolution Mass Spectrometry

(2010) Richard Y−C. Huang et al.   JOURNAL OF PROTEOME RESEARCH

Trafficking and Recycling of the Connexin43 Gap Junction Protein during Mitosis

(2010) Daniela Boassa et al.   TRAFFIC

Connexin43 phosphorylation: structural changes and biological effects

(2009) Joell L. Solan et al.   BIOCHEMICAL JOURNAL

Connexins: a myriad of functions extending beyond assembly of gap junction channels

(2009) Hashem A Dbouk et al.   Cell Communication and Signaling

Structural and Molecular Mechanisms of Gap Junction Remodeling in Epicardial Border Zone Myocytes following Myocardial Infarction

(2009) Fabien Kieken et al.   CIRCULATION RESEARCH

The TSG101 protein binds to connexins and is involved in connexin degradation

(2009) Tanja Auth et al.   EXPERIMENTAL CELL RESEARCH

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

(2009) Henrique Girão et al.   EXPERIMENTAL CELL RESEARCH

Phosphorylation of connexin43 on serine 306 regulates electrical coupling

(2009) Kristina Procida et al.   HEART RHYTHM

Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins

(2009) Francisco J. del Castillo et al.   HUMAN MOLECULAR GENETICS

Activator of G Protein Signaling 8 (AGS8) Is Required for Hypoxia-induced Apoptosis of Cardiomyocytes

(2009) Motohiko Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101

(2009) E. Leithe et al.   JOURNAL OF CELL SCIENCE

ERp29 Restricts Connexin43 Oligomerization in the Endoplasmic Reticulum

(2009) Shamie Das et al.   MOLECULAR BIOLOGY OF THE CELL

Connexin43 interacts with Caveolin-3 in the heart

(2009) Limei Liu et al.   MOLECULAR BIOLOGY REPORTS

Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics

(2009) M. W. M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gap junction proteome and its relationship to disease

(2009) Dale W. Laird   TRENDS IN CELL BIOLOGY

Structural Changes in the Carboxyl Terminus of the Gap Junction Protein Connexin40 Caused by the Interaction with c-Src and Zonula Occludens-1

(2008) Denis Bouvier et al.   CELL COMMUNICATION AND ADHESION

Connexin43 in LA-25 Cells with Active v-src Is Phosphorylated on Y247, Y265, S262, S279/282, and S368 via Multiple Signaling Pathways

(2008) Joell L. Solan et al.   CELL COMMUNICATION AND ADHESION

Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen

(2008) J. Gilleron et al.   JOURNAL OF CELL SCIENCE

Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes

(2008) Johannes P. Hofgaard et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor  2 subunit

(2008) J. T. Kittler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caveolin-1 and -2 Interact with Connexin43 and Regulate Gap Junctional Intercellular Communication in Keratinocytes

(2007) Stéphanie Langlois et al.   MOLECULAR BIOLOGY OF THE CELL