Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions

Structural Studies of the Nedd4 WW Domains and Their Selectivity for the Connexin43 (Cx43) Carboxyl Terminus

(2016) Gaelle Spagnol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair

(2016) Joell L. Solan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes

(2015) Tania Martins-Marques et al.   BIOCHEMICAL JOURNAL

Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive: Figure 1

(2015) Teresa M. Ribeiro-Rodrigues et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

New cellular mechanisms of gap junction degradation and recycling

(2015) Diane Carette et al.   BIOLOGY OF THE CELL

Autophagy and Ubiquitination in Cardiovascular Diseases

(2015) Tania Martins-Marques et al.   DNA AND CELL BIOLOGY

Connexin Type and Fluorescent Protein Fusion Tag Determine Structural Stability of Gap Junction Plaques

(2015) Randy F. Stout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-color fluorescent analysis of connexin 36 turnover: relationship to functional plasticity

(2015) H. Y. Wang et al.   JOURNAL OF CELL SCIENCE

The functional and pathologic relevance of autophagy proteases

(2015) Álvaro F. Fernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis

(2015) Wassim A. Basheer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization

(2015) Wutigri Nimlamool et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms linking connexin mutations to human diseases

(2014) John J. Kelly et al.   CELL AND TISSUE RESEARCH

Mutation of Human Connexin43 Amino Acids S279/S282 Increases Protein Stability Upon Treatment with Epidermal Growth Factor

(2014) Melanie Schmitt et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

(2014) Teresa M. Ribeiro-Rodrigues et al.   FASEB JOURNAL

Specific Cx43 phosphorylation events regulate gap junction turnover in vivo

(2014) Joell L. Solan et al.   FEBS LETTERS

Cardiac to cancer: Connecting connexins to clinical opportunity

(2014) Christina L. Grek et al.   FEBS LETTERS

Syndromic and non-syndromic disease-linked Cx43 mutations

(2014) Dale W. Laird   FEBS LETTERS

Degradation of connexins and gap junctions

(2014) Matthias M. Falk et al.   FEBS LETTERS

EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368

(2014) John T. Fong et al.   FEBS LETTERS

Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation

(2014) Dingzhang Xiao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein Kinase Cδ-mediated Phosphorylation of Connexin43 Gap Junction Channels Causes Movement within Gap Junctions followed by Vesicle Internalization and Protein Degradation

(2014) Angela C. Cone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated

(2014) Joanna Gemel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Connexin50 Mutant, CX50fs, That Causes Cataracts Is Unstable, but Is Rescued by a Proteasomal Inhibitor

(2013) Peter J. Minogue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing the effect of dynamin inhibition on annular gap vesicle formation and fission

(2013) B. Nickel et al.   JOURNAL OF CELL SCIENCE

Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

(2013) C. A. Dunn et al.   JOURNAL OF CELL SCIENCE

Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells

(2013) Kristen E. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis

(2013) John T. Fong et al.   MOLECULAR BIOLOGY OF THE CELL

Proteins and Mechanisms Regulating Gap-Junction Assembly, Internalization, and Degradation

(2013) Anastasia F. Thévenin et al.   PHYSIOLOGY

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Ubiquitination, intracellular trafficking, and degradation of connexins

(2012) Vivian Su et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Internalized gap junctions are degraded by autophagy

(2012) John T. Fong et al.   Autophagy

Connexins in atherosclerosis

(2012) Anna Pfenniger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

How do mutations in GJB1 cause X-linked Charcot–Marie–Tooth disease?

(2012) Kleopas A. Kleopa et al.   BRAIN RESEARCH

The Gap Junction Channel Protein Connexin 43 Is Covalently Modified and Regulated by SUMOylation

(2012) Ane Kjenseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Modulation of Drp1 Mechanoenzyme Assembly and Mitochondrial Fission by the Variable Domain

(2012) Stefan Strack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43

(2012) Tone Aase Fykerud et al.   JOURNAL OF CELL SCIENCE

RETRACTED ARTICLE: Electrical Transmission between Mammalian Neurons is Supported by a Small Fraction of Gap Junction Channels

(2012) Sebastian Curti et al.   JOURNAL OF MEMBRANE BIOLOGY

Degradation of Endocytosed Gap Junctions by Autophagosomal and Endo-/lysosomal Pathways: A Perspective

(2012) Matthias M. Falk et al.   JOURNAL OF MEMBRANE BIOLOGY

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

(2012) Eloy Bejarano et al.   MOLECULAR BIOLOGY OF THE CELL

Trafficking of gap junction channels at a vertebrate electrical synapse in vivo

(2012) C. E. Flores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal

(2011) Steve Catarino et al.   BIOCHEMICAL JOURNAL

Endocytosis and post-endocytic sorting of connexins

(2011) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Gap junctions in inherited human disorders of the central nervous system

(2011) Charles K. Abrams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Gap junctional channels are parts of multiprotein complexes

(2011) Jean-Claude Hervé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The large GTPase dynamin2: A new player in connexin 43 gap junction endocytosis, recycling and degradation

(2011) Jérôme Gilleron et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy: a pathway that contributes to connexin degradation

(2011) A. Lichtenstein et al.   JOURNAL OF CELL SCIENCE

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

(2011) J. Matthew Rhett et al.   MOLECULAR BIOLOGY OF THE CELL

Gap junction assembly: roles for the formation plaque and regulation by the C-terminus of connexin43

(2011) Ross G. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of gap junction intercellular communication by the ubiquitin system

(2010) Ane Kjenseth et al.   CELLULAR SIGNALLING

Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart

(2010) Geoffrey G. Hesketh et al.   CIRCULATION RESEARCH

Mitochondrial fission and fusion

(2010) Iain Scott et al.   Essays in Biochemistry

Novel connexin40 missense mutations in patients with familial atrial fibrillation

(2010) Y.-Q. Yang et al.   EUROPACE

Trafficking and Recycling of the Connexin43 Gap Junction Protein during Mitosis

(2010) Daniela Boassa et al.   TRAFFIC

Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication

(2009) Solveig Sirnes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

(2009) Henrique Girão et al.   EXPERIMENTAL CELL RESEARCH

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101

(2009) E. Leithe et al.   JOURNAL OF CELL SCIENCE

Gap Junction Turnover Is Achieved by the Internalization of Small Endocytic Double-Membrane Vesicles

(2009) Matthias M. Falk et al.   MOLECULAR BIOLOGY OF THE CELL

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Structure of the connexin 26 gap junction channel at 3.5 Å resolution

(2009) Shoji Maeda et al.   NATURE

Clathrin and Cx43 gap junction plaque endoexocytosis

(2008) Beth M. Nickel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Long and Short of Membrane Fission

(2008) Aurélien Roux et al.   CELL

Migrating Cells Retain Gap Junction Plaque Structure and Function

(2008) Bado Hewa Defranco et al.   CELL COMMUNICATION AND ADHESION

Connexin43 in LA-25 Cells with Active v-src Is Phosphorylated on Y247, Y265, S262, S279/282, and S368 via Multiple Signaling Pathways

(2008) Joell L. Solan et al.   CELL COMMUNICATION AND ADHESION

Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival

(2008) M. J. Laws et al.   DEVELOPMENT

Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites

(2008) Jia Chen et al.   EMBO JOURNAL

Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation

(2008) Susan M. Baker et al.   FEBS LETTERS

Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery

(2008) Anna M. Gumpert et al.   FEBS LETTERS

Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen

(2008) J. Gilleron et al.   JOURNAL OF CELL SCIENCE

Dynamics of Dynamin during Clathrin Mediated Endocytosis in PC12 Cells

(2008) Joshua Z. Rappoport et al.   PLoS One

Accelerated internalization of junctional membrane proteins (connexin 43, N-cadherin and ZO-1) within endocytic vacuoles: An early event of DDT carcinogenicity

(2007) Céline Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES