Proteins and Mechanisms Regulating Gap-Junction Assembly, Internalization, and Degradation

Structural studies of N-terminal mutants of Connexin 32 using 1H NMR spectroscopy

(2012) B.D. Kalmatsky et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ubiquitination, intracellular trafficking, and degradation of connexins

(2012) Vivian Su et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Internalized gap junctions are degraded by autophagy

(2012) John T. Fong et al.   Autophagy

The role of the Cx43 C-terminus in GJ plaque formation and internalization

(2012) Praween Wayakanon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation Controls the Interaction of the Connexin43 C-Terminal Domain with Tubulin and Microtubules

(2012) Amal Saidi Brikci-Nigassa et al.   BIOCHEMISTRY

The Gap Junction Channel Protein Connexin 43 Is Covalently Modified and Regulated by SUMOylation

(2012) Ane Kjenseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43

(2012) Tone Aase Fykerud et al.   JOURNAL OF CELL SCIENCE

RETRACTED ARTICLE: Electrical Transmission between Mammalian Neurons is Supported by a Small Fraction of Gap Junction Channels

(2012) Sebastian Curti et al.   JOURNAL OF MEMBRANE BIOLOGY

The N-Terminal Half of the Connexin Protein Contains the Core Elements of the Pore and Voltage Gates

(2012) Jack Kronengold et al.   JOURNAL OF MEMBRANE BIOLOGY

Degradation of Connexins Through the Proteasomal, Endolysosomal and Phagolysosomal Pathways

(2012) Vivian Su et al.   JOURNAL OF MEMBRANE BIOLOGY

Posttranslational Modifications in Connexins and Pannexins

(2012) Scott R. Johnstone et al.   JOURNAL OF MEMBRANE BIOLOGY

Under Construction: Building the Macromolecular Superstructure and Signaling Components of an Electrical Synapse

(2012) B. D. Lynn et al.   JOURNAL OF MEMBRANE BIOLOGY

Degradation of Endocytosed Gap Junctions by Autophagosomal and Endo-/lysosomal Pathways: A Perspective

(2012) Matthias M. Falk et al.   JOURNAL OF MEMBRANE BIOLOGY

Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

(2012) Oscar Jara et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

(2012) Eloy Bejarano et al.   MOLECULAR BIOLOGY OF THE CELL

Trafficking of gap junction channels at a vertebrate electrical synapse in vivo

(2012) C. E. Flores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal

(2011) Steve Catarino et al.   BIOCHEMICAL JOURNAL

Endocytosis and post-endocytic sorting of connexins

(2011) Edward Leithe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Gap junctional channels are parts of multiprotein complexes

(2011) Jean-Claude Hervé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The large GTPase dynamin2: A new player in connexin 43 gap junction endocytosis, recycling and degradation

(2011) Jérôme Gilleron et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of Akt, Not Connexin 43 Protein Ubiquitination, Regulates Gap Junction Stability

(2011) Clarence A. Dunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: a pathway that contributes to connexin degradation

(2011) A. Lichtenstein et al.   JOURNAL OF CELL SCIENCE

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels

(2011) Zhifang Chai et al.   MOLECULAR BIOLOGY OF THE CELL

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

(2011) J. Matthew Rhett et al.   MOLECULAR BIOLOGY OF THE CELL

Gap junction assembly: roles for the formation plaque and regulation by the C-terminus of connexin43

(2011) Ross G. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones

(2011) Lynn Bedford et al.   NEUROSCIENCE LETTERS

Membrane Proteins as 14-3-3 Clients in Functional Regulation and Intracellular Transport

(2011) Andrew J. Smith et al.   PHYSIOLOGY

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Regulation of gap junction intercellular communication by the ubiquitin system

(2010) Ane Kjenseth et al.   CELLULAR SIGNALLING

Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart

(2010) Geoffrey G. Hesketh et al.   CIRCULATION RESEARCH

Sent to Destroy

(2010) Monte S. Willis et al.   CIRCULATION RESEARCH

E-cadherin Differentially Regulates the Assembly of Connexin43 and Connexin32 into Gap Junctions in Human Squamous Carcinoma Cells

(2010) Souvik Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-independent Proteasomal Degradation of Endoplasmic Reticulum-localized Connexin43 Mediated by CIP75

(2010) Vivian Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dual Role of Zonula Occludens (ZO) Proteins

(2010) H. Bauer et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Structural studies of the N-terminus of Connexin 32 using 1H NMR spectroscopy

(2009) B.D. Kalmatsky et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Autophagy protects neuron from Aβ-induced cytotoxicity

(2009) Shih-Ya Hung et al.   Autophagy

Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication

(2009) Solveig Sirnes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Connexin43 phosphorylation: structural changes and biological effects

(2009) Joell L. Solan et al.   BIOCHEMICAL JOURNAL

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

The TSG101 protein binds to connexins and is involved in connexin degradation

(2009) Tanja Auth et al.   EXPERIMENTAL CELL RESEARCH

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

(2009) Henrique Girão et al.   EXPERIMENTAL CELL RESEARCH

The role of the cytoskeleton in the formation of gap junctions by Connexin 30

(2009) Chunyan Qu et al.   EXPERIMENTAL CELL RESEARCH

Involvement of the Interaction of Afadin with ZO-1 in the Formation of Tight Junctions in Madin-Darby Canine Kidney Cells

(2009) Takako Ooshio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101

(2009) E. Leithe et al.   JOURNAL OF CELL SCIENCE

Gap Junction Turnover Is Achieved by the Internalization of Small Endocytic Double-Membrane Vesicles

(2009) Matthias M. Falk et al.   MOLECULAR BIOLOGY OF THE CELL

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Structure of the connexin 26 gap junction channel at 3.5 Å resolution

(2009) Shoji Maeda et al.   NATURE

Connexin 33 Impairs Gap Junction Functionality by Accelerating Connexin 43 Gap Junction Plaque Endocytosis

(2009) Diane Carette et al.   TRAFFIC

Structural Changes in the Carboxyl Terminus of the Gap Junction Protein Connexin40 Caused by the Interaction with c-Src and Zonula Occludens-1

(2008) Denis Bouvier et al.   CELL COMMUNICATION AND ADHESION

Connexin43 in LA-25 Cells with Active v-src Is Phosphorylated on Y247, Y265, S262, S279/282, and S368 via Multiple Signaling Pathways

(2008) Joell L. Solan et al.   CELL COMMUNICATION AND ADHESION

Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites

(2008) Jia Chen et al.   EMBO JOURNAL

Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation

(2008) Susan M. Baker et al.   FEBS LETTERS

Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery

(2008) Anna M. Gumpert et al.   FEBS LETTERS

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

(2008) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen

(2008) J. Gilleron et al.   JOURNAL OF CELL SCIENCE

Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannel

(2008) Seunghoon Oh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

(2008) Christian Pohl et al.   NATURE CELL BIOLOGY

Accelerated internalization of junctional membrane proteins (connexin 43, N-cadherin and ZO-1) within endocytic vacuoles: An early event of DDT carcinogenicity

(2007) Céline Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES