Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

(2018) Valerio Chiurchiù et al.   Frontiers in Immunology

Pulmonary sarcoidosis is associated with exosomal vitamin D–binding protein and inflammatory molecules

(2017) Maria-Jose Martinez-Bravo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

(2017) Charles N. Serhan   MOLECULAR ASPECTS OF MEDICINE

Actors and Factors in the Resolution of Intestinal Inflammation: Lipid Mediators As a New Approach to Therapy in Inflammatory Bowel Diseases

(2017) Federica Ungaro et al.   Frontiers in Immunology

Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile

(2017) Sandra Buratta et al.   PLoS One

Bioactive lipids as modulators of immunity, inflammation and emotions

(2016) Valerio Chiurchiù et al.   CURRENT OPINION IN PHARMACOLOGY

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

(2016) Chiara Ciardiello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular RNAs: A Secret Arm of Immune System Regulation

(2016) Paola de Candia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells

(2016) Susanna A. Jethwa et al.   JOURNAL OF CELL SCIENCE

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4to leukotriene D4

(2016) Ana Lukic et al.   JOURNAL OF LIPID RESEARCH

Implications of the endogenous PPAR-gamma ligand, 15-deoxy-delta-12, 14-prostaglandin J2, in diabetic retinopathy

(2016) Tapan Behl et al.   LIFE SCIENCES

Leukotriene E4elicits respiratory epithelial cell mucin release through the G-protein–coupled receptor, GPR99

(2016) Lora G. Bankova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis

(2016) Ritankar Majumdar et al.   PLOS BIOLOGY

Promising Pharmacological Directions in the World of Lysophosphatidic Acid Signaling

(2015) Nicole C. Stoddard et al.   Biomolecules & Therapeutics

Exosomes

(2015) Heinrich J. Huber et al.   CURRENT OPINION IN LIPIDOLOGY

Active endocannabinoids are secreted on extracellular membrane vesicles

(2015) M. Gabrielli et al.   EMBO REPORTS

Endocannabinoid signalling in innate and adaptive immunity

(2015) Valerio Chiurchiù et al.   IMMUNOLOGY

Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis

(2015) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid and comprehensive ‘shotgun’ lipidome profiling of colorectal cancer cell derived exosomes

(2015) Todd A. Lydic et al.   METHODS

Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation

(2015) R E Abdulnour et al.   Mucosal Immunology

Exosomes and their roles in immune regulation and cancer

(2015) David W. Greening et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis

(2015) Zhongbin Deng et al.   Nature Communications

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

(2014) Thassila Pitanga et al.   BMC CELL BIOLOGY

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exosomes and other extracellular vesicles in host-pathogen interactions

(2014) J. S. Schorey et al.   EMBO REPORTS

Lipoxin A4 Inhibits NF-κB Activation and Cell Cycle Progression in RAW264.7 Cells

(2014) Yong-Hong Huang et al.   INFLAMMATION

Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells

(2014) C. Eken et al.   JOURNAL OF IMMUNOLOGY

Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition

(2014) A. Montecalvo et al.   JOURNAL OF IMMUNOLOGY

Cytomegalovirus-Infected Human Endothelial Cells Can Stimulate Allogeneic CD4+ Memory T Cells by Releasing Antigenic Exosomes

(2014) J. D. Walker et al.   JOURNAL OF IMMUNOLOGY

The Autotaxin-LPA Axis Emerges as a Novel Regulator of Lymphocyte Homing and Inflammation

(2014) S. Knowlden et al.   JOURNAL OF IMMUNOLOGY

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Correction: A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow

(2014) João Pedro Pereira et al.   PLoS One

Regulation of T Cell Motility In Vitro and In Vivo by LPA and LPA2

(2014) Sara A. Knowlden et al.   PLoS One

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells

(2014) Anuran Chatterjee et al.   PLoS One

Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets

(2014) Annika Pienimaeki-Roemer et al.   TRANSFUSION

Antileukotriene Agents for the Treatment of Lung Disease

(2013) Jacob P. Scott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

(2013) Theresa L. Whiteside   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

(2013) Alicia Llorente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Emerging concepts on the role of exosomes in lipid metabolic diseases

(2013) Michel Record et al.   BIOCHIMIE

Exosomes derived from human macrophages suppress endothelial cell migration by controlling integrin trafficking

(2013) Hee Doo Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crystal Structures of Leukotriene C4Synthase in Complex with Product Analogs

(2013) Damian Niegowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells

(2013) Z.-B. Deng et al.   JOURNAL OF IMMUNOLOGY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Protectin DX, a Double Lipoxygenase Product of DHA, Inhibits Both ROS Production in Human Neutrophils and Cyclooxygenase Activities

(2013) Miao Liu et al.   LIPIDS

Intracellular Modulation, Extracellular Disposal and Serum Increase of MiR-150 Mark Lymphocyte Activation

(2013) Paola de Candia et al.   PLoS One

Immunomodulatory Impact of Leishmania-Induced Macrophage Exosomes: A Comparative Proteomic and Functional Analysis

(2013) Kasra Hassani et al.   PLoS Neglected Tropical Diseases

The Immunobiology of Prostanoid Receptor Signaling in Connecting Innate and Adaptive Immunity

(2013) Hedi Harizi   Biomed Research International

Lysophosphatidic Acid Inhibits CD8 T-cell Activation and Control of Tumor Progression

(2013) S. K. Oda et al.   Cancer Immunology Research

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma

(2012) P. Torregrosa Paredes et al.   ALLERGY

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Cholesterol-Induced Membrane Microvesicles As Novel Carriers of Damage–Associated Molecular Patterns

(2012) Ming-Lin Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antibacterial effect of microvesicles released from human neutrophilic granulocytes

(2012) C. I. Timar et al.   BLOOD

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis

(2012) Philippe V. Afonso et al.   DEVELOPMENTAL CELL

Intestinal mucus-derived nanoparticle-mediated activation of Wnt/β-catenin signaling plays a role in induction of liver natural killer T cell anergy in mice

(2012) Zhong-Bin Deng et al.   HEPATOLOGY

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration

(2012) S. B. Walters et al.   JOURNAL OF IMMUNOLOGY

Exosomes Isolated from Mycobacteria-Infected Mice or Cultured Macrophages Can Recruit and Activate Immune Cells In Vitro and In Vivo

(2012) P. P. Singh et al.   JOURNAL OF IMMUNOLOGY

Tolerance Induction by Exosomes from Immature Dendritic Cells and Rapamycin in a Mouse Cardiac Allograft Model

(2012) Xiao Li et al.   PLoS One

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cell synapses and exosomes: membrane contacts for information exchange

(2012) Amanda Carroll-Portillo   Frontiers in Immunology

Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands

(2012) Stephan Munich et al.   OncoImmunology

NK cell-released exosomes

(2012) Stefano Fais   OncoImmunology

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing

(2011) L. V. Norling et al.   JOURNAL OF IMMUNOLOGY

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

MHC class II-associated invariant chain (Ii) modulates dendritic cells-derived microvesicles (DCMV)-mediated activation of microglia

(2010) Boon Heng Dennis Teo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis

(2010) Paola Maderna et al.   FASEB JOURNAL

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration

(2010) Julia Esser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production

(2010) M. M. Y. Chan et al.   JOURNAL OF IMMUNOLOGY

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

(2010) Caroline Subra et al.   JOURNAL OF LIPID RESEARCH

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Exosomal Hsp70 Induces a Pro-Inflammatory Response to Foreign Particles Including Mycobacteria

(2010) Paras K. Anand et al.   PLoS One

Exosomes: immune properties and potential clinical implementations

(2010) Nathalie Chaput et al.   Seminars in Immunopathology

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

(2010) Hongbo Chi   TRENDS IN PHARMACOLOGICAL SCIENCES

P2X7 Receptor-Stimulated Secretion of MHC Class II-Containing Exosomes Requires the ASC/NLRP3 Inflammasome but Is Independent of Caspase-1

(2009) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Monocyte Derived Microvesicles Deliver a Cell Death Message via Encapsulated Caspase-1

(2009) Anasuya Sarkar et al.   PLoS One

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

(2009) S. Zarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

(2008) Takao Shimizu   Annual Review of Pharmacology and Toxicology

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

(2008) Venkateswara Rao Simhadri et al.   PLoS One