Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Autotaxin: structure-function and signaling

(2014) Anastassis Perrakis et al.   JOURNAL OF LIPID RESEARCH

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal

(2014) Andrew J. Muinonen-Martin et al.   PLOS BIOLOGY

Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration

(2013) Tao Wu et al.   FASEB JOURNAL

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins Derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes

(2012) Elham Hosseini-Beheshti et al.   MOLECULAR & CELLULAR PROTEOMICS

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Autotaxin and LPA receptor signaling in cancer

(2011) Anna J. S. Houben et al.   CANCER AND METASTASIS REVIEWS

Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells

(2011) Zachary Fulkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into autotaxin: how to produce and present a lipid mediator

(2011) Wouter H. Moolenaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of substrate discrimination and integrin binding by autotaxin

(2011) Jens Hausmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

(2011) Hiroshi Nishimasu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thematic Review Series: Glycerolipids.Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

(2008) Karen Reue et al.   JOURNAL OF LIPID RESEARCH

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE