Actors and Factors in the Resolution of Intestinal Inflammation: Lipid Mediators As a New Approach to Therapy in Inflammatory Bowel Diseases

MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice

(2017) Federica Ungaro et al.   GASTROENTEROLOGY

Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal

(2017) Islam Khan et al.   MEDICAL PRINCIPLES AND PRACTICE

Protectin D1n-3 DPAand resolvin D5n-3 DPAare effectors of intestinal protection

(2017) Thomas Gobbetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Mesenchymal Stromal Cells in Immunity

(2017) Valeria Messina et al.   Stem Cells International

A novel anti-inflammatory role of GPR120 in intestinal epithelial cells

(2016) Arivarasu N. Anbazhagan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endothelial Cell-Immune Cell Interaction in IBD

(2016) Silvio Danese et al.   DIGESTIVE DISEASES

Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages

(2016) Dong-Soon Im   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation

(2016) Masakazu Shinohara et al.   Journal of Atherosclerosis and Thrombosis

Inflammatory bowel disease as a disorder of an imbalance between pro- and anti-inflammatory molecules and deficiency of resolution bioactive lipids

(2016) Undurti N. Das   Lipids in Health and Disease

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

(2016) Jonathan Landy et al.   WORLD JOURNAL OF GASTROENTEROLOGY

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

(2016) Artemis Simopoulos   Nutrients

GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice

(2016) Jie Zhao et al.   Oncotarget

Neutrophils: Their Role in Innate and Adaptive Immunity

(2016) Carlos Rosales et al.   Journal of Immunology Research

The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions

(2016) Stephen M. Vindigni et al.   Therapeutic Advances in Gastroenterology

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Is the world supply of omega-3 fatty acids adequate for optimal human nutrition?

(2015) Norman Salem et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine

(2015) Emanuela Sala et al.   GASTROENTEROLOGY

Polyunsaturated fatty acids and inflammation

(2015) Rachel Marion-Letellier et al.   IUBMB LIFE

Monocyte-derived Macrophages from Crohn's Disease Patients Are Impaired in the Ability to Control Intracellular Adherent-Invasive Escherichia coli and Exhibit Disordered Cytokine Secretion Profile

(2015) E. Vazeille et al.   Journal of Crohns & Colitis

Modulation of endothelial cell integrity and inflammatory activation by commercial lipid emulsions

(2015) Kevin A Harvey et al.   Lipids in Health and Disease

Dietary supplementation with omega-3 fatty acid attenuates 5-fluorouracil induced mucositis in mice

(2015) Simone de Vasconcelos Generoso et al.   Lipids in Health and Disease

Omega-3 fatty acids and inflammation: A perspective on the challenges of evaluating efficacy in clinical research

(2015) Ann C. Skulas-Ray   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The resolution of inflammation: Principles and challenges

(2015) Sarah E. Headland et al.   SEMINARS IN IMMUNOLOGY

The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology

(2015) Mauro Perretti   SEMINARS IN IMMUNOLOGY

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Association between high dietary intake of then−3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease

(2014) S. S. M. Chan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Comparing histological activity indexes in UC

(2014) Aude Bressenot et al.   GUT

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

(2014) Silvia D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

n–3 PUFAs Reduce T-Helper 17 Cell Differentiation by Decreasing Responsiveness to Interleukin-6 in Isolated Mouse Splenic CD4+ T Cells

(2014) M. Jeannie Allen et al.   JOURNAL OF NUTRITION

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

(2014) Puneet Kaur Randhawa et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The gut microbiota and inflammatory bowel disease

(2014) Katsuyoshi Matsuoka et al.   Seminars in Immunopathology

Is there a role for fish oil in inflammatory bowel disease?

(2014) Affifa Farrukh   World Journal of Clinical Cases

Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4)

(2013) Xinzhi Li et al.   FASEB JOURNAL

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Polyunsaturated Fatty Acids in Inflammatory Bowel Diseases

(2013) Rachel Marion-Letellier et al.   INFLAMMATORY BOWEL DISEASES

G protein-coupled receptor120 (GPR120) transcription in intestinal epithelial cells is significantly affected by bacteria belonging to the Bacteroides, Proteobacteria, and Firmicutes phyla1

(2013) M. Fredborg et al.   JOURNAL OF ANIMAL SCIENCE

Altered colonic mucosal availability of n-3 and n-6 polyunsaturated fatty acids in ulcerative colitis and the relationship to disease activity

(2013) Daniel S. Pearl et al.   Journal of Crohns & Colitis

Maresin 1, a Proresolving Lipid Mediator Derived from Omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis

(2013) R. Marcon et al.   JOURNAL OF IMMUNOLOGY

Nutritional protective mechanisms against gut inflammation

(2013) Monica Viladomiu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pathways mediating resolution of inflammation: when enough is too much

(2013) James N Fullerton et al.   JOURNAL OF PATHOLOGY

Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells

(2013) Kaia Mobraten et al.   Lipids in Health and Disease

Altered Colonic Mucosal Polyunsaturated Fatty Acid (PUFA) Derived Lipid Mediators in Ulcerative Colitis: New Insight into Relationship with Disease Activity and Pathophysiology

(2013) Mojgan Masoodi et al.   PLoS One

Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust

(2013) Tara M Nordgren et al.   RESPIRATORY RESEARCH

Targeting Neutrophil Apoptosis for Enhancing the Resolution of Inflammation

(2013) Driss El Kebir et al.   Cells

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

(2012) Philip C. Calder   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease

(2012) Anupama Tyagi et al.   BRITISH JOURNAL OF NUTRITION

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

Effect of an omega-3 lipid emulsion in reducing oxidative stress in a rat model of intestinal ischemia−reperfusion injury

(2012) Atsuhiro Arisue et al.   PEDIATRIC SURGERY INTERNATIONAL

Dietary n-3 Polyunsaturated Fatty Acids (PUFA) Decrease Obesity-Associated Th17 Cell-Mediated Inflammation during Colitis

(2012) Jennifer M. Monk et al.   PLoS One

Omega 3 fatty acids supplementation has an ameliorative effect in experimental ulcerative colitis despite increased colonic neutrophil infiltration

(2012) Ioannis Varnalidis et al.   REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS

Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease

(2011) Silvio Danese   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut

(2011) Stefan Koch et al.   Annual Review of Pathology-Mechanisms of Disease

Dietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated mice

(2011) Qian Jia et al.   BRITISH JOURNAL OF NUTRITION

Anti-inflammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endothelium

(2011) Ayman Ibrahim et al.   CLINICAL NUTRITION

Omega-3 Fatty Acid-Derived Mediators 17(R)-Hydroxy Docosahexaenoic Acid, Aspirin-Triggered Resolvin D1 and Resolvin D2 Prevent Experimental Colitis in Mice

(2011) A. F. Bento et al.   JOURNAL OF IMMUNOLOGY

Th17 Cell Accumulation Is Decreased during Chronic Experimental Colitis by (n-3) PUFA in Fat-1 Mice

(2011) Jennifer M. Monk et al.   JOURNAL OF NUTRITION

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Unravelling the effects of the environment and host genotype on the gut microbiome

(2011) Aymé Spor et al.   NATURE REVIEWS MICROBIOLOGY

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats

(2011) Tore Grimstad et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation

(2010) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis

(2010) H. L. Woodworth et al.   CANCER RESEARCH

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study

(2010) Sneha John et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

N-3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease

(2010) Kan Uchiyama et al.   INFLAMMATORY BOWEL DISEASES

Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): A systematic review and meta-analyses

(2010) Dan Turner et al.   INFLAMMATORY BOWEL DISEASES

Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids

(2010) Cosima Arnold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced platelet adhesion induces angiogenesis in intestinal inflammation and inflammatory bowel disease microvasculature

(2010) Sergio Rutella et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice

(2010) Jae Young Cho et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification

(2010) E. L. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteral diets enriched with medium-chain triglycerides and N-3 fatty acids prevent chemically induced experimental colitis in rats

(2010) Hiroshi Kono et al.   Translational Research

Inflammation in the Intestinal Tract: Pathogenesis and Treatment

(2009) Richard S. Blumberg   DIGESTIVE DISEASES

The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease

(2009) Franco Scaldaferri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium–induced colitis

(2009) Tsukasa Ishida et al.   INFLAMMATORY BOWEL DISEASES

The gastrointestinal microbiome: a malleable, third genome of mammals

(2009) Ian M. Carroll et al.   MAMMALIAN GENOME

Multiple Pathogenic Roles of Microvasculature in Inflammatory Bowel Disease: A Jack of All Trades

(2008) Livija Deban et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of short-term oral administration of dietary marine oils in patients with inflammatory bowel disease and joint pain: A pilot study comparing seal oil and cod liver oil

(2008) Linn A. Brunborg et al.   CLINICAL NUTRITION

Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts

(2008) Hisayuki Matsunaga et al.   INFLAMMATORY BOWEL DISEASES

Omega-3 Free Fatty Acids for the Maintenance of Remission in Crohn Disease

(2008) Brian G. Feagan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface

(2008) Holger K. Eltzschig et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The opposing effects of n−3 and n−6 fatty acids

(2007) Gerd Schmitz et al.   PROGRESS IN LIPID RESEARCH