NADPH Oxidases and Mitochondria in Vascular Senescence

The role of NADPH oxidases in diabetic cardiomyopathy

(2018) Synne S. Hansen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification of protein phosphatase involvement in the AT 2 receptor-induced activation of endothelial nitric oxide synthase

(2018) A. Augusto Peluso et al.   CLINICAL SCIENCE

Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons

(2018) Eunju Nam et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Vacuolar ATPase in phago(lyso)some biology

(2018) Sandra Kissing et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Metal binding properties of zinc fingers with a naturally altered metal binding site

(2018) Katarzyna Kluska et al.   Metallomics

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence

(2017) Marco Malavolta et al.   EXPERIMENTAL GERONTOLOGY

Microvascular NADPH oxidase in health and disease

(2017) Yao Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aging-associated metabolic disorder induces Nox2 activation and oxidative damage of endothelial function

(2017) Lampson M. Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells

(2017) G. Salazar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4 regulates the eNOS uncoupling process in aging endothelial cells

(2017) Hwa-Young Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells

(2017) Yuri Sakai et al.   FREE RADICAL RESEARCH

NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis

(2017) Andrey Lozhkin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation

(2017) Sandeep Kumar et al.   LABORATORY INVESTIGATION

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Alternative Splicing of NOX4 in the Failing Human Heart

(2017) Zoltán V. Varga et al.   Frontiers in Physiology

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

(2016) Elyse Di Marco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence

(2016) I-Ching Tsai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn 2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria

(2016) Yuliya V. Medvedeva et al.   JOURNAL OF NEUROSCIENCE

Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt–GLUT4, GSK3β and mTOR–S6K1

(2016) Yuntang Wu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

(2016) J. Wang et al.   JOURNAL OF VASCULAR SURGERY

Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells

(2016) Elena De Falco et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc

(2016) J. E. J. Hardyman et al.   Metallomics

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity

(2016) Yitong Zhao et al.   TRAFFIC

NOX4 downregulation leads to senescence of human vascular smooth muscle cells

(2016) Dorota Przybylska et al.   Oncotarget

NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

(2015) Aleksandr E. Vendrov et al.   ANTIOXIDANTS & REDOX SIGNALING

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory PhenotypeSignificance

(2015) Sarah E. Gardner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular RemodelingSignificance

(2015) Stephen P. Gray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo

(2015) Petra Sabine Eisele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

(2015) Heike Langbein et al.   EUROPEAN HEART JOURNAL

The NADPH oxidase Nox4 has anti-atherosclerotic functions

(2015) Christoph Schürmann et al.   EUROPEAN HEART JOURNAL

Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions

(2015) Siobhan M. Craige et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heterodimerization, Altered Subcellular Localization, and Function of Multiple Zinc Transporters in Viable Cells Using Bimolecular Fluorescence Complementation

(2015) Yarden Golan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases

(2015) Shiqin Xiong et al.   Cell Reports

Mitochondrial KATP channel involvement in angiotensin II-induced autophagy in vascular smooth muscle cells

(2014) Kang-Ying Yu et al.   BASIC RESEARCH IN CARDIOLOGY

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis

(2014) C. G. Sobey et al.   FREE RADICAL RESEARCH

PI3K/Akt/uncoupling protein 2 signaling pathway may be involved in cell senescence and apoptosis induced by angiotensin II in human vascular endothelial cells

(2014) Ping Li et al.   MOLECULAR BIOLOGY REPORTS

Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques

(2014) Shaoping Xu et al.   Redox Biology

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Is a Central Negative Regulator of Vascular Senescence

(2013) Shiqin Xiong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

T cells in atherosclerosis

(2013) K. Tse et al.   INTERNATIONAL IMMUNOLOGY

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

(2013) Hongmei Luo et al.   PLoS One

Mechanisms of Rapid Reactive Oxygen Species Generation in Response to Cytosolic Ca2+ or Zn2+ Loads in Cortical Neurons

(2013) Aaron Clausen et al.   PLoS One

A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells

(2013) Yogita Mistry et al.   Redox Biology

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4

(2012) Katherine J. Massey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature

(2012) Aurelie Nguyen Dinh Cat et al.   ANTIOXIDANTS & REDOX SIGNALING

Noxa1 as a moderate activator of Nox2-based NADPH oxidase

(2012) Masahito Kawano et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Cellular senescence: a double-edged sword in the fight against cancer

(2012) Naoko Ohtani et al.   EXPERIMENTAL DERMATOLOGY

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

(2012) Ryo Kodama et al.   GENES TO CELLS

Constitutive NADPH Oxidase 4 Activity Resides in the Composition of the B-loop and the Penultimate C Terminus

(2012) Katharina von Löhneysen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells

(2012) Petra S. Eisele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Angiotensin II Requires Zinc and Downregulation of the Zinc Transporters ZnT3 and ZnT10 to Induce Senescence of Vascular Smooth Muscle Cells

(2012) Nikolay Patrushev et al.   PLoS One

Role for Nox1 NADPH oxidase in atherosclerosis

(2011) Andrea L. Sheehan et al.   ATHEROSCLEROSIS

Dynamic Changes in Regulatory T Cells Are Linked to Levels of Diet-Induced Hypercholesterolemia

(2011) Elena Maganto-García et al.   CIRCULATION

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Correlation of Different NADPH Oxidase Homologues with Late Endothelial Progenitor Cell Senescence Induced by Angiotensin II: Effect of Telmisartan

(2011) Hong Li et al.   INTERNAL MEDICINE

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ageing theories unified

(2011) Daniel P. Kelly   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

A Local Proinflammatory Signalling Loop Facilitates Adverse Age-Associated Arterial Remodeling

(2011) Mingyi Wang et al.   PLoS One

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

(2010) Nicolai Treiber et al.   AGING CELL

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

(2010) Anna E. Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats

(2010) S Bosnyak et al.   BRITISH JOURNAL OF PHARMACOLOGY

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells

(2010) David Álvarez-Guardia et al.   CARDIOVASCULAR RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation

(2010) Davide Gianni et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

(2010) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Regulation of NOXO1 Activity through Reversible Interactions with p22phox and NOXA1

(2010) Sujit Dutta et al.   PLoS One

Age-Related Changes in Redox Signaling and VSMC Function

(2009) Muyao Li et al.   ANTIOXIDANTS & REDOX SIGNALING

The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells

(2009) Barbara Lener et al.   BIOCHEMICAL JOURNAL

Inhibition of renin–angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation

(2009) Daiju Fukuda et al.   BIOMEDICINE & PHARMACOTHERAPY

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drive Catalase Down-regulation and Vascular Hypertrophy

(2009) Shiqin Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of the Ang II type 1 receptor promotes longevity in mice

(2009) Ariela Benigni et al.   JOURNAL OF CLINICAL INVESTIGATION

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species

(2008) Hideki Sumimoto   FEBS Journal

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH