Alternative Splicing of NOX4 in the Failing Human Heart

Mitochondria and oxidative stress in heart aging

(2016) Beatriz Martín-Fernández et al.   AGE

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling

(2016) Shouji Matsushima et al.   JOURNAL OF CLINICAL INVESTIGATION

Aberrant splicing and drug resistance in AML

(2016) Rosalia de Necochea-Campion et al.   Journal of Hematology & Oncology

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

Nox/Duox Family of NADPH Oxidases: Lessons from Knockout Mouse Models

(2016) Gábor Sirokmány et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alternative splicing as a biomarker and potential target for drug discovery

(2015) Kai-qin Le et al.   ACTA PHARMACOLOGICA SINICA

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

(2015) Christine Hirschhäuser et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NF B Signaling Pathways

(2015) Q. D. Zhao et al.   CIRCULATION

Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study

(2015) Júlia Baán et al.   Journal of Translational Medicine

Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart

(2015) Adam Nabeebaccus et al.   LANCET

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization

(2014) Marina M. López-Olañeta et al.   CARDIOVASCULAR RESEARCH

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

(2014) Henrike Maatz et al.   JOURNAL OF CLINICAL INVESTIGATION

A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular Cells

(2013) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

(2013) Zoltán V. Varga et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Alternative Heart: Impact of Alternative Splicing in Heart Disease

(2013) Enrique Lara-Pezzi et al.   Journal of Cardiovascular Translational Research

Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

(2012) Dao-Fu Dai et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells

(2012) Daniel Siuda et al.   BASIC RESEARCH IN CARDIOLOGY

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

(2012) Wei Guo et al.   NATURE MEDICINE

NOX2β: A Novel Splice Variant of NOX2 That Regulates NADPH Oxidase Activity in Macrophages

(2012) Craig B. Harrison et al.   PLoS One

Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes

(2011) Rita M. Maalouf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Role of RBM25/LUC7L3 in Abnormal Cardiac Sodium Channel Splicing Regulation in Human Heart Failure

(2011) Ge Gao et al.   CIRCULATION

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse

(2010) Che-Chung Yeh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Epidemiology and risk profile of heart failure

(2010) Anh L. Bui et al.   Nature Reviews Cardiology

Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease

(2010) Douglas B. Kuhns et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

(2010) Beth A. Rose et al.   PHYSIOLOGICAL REVIEWS

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

(2009) Thomas L. Leto et al.   ANTIOXIDANTS & REDOX SIGNALING

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS