Axis of ageing: telomeres, p53 and mitochondria

TAp63: The fountain of youth

(2016) Xiaohua Su et al.   Aging-US

p53, ROS and senescence in the control of aging

(2016) Arnaud Vigneron et al.   Aging-US

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice

(2011) Holly M. Brown-Borg et al.   AGE

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

(2011) Bruno Bernardes de Jesus et al.   AGING CELL

An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle

(2011) Jonathan P. Little et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway

(2011) Jin Young Sung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ataxia telangiectasia mutated influences cytochrome c oxidase activity

(2011) Akshar Y. Patel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration

(2011) Da-Qing Yang et al.   DRUG DISCOVERY TODAY

Hematopoietic stem cell development, aging and functional failure

(2011) Jichun Chen   INTERNATIONAL JOURNAL OF HEMATOLOGY

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

(2011) Marianna Sadagurski et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypes in mTERT+/- and mTERT-/- Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase

(2011) M. A. Strong et al.   MOLECULAR AND CELLULAR BIOLOGY

How cells sense energy

(2011) D. Grahame Hardie   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

(2011) Nilesh K. Sharma et al.   NUCLEIC ACIDS RESEARCH

Short Telomeres Compromise β-Cell Signaling and Survival

(2011) Nini Guo et al.   PLoS One

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Genetic variation in insulin/IGF-1 signaling pathways and longevity

(2010) Elad Ziv et al.   AGEING RESEARCH REVIEWS

A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction

(2010) Olga A. Kovalenko et al.   AGING CELL

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

(2010) Dao-Fu Dai et al.   AGING CELL

Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome

(2010) Federico V. Pallardó et al.   BIOGERONTOLOGY

The AMPK-FoxO3A axis as a target for cancer treatment

(2010) Fulvio Chiacchiera et al.   CELL CYCLE

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

The Aging Stress Response

(2010) Marcia C. Haigis et al.   MOLECULAR CELL

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TOR and ageing: a complex pathway for a complex process

(2010) M. A. McCormick et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

(2010) Zhaohui Feng et al.   TRENDS IN CELL BIOLOGY

p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress

(2009) Natascia Ventura et al.   AGING CELL

Syndromes of Telomere Shortening

(2009) Mary Armanios   Annual Review of Genomics and Human Genetics

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

(2009) Judith Haendeler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

(2009) Ji-hye Paik et al.   Cell Stem Cell

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

(2009) Sofia L. Vidal-Cardenas et al.   NUCLEIC ACIDS RESEARCH

A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres

(2009) Ignacio Flores et al.   PLoS One

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

(2008) Antonia Tomás-Loba et al.   CELL

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Actions of human telomerase beyond telomeres

(2008) Yusheng Cong et al.   CELL RESEARCH

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT

Expanding the clinical phenotype of autosomal dominant dyskeratosis congenita caused by TERT mutations

(2008) L. Basel-Vanagaite et al.   HAEMATOLOGICA

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

(2008) Meltem Muftuoglu et al.   HUMAN GENETICS

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE

How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?

(2008) George Hinkal et al.   MECHANISMS OF AGEING AND DEVELOPMENT

TERT promotes cellular and organismal survival independently of telomerase activity

(2008) J Lee et al.   ONCOGENE

Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle

(2008) Ayesha Saleem et al.   PHYSIOLOGICAL GENOMICS

Telomeres and Aging

(2008) Geraldine Aubert et al.   PHYSIOLOGICAL REVIEWS

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

(2008) Jinkuk Choi et al.   PLoS Genetics

Dyskeratosis congenita: The diverse clinical presentation of mutations in the telomerase complex

(2007) T.J. Vulliamy et al.   BIOCHIMIE