NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells

NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis

(2017) Andrey Lozhkin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway

(2017) Arpita Chatterjee et al.   RADIATION RESEARCH

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

(2017) Katharine M Irvine et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of NOX1 on fibroblastic changes of endothelial cells in radiation-induced pulmonary fibrosis

(2016) SEO-HYUN CHOI et al.   Molecular Medicine Reports

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

(2016) Aleksandra Borodkina et al.   Aging-US

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Downregulation of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 stimulates transforming growth factor-β1 production and promotes actin rearrangement

(2015) Yuri Sakai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

(2015) Ahmed Bettaieb et al.   GASTROENTEROLOGY

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation

(2015) Rabii Ameziane-El-Hassani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer

(2015) Xiyu Liu et al.   TUMOR BIOLOGY

Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence

(2014) R. R. Nair et al.   JOURNAL OF CELL SCIENCE

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Current ideas to reduce or salvage radiation damage to salivary glands

(2014) A Vissink et al.   ORAL DISEASES

In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells

(2014) Birgit Berkenkamp et al.   PLoS One

Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation

(2014) P. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Signaling as a Therapeutic Target to Inhibit Myofibroblast Activation in Degenerative Fibrotic Disease

(2014) Natalie Sampson et al.   Biomed Research International

NADPH Oxidases in Vascular Pathology

(2013) Anna Konior et al.   ANTIOXIDANTS & REDOX SIGNALING

Senescence at a glance

(2013) J. S. Pawlikowski et al.   JOURNAL OF CELL SCIENCE

Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells

(2012) Clintoria R. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of innate immunity by NADPH oxidase

(2012) Brahm H. Segal et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

(2012) Ryo Kodama et al.   GENES TO CELLS

X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells

(2012) Ronald Allan M. Panganiban et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Oxidative Stress, Nox Isoforms and Complications of Diabetes—Potential Targets for Novel Therapies

(2012) Mona Sedeek et al.   Journal of Cardiovascular Translational Research

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: Identification of functional antioxidant response elements on the Nox4 promoter

(2011) Srikanth Pendyala et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

NADPH oxidase 4 is an oncoprotein localized to mitochondria

(2010) Kelly A. Graham et al.   CANCER BIOLOGY & THERAPY

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells

(2009) Adrian Manea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells

(2009) Yvonne D.C. Schilder et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase

(2009) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SASPense and DDRama in cancer and ageing

(2009) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells

(2008) J. Racquel Collins-Underwood et al.   FREE RADICAL BIOLOGY AND MEDICINE