Rho signaling research: history, current status and future directions

Critical role of ROCK2 activity in facilitating mucosal CD4 + T cell activation in inflammatory bowel disease

(2018) Wenjing Yang et al.   JOURNAL OF AUTOIMMUNITY

Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

(2017) Alexandra Zanin-Zhorov et al.   JOURNAL OF IMMUNOLOGY

Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine

(2017) Andrew M. Swanson et al.   Nature Communications

Discovery of long-range inhibitory signaling to ensure single axon formation

(2017) Tetsuya Takano et al.   Nature Communications

Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE

(2016) Cristina Rozo et al.   ANNALS OF THE RHEUMATIC DISEASES

Novel Insights into the Roles of Rho Kinase in Cancer

(2016) Lei Wei et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

(2016) R. Flynn et al.   BLOOD

Open questions: what about the ‘other’ Rho GTPases?

(2016) Anne J. Ridley   BMC BIOLOGY

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

RhoA orchestrates glycolysis for T H 2 cell differentiation and allergic airway inflammation

(2016) Jun-Qi Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety

(2016) Yuichi Deguchi et al.   Cell Reports

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

(2016) Sandra Kümper et al.   eLife

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

(2015) Masatoshi Ohgushi et al.   Cell Stem Cell

A self-organized biomechanical network drives shape changes during tissue morphogenesis

(2015) Akankshi Munjal et al.   NATURE

The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease

(2015) Svenja Hartmann et al.   Frontiers in Pharmacology

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

(2014) A. C. Martin et al.   DEVELOPMENT

Mouse Macrophages Completely Lacking Rho Subfamily GTPases (RhoA, RhoB, and RhoC) Have Severe Lamellipodial Retraction Defects, but Robust Chemotactic Navigation and Altered Motility

(2014) Volker Königs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

(2014) Miwako Kakiuchi et al.   NATURE GENETICS

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

(2014) Alexandra Zanin-Zhorov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon growth inhibition by RhoA/ROCK in the central nervous system

(2014) Yuki Fujita et al.   Frontiers in Neuroscience

Crucial Role of ROCK2 in Vascular Smooth Muscle Cells for Hypoxia-Induced Pulmonary Hypertension in Mice

(2013) Toru Shimizu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Physiological roles of Rho and Rho effectors in mammals

(2013) Dean Thumkeo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

RhoA, RhoB and RhoC have different roles in cancer cell migration

(2013) A.J. RIDLEY   JOURNAL OF MICROSCOPY

Rho-Kinase Accelerates Synaptic Vesicle Endocytosis by Linking Cyclic GMP-Dependent Protein Kinase Activity to Phosphatidylinositol-4,5-Bisphosphate Synthesis

(2013) Z. Taoufiq et al.   JOURNAL OF NEUROSCIENCE

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

Transforming mutations of RAC guanosine triphosphatases in human cancers

(2013) M. Kawazu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective ROCK2 inhibition in focal cerebral ischemia

(2013) Jeong Hyun Lee et al.   Annals of Clinical and Translational Neurology

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

(2012) Tamako Nishimura et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Rho GTPase function in development: How in vivo models change our view

(2012) Esben Pedersen et al.   EXPERIMENTAL CELL RESEARCH

FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2

(2012) Ryuji Okamoto et al.   FASEB JOURNAL

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

(2012) Ryota Shinohara et al.   NATURE NEUROSCIENCE

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Role of Rho kinase isoforms in murine allergic airway responses

(2011) M. Zhu et al.   EUROPEAN RESPIRATORY JOURNAL

RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts

(2011) Jaime Melendez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Deficiency of mDia, an Actin Nucleator, Disrupts Integrity of Neuroepithelium and Causes Periventricular Dysplasia

(2011) Dean Thumkeo et al.   PLoS One

Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells

(2010) Masatoshi Ohgushi et al.   Cell Stem Cell

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration

(2010) Sarah J. Heasman et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

(2009) T. Y. Kim et al.   CANCER AND METASTASIS REVIEWS

Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord

(2009) P. Duffy et al.   JOURNAL OF NEUROSCIENCE

The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation

(2008) Dedmer Schaafsma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling

(2008) T. Nishimura et al.   DEVELOPMENT

Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors

(2007) Masaomi Koyanagi et al.   JOURNAL OF NEUROSCIENCE RESEARCH